Literature DB >> 18094723

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.

Markus Welcker1, Bruce E Clurman.   

Abstract

FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.

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Year:  2008        PMID： 18094723     DOI： 10.1038/nrc2290

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  547 in total

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Authors:  Jeffrey R Skaar; Julia K Pagan; Michele Pagano
Journal:  Nat Rev Drug Discov       Date:  2014-11-14       Impact factor: 84.694

2.  GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.

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Journal:  Blood       Date:  2011-12-05       Impact factor: 22.113

3.  Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.

Authors:  Xiaojing Tang; Stephen Orlicky; Tanja Mittag; Veronika Csizmok; Tony Pawson; Julie D Forman-Kay; Frank Sicheri; Mike Tyers
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4.  Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

Authors:  Jessica M Cassavaugh; Sarah A Hale; Theresa L Wellman; Alan K Howe; Cheung Wong; Karen M Lounsbury
Journal:  J Cell Biochem       Date:  2011-12       Impact factor: 4.429

Review 5.  Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.

Authors:  Monte S Willis; W H Davin Townley-Tilson; Eunice Y Kang; Jonathon W Homeister; Cam Patterson
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6.  The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1.

Authors:  Aurore Keutgens; Kateryna Shostak; Pierre Close; Xin Zhang; Benoît Hennuy; Marie Aussems; Jean-Paul Chapelle; Patrick Viatour; André Gothot; Marianne Fillet; Alain Chariot
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Review 7.  Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer.

Authors:  Jonathan D Black; Diana P English; Dana M Roque; Alessandro D Santin
Journal:  Womens Health (Lond)       Date:  2014-01

8.  Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.

Authors:  C Elizabeth Caldon; C Marcelo Sergio; Andrew Burgess; Andrew J Deans; Robert L Sutherland; Elizabeth A Musgrove
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

9.  Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells.

Authors:  C Elizabeth Caldon; C Marcelo Sergio; Robert L Sutherland; Elizabeth A Musgrove
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

10.  HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53.

Authors:  Yuwen Xue; Jian Chen; Hyun-Ho Choi; Liem Phan; Ping-Chieh Chou; Ruiying Zhao; Huiling Yang; Janice Santiago; Mo Liu; Giselle E Yeung; Sai-Ching J Yeung; Mong-Hong Lee
Journal:  Cell Cycle       Date:  2012-10-24       Impact factor: 4.534
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