Literature DB >> 23587951

BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2).

Nicholas G Brown1, Dar-Chone Chow, Timothy Palzkill.   

Abstract

β-Lactamase inhibitory protein II (BLIP-II) is a potent inhibitor of class A β-lactamases. KPC-2 is a class A β-lactamase that is capable of hydrolyzing carbapenems and has become a widespread source of resistance to these drugs for Gram-negative bacteria. Determination of association and dissociation rate constants for binding between BLIP-II and KPC-2 reveals a very tight interaction with a calculated (koff/kon) equilibrium dissociation constant of 76 fM (76 × 10(-15) M).

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Year:  2013        PMID： 23587951      PMCID： PMC3697393          DOI： 10.1128/AAC.00215-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

Review 1.  The emerging NDM carbapenemases.

Authors:  Patrice Nordmann; Laurent Poirel; Timothy R Walsh; David M Livermore
Journal:  Trends Microbiol       Date:  2011-11-09       Impact factor: 17.079

Review 2.  Fourteen years in resistance.

Authors:  David M Livermore
Journal:  Int J Antimicrob Agents       Date:  2012-03-03       Impact factor: 5.283

3.  Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases.

Authors:  Nicholas G Brown; Dar-Chone Chow; Banumathi Sankaran; Peter Zwart; B V Venkataram Prasad; Timothy Palzkill
Journal:  J Biol Chem       Date:  2011-07-20       Impact factor: 5.157

Review 4.  Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria.

Authors:  Karen Bush; Jed F Fisher
Journal:  Annu Rev Microbiol       Date:  2011       Impact factor: 15.500

Review 5.  Carbapenems: past, present, and future.

Authors:  Krisztina M Papp-Wallace; Andrea Endimiani; Magdalena A Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

6.  Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein.

Authors:  Melinda S Hanes; Kevin M Jude; James M Berger; Robert A Bonomo; Tracy M Handel
Journal:  Biochemistry       Date:  2009-10-06       Impact factor: 3.162

7.  Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258.

Authors:  Brandon Kitchel; J Kamile Rasheed; Jean B Patel; Arjun Srinivasan; Shiri Navon-Venezia; Yehuda Carmeli; Alma Brolund; Christian G Giske
Journal:  Antimicrob Agents Chemother       Date:  2009-06-08       Impact factor: 5.191

Review 8.  Fundamental aspects of protein-protein association kinetics.

Authors:  G Schreiber; G Haran; H-X Zhou
Journal:  Chem Rev       Date:  2009-03-11       Impact factor: 60.622

9.  Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.

Authors:  Gaelle Cuzon; Thierry Naas; HaVy Truong; Maria Virginia Villegas; Karin T Wisell; Yehuda Carmeli; Ana C Gales; Shiri Navon Venezia; John P Quinn; Patrice Nordmann
Journal:  Emerg Infect Dis       Date:  2010-09       Impact factor: 6.883

10.  Molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals Intergenus KPC carbapenemase transmission through a promiscuous plasmid.

Authors:  Amy J Mathers; Heather L Cox; Brandon Kitchel; Hugo Bonatti; Ann Karen C Brassinga; Joanne Carroll; W Michael Scheld; Kevin C Hazen; Costi D Sifri
Journal:  MBio       Date:  2011-11-01       Impact factor: 7.867
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  5 in total

1.  Identification of the β-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A β-lactamases.

Authors:  Nicholas G Brown; Dar-Chone Chow; Kevin E Ruprecht; Timothy Palzkill
Journal:  J Biol Chem       Date:  2013-04-27       Impact factor: 5.157

2.  Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).

Authors:  Orville A Pemberton; Xiujun Zhang; Yu Chen
Journal:  J Med Chem       Date:  2017-04-17       Impact factor: 7.446

3.  Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

Authors:  Shrenik C Mehta; Kacie Rice; Timothy Palzkill
Journal:  PLoS Pathog       Date:  2015-06-01       Impact factor: 6.823

Review 4.  Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.

Authors:  Focco van den Akker; Robert A Bonomo
Journal:  Front Microbiol       Date:  2018-04-05       Impact factor: 5.640

Review 5.  Tackling the Antibiotic Resistance Caused by Class A β-Lactamases through the Use of β-Lactamase Inhibitory Protein.

Authors:  Warawan Eiamphungporn; Nalini Schaduangrat; Aijaz Ahmad Malik; Chanin Nantasenamat
Journal:  Int J Mol Sci       Date:  2018-07-30       Impact factor: 5.923
  5 in total

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