Literature DB >> 23567558

The FBW7-KLF2 axis regulates endothelial functions.

Yongchao Zhao1, Yi Sun.   

Abstract

FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.

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Year:  2013        PMID： 23567558      PMCID： PMC3674388          DOI： 10.1038/cr.2013.50

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

Authors:  Myoung Ok Kim; Sung-Hyun Kim; Yong-Yeon Cho; Janos Nadas; Chul-Ho Jeong; Ke Yao; Dong Joon Kim; Dong-Hoon Yu; Young-Sam Keum; Kun-Yeong Lee; Zunnan Huang; Ann M Bode; Zigang Dong
Journal:  Nat Struct Mol Biol       Date:  2012-02-05       Impact factor: 15.369

Review 2.  "Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.

Authors:  Lalitha Nayak; Zhiyong Lin; Mukesh K Jain
Journal:  Antioxid Redox Signal       Date:  2011-04-15       Impact factor: 8.401

3.  The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.

Authors:  Ning Liu; Hui Li; Shuangxi Li; Mingyue Shen; Ning Xiao; Yunfei Chen; Yan Wang; Weichao Wang; Rui Wang; Qian Wang; Jianhua Sun; Ping Wang
Journal:  J Biol Chem       Date:  2010-04-13       Impact factor: 5.157

4.  SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.

Authors:  Mingjia Tan; Yongchao Zhao; Sun-Jung Kim; Margaret Liu; Lijun Jia; Thomas L Saunders; Yuan Zhu; Yi Sun
Journal:  Dev Cell       Date:  2011-11-23       Impact factor: 12.270

Review 5.  Mammalian Krüppel-like factors in health and diseases.

Authors:  Beth B McConnell; Vincent W Yang
Journal:  Physiol Rev       Date:  2010-10       Impact factor: 37.312

Review 6.  Tumor suppressor functions of FBW7 in cancer development and progression.

Authors:  Zhiwei Wang; Hiroyuki Inuzuka; Jiateng Zhong; Lixin Wan; Hidefumi Fukushima; Fazlul H Sarkar; Wenyi Wei
Journal:  FEBS Lett       Date:  2012-03-21       Impact factor: 4.124

7.  Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

Authors:  Ryosuke Tsunematsu; Keiko Nakayama; Yuichi Oike; Masaaki Nishiyama; Noriko Ishida; Shigetsugu Hatakeyama; Yasumasa Bessho; Ryoichiro Kageyama; Toshio Suda; Keiichi I Nakayama
Journal:  J Biol Chem       Date:  2003-12-12       Impact factor: 5.157

Review 8.  FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.

Authors:  Markus Welcker; Bruce E Clurman
Journal:  Nat Rev Cancer       Date:  2008-02       Impact factor: 60.716

9.  Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.

Authors:  Michael T Tetzlaff; Wei Yu; Mamie Li; Pumin Zhang; Milton Finegold; Kathleen Mahon; J Wade Harper; Robert J Schwartz; Stephen J Elledge
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-06       Impact factor: 11.205

10.  FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation.

Authors:  Rui Wang; Yan Wang; Ning Liu; Chunguang Ren; Cong Jiang; Kai Zhang; Su Yu; Yunfei Chen; Hui Tang; Qi Deng; Cong Fu; Yingcong Wang; Rong Li; Mingyao Liu; Weijun Pan; Ping Wang
Journal:  Cell Res       Date:  2013-03-19       Impact factor: 25.617
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  3 in total

1.  Potential molecular mechanism of ACE gene at different time points in STEMI patients based on genome-wide microarray dataset.

Authors:  Yao-Zong Guan; Rui-Xing Yin; Peng-Fei Zheng; Guo-Xiong Deng; Chun-Xiao Liu; Bi-Liu Wei
Journal:  Lipids Health Dis       Date:  2019-10-23       Impact factor: 3.876

2.  An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.

Authors:  Helen A Brown; Charles A C Williams; Houjiang Zhou; Diana Rios-Szwed; Rosalia Fernandez-Alonso; Saria Mansoor; Liam McMulkin; Rachel Toth; Robert Gourlay; Julien Peltier; Nora Dieguez-Martinez; Matthias Trost; Jose M Lizcano; Marios P Stavridis; Greg M Findlay
Journal:  Biochem J       Date:  2021-12-10       Impact factor: 3.857

3.  Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.

Authors:  H Nayanga Thirimanne; Feinan Wu; Derek H Janssens; Jherek Swanger; Ahmed Diab; Heather M Feldman; Robert A Amezquita; Raphael Gottardo; Patrick J Paddison; Steven Henikoff; Bruce E Clurman
Journal:  Elife       Date:  2022-02-28       Impact factor: 8.713
  3 in total

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