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Literature DB >> 6667118

A new approach to practical acute toxicity testing.

Abstract

A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50. This method has no limitations and applies to drugs, agricultural and industrial chemicals. It can be used for every route of administration.

Entities: Disease

Mesh：

Year: 1983 PMID： 6667118 DOI： 10.1007/bf01234480

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

3 in total

1. Significance of the LD50-test for the toxicological evaluation of chemical substances.

Authors: G Zbinden; M Flury-Roversi
Journal: Arch Toxicol Date: 1981-04 Impact factor: 5.153

2. Intercomparison study on the determination of single administration toxicity in rats.

Authors: W J Hunter; W Lingk; P Recht
Journal: J Assoc Off Anal Chem Date: 1979-07

3. Rapid and accurate determination of the median lethal dose (LD50) and its error with a small computer.

Authors: A P Rosiello; J M Essignmann; G N Wogan
Journal: J Toxicol Environ Health Date: 1977-12

3 in total

334 in total

Review 1. A national validation study of the acute-toxic-class method--an alternative to the LD50 test.

Authors: E Schlede; U Mischke; R Roll; D Kayser
Journal: Arch Toxicol Date: 1992 Impact factor: 5.153

2. Evaluation of analgesic and anti-inflammatory effects of ethanol extract of Ficus iteophylla leaves in rodents.

Authors: I A Abdulmalik; M I Sule; A M Musa; A H Yaro; M I Abdullahi; M F Abdulkadir; H Yusuf
Journal: Afr J Tradit Complement Altern Med Date: 2011-06-01

3. Phytochemical, analgesic and anti-inflammatory effects of the ethylacetate extract of the leaves of Pseudocedrella kotschyii.

Authors: Y M Musa; A K Haruna; M Ilyas; A H Yaro; A A Ahmadu; H Usman
Journal: Afr J Tradit Complement Altern Med Date: 2007-10-27

4. Analgesic and antipyretic effects of Sansevieria trifasciata leaves.

Authors: Jeba Sunilson J Anbu; P Jayaraj; R Varatharajan; John Thomas; James Jisha; M Muthappan
Journal: Afr J Tradit Complement Altern Med Date: 2009-07-03

5. Medicinal Plants Used in Wound Care: A Study of Prosopis africana (Fabaceae) Stem Bark.

Authors: A C Ezike; P A Akah; C O Okoli; S Udegbunam; N Okwume; C Okeke; O Iloani
Journal: Indian J Pharm Sci Date: 2010-05 Impact factor: 0.975

6. Behavioural effects of the methanolic root bark extract of Securinega virosa in rodents.

Authors: M G Magaji; J A Anuka; I Abdu-Aguye; A H Yaro; I M Hussaini
Journal: Afr J Tradit Complement Altern Med Date: 2008-01-22

7. Anti-nociceptive and anti-inflammatory activities of aqueous leaves extract of Ocimum gratissimum (Labiate) in rodents.

Authors: Y Tanko; G M Magaji; M Yerima; R A Magaji; A Mohammed
Journal: Afr J Tradit Complement Altern Med Date: 2008-01-22

Review 8. Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): a review.

Authors: Prasad G Jamkhande; Sonal R Barde; Shailesh L Patwekar; Priti S Tidke
Journal: Asian Pac J Trop Biomed Date: 2013-12

9. In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice.

Authors: Awodayo O Adepiti; Anthony A Elujoba; Oluseye O Bolaji
Journal: Parasitol Res Date: 2013-11-22 Impact factor: 2.289

10. Treatment of Brucellosis in Guinea Pigs via a Combination of Engineered Novel pH-Responsive Curcumin Niosome Hydrogel and Doxycycline-Loaded Chitosan-Sodium Alginate Nanoparticles: an In Vitro and In Vivo Study.

Authors: Fatma I Abo El-Ela; Khaled H Hussein; Hossny A El-Banna; Amr Gamal; Sherin Rouby; Ahmed M S Menshawy; El-Shimaa El-Nahass; Shehata Anwar; Mohamed M A Zeinhom; Heba F Salem; Marawa Ahmed Yahia Al-Sayed; Hala A El-Newery; Khaled A M Shokier; Khalid A El-Nesr; H I Hosein
Journal: AAPS PharmSciTech Date: 2020-11-18 Impact factor: 3.246