OBJECTIVE: To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. METHODS: The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment. RESULTS: Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05). CONCLUSIONS: It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.
OBJECTIVE: To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. METHODS: The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment. RESULTS: Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05). CONCLUSIONS: It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.
Authors: Roberta R Ruela de Sousa; Karla Cristiana Souza Queiroz; Ana Carolina Santos Souza; Sonia A Gurgueira; Amanda Cavallari Augusto; Marcio André Miranda; Maikel P Peppelenbosch; Carmen Veríssima Ferreira; Hiroshi Aoyama Journal: J Enzyme Inhib Med Chem Date: 2007-08 Impact factor: 5.051
Authors: Jun Ma; Xiao-Dong Luo; Petr Protiva; Hui Yang; Cuiying Ma; Margaret J Basile; I Bernard Weinstein; Edward J Kennelly Journal: J Nat Prod Date: 2003-07 Impact factor: 4.050
Authors: Abdelrahman M Abd El-Gawad; Diea G Abo El-Hassan; Ahmed M Aboul-Enein; Sherein S Abdelgayed; Salwa A Aly; Gamal Esmat; Amr A Mostafa; Mohamed H Bakr; Rida A Ali; Mahmoud A Ayoub Journal: Vet World Date: 2021-03-20