Literature DB >> 28388065

Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).

Orville A Pemberton1, Xiujun Zhang1, Yu Chen1.   

Abstract

Carbapenem-resistant Enterobacteriaceae are resistant to most β-lactam antibiotics due to the production of the Klebsiella pneumoniae carbapenemase (KPC-2) class A β-lactamase. Here, we present the first product complex crystal structures of KPC-2 with β-lactam antibiotics containing hydrolyzed cefotaxime and faropenem. They provide experimental insights into substrate recognition by KPC-2 and its unique cephalosporinase/carbapenemase activity. These structures also represent the first product complexes for a wild-type serine β-lactamase, elucidating the product release mechanism of these enzymes in general.

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Year:  2017        PMID： 28388065      PMCID： PMC5506774          DOI： 10.1021/acs.jmedchem.7b00158

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  36 in total

1.  Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.

Authors:  Krisztina M Papp-Wallace; Marisa L Winkler; Magdalena A Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2015-02-09       Impact factor: 5.191

Review 2.  Extended-spectrum-beta-lactamase, AmpC, and Carbapenemase issues.

Authors:  Kenneth S Thomson
Journal:  J Clin Microbiol       Date:  2010-02-24       Impact factor: 5.948

Review 3.  Updated functional classification of beta-lactamases.

Authors:  Karen Bush; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2009-12-07       Impact factor: 5.191

Review 4.  Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention.

Authors:  Neil Gupta; Brandi M Limbago; Jean B Patel; Alexander J Kallen
Journal:  Clin Infect Dis       Date:  2011-07-01       Impact factor: 9.079

5.  Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.

Authors:  Samy O Meroueh; Jed F Fisher; H Bernhard Schlegel; Shahriar Mobashery
Journal:  J Am Chem Soc       Date:  2005-11-09       Impact factor: 15.419

6.  Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Authors:  Krisztina M Papp-Wallace; Christopher R Bethel; Anne M Distler; Courtney Kasuboski; Magdalena Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

7.  Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin.

Authors:  Tatsuro Shimamura; Akiko Ibuka; Shinya Fushinobu; Takayoshi Wakagi; Masaji Ishiguro; Yoshikazu Ishii; Hiroshi Matsuzawa
Journal:  J Biol Chem       Date:  2002-09-08       Impact factor: 5.157

8.  Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.

Authors:  Michiyosi Nukaga; Christopher R Bethel; Jodi M Thomson; Andrea M Hujer; Anne Distler; Vernon E Anderson; James R Knox; Robert A Bonomo
Journal:  J Am Chem Soc       Date:  2008-08-30       Impact factor: 15.419

Review 9.  Class A carbapenemases.

Authors:  Jan Walther-Rasmussen; Niels Høiby
Journal:  J Antimicrob Chemother       Date:  2007-06-26       Impact factor: 5.790

10.  Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.

Authors:  Derek A Nichols; Jacqueline C Hargis; Ruslan Sanishvili; Priyadarshini Jaishankar; Kyle Defrees; Emmanuel W Smith; Kenneth K Wang; Fabio Prati; Adam R Renslo; H Lee Woodcock; Yu Chen
Journal:  J Am Chem Soc       Date:  2015-06-22       Impact factor: 15.419
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  20 in total

1.  Influence of substrates and inhibitors on the structure of Klebsiella pneumoniae carbapenemase-2.

Authors:  Ben A Shurina; Richard C Page
Journal:  Exp Biol Med (Maywood)       Date:  2019-06-04

2.  Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.

Authors:  Orville A Pemberton; Xiujun Zhang; Derek A Nichols; Kyle DeFrees; Priyadarshini Jaishankar; Richard Bonnet; Jessie Adams; Lindsey N Shaw; Adam R Renslo; Yu Chen
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191

3.  Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.

Authors:  Orville A Pemberton; Priyadarshini Jaishankar; Afroza Akhtar; Jessie L Adams; Lindsey N Shaw; Adam R Renslo; Yu Chen
Journal:  J Med Chem       Date:  2019-09-13       Impact factor: 7.446

4.  The Role of Hydrophobic Nodes in the Dynamics of Class A β-Lactamases.

Authors:  Edgar Olehnovics; Junqi Yin; Adrià Pérez; Gianni De Fabritiis; Robert A Bonomo; Debsindhu Bhowmik; Shozeb Haider
Journal:  Front Microbiol       Date:  2021-09-21       Impact factor: 5.640

5.  Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase.

Authors:  M Trent Kemp; Derek A Nichols; Xiujun Zhang; Kyle Defrees; Insung Na; Adam R Renslo; Yu Chen
Journal:  FEBS Lett       Date:  2021-11-07       Impact factor: 4.124

6.  Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition.

Authors:  Philip Hinchliffe; Catherine L Tooke; Christopher R Bethel; Benlian Wang; Christopher Arthur; Kate J Heesom; Stuart Shapiro; Daniela M Schlatzer; Krisztina M Papp-Wallace; Robert A Bonomo; James Spencer
Journal:  mBio       Date:  2022-05-25       Impact factor: 7.786

7.  Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.

Authors:  T A Alsenani; S L Viviani; V Kumar; M A Taracila; C R Bethel; M D Barnes; K M Papp-Wallace; R K Shields; M H Nguyen; C J Clancy; R A Bonomo; F van den Akker
Journal:  Antimicrob Agents Chemother       Date:  2022-03-28       Impact factor: 5.938

8.  Structural Basis and Binding Kinetics of Vaborbactam in Class A β-Lactamase Inhibition.

Authors:  Orville A Pemberton; Ruslan Tsivkovski; Maxim Totrov; Olga Lomovskaya; Yu Chen
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

9.  Local Interactions with the Glu166 Base and the Conformation of an Active Site Loop Play Key Roles in Carbapenem Hydrolysis by the KPC-2 β-lactamase.

Authors:  Ian M Furey; Shrenik C Mehta; Banumathi Sankaran; Liya Hu; B V Venkataram Prasad; Timothy Palzkill
Journal:  J Biol Chem       Date:  2021-05-19       Impact factor: 5.157

10.  Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition.

Authors:  Catherine L Tooke; Philip Hinchliffe; Alen Krajnc; Adrian J Mulholland; Jürgen Brem; Christopher J Schofield; James Spencer
Journal:  RSC Med Chem       Date:  2020-01-10
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