| Literature DB >> 23601689 |
Gerlinde Obermoser1, Scott Presnell, Kelly Domico, Hui Xu, Yuanyuan Wang, Esperanza Anguiano, Luann Thompson-Snipes, Rajaram Ranganathan, Brad Zeitner, Anna Bjork, David Anderson, Cate Speake, Emily Ruchaud, Jason Skinner, Laia Alsina, Mamta Sharma, Helene Dutartre, Alma Cepika, Elisabeth Israelsson, Phuong Nguyen, Quynh-Anh Nguyen, A Carson Harrod, Sandra M Zurawski, Virginia Pascual, Hideki Ueno, Gerald T Nepom, Charlie Quinn, Derek Blankenship, Karolina Palucka, Jacques Banchereau, Damien Chaussabel.
Abstract
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23601689 PMCID： PMC3681204 DOI： 10.1016/j.immuni.2012.12.008
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745