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Literature DB >> 20919941

"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.

Lalitha Nayak¹, Zhiyong Lin, Mukesh K Jain.

Abstract

Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.

Entities: Gene

Mesh：

Substances：

Year: 2011 PMID： 20919941 PMCID： PMC3144441 DOI： 10.1089/ars.2010.3647

Source DB: PubMed Journal: Antioxid Redox Signal ISSN： 1523-0864 Impact factor: 8.401

110 in total

1. Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

Authors: Johannes V van Thienen; Joost O Fledderus; Rob J Dekker; Jakub Rohlena; Gerben A van Ijzendoorn; Neeltje A Kootstra; Hans Pannekoek; Anton J G Horrevoets
Journal: Cardiovasc Res Date: 2006-07-12 Impact factor: 10.787

2. Up-regulation of the KLF2 transcription factor by fluid shear stress requires nucleolin.

Authors: Justin P Huddleson; Nisar Ahmad; Jerry B Lingrel
Journal: J Biol Chem Date: 2006-03-29 Impact factor: 5.157

3. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium.

Authors: Rob J Dekker; Reinier A Boon; Mariska G Rondaij; Astrid Kragt; Oscar L Volger; Yvonne W Elderkamp; Joost C M Meijers; Jan Voorberg; Hans Pannekoek; Anton J G Horrevoets
Journal: Blood Date: 2006-02-02 Impact factor: 22.113

Review 4. Angiopoietins: a link between angiogenesis and inflammation.

Authors: Ulrike Fiedler; Hellmut G Augustin
Journal: Trends Immunol Date: 2006-10-12 Impact factor: 16.687

5. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.

Authors: Shivalingappa K Swamynathan; Jonathan P Katz; Klaus H Kaestner; Ruth Ashery-Padan; Mary A Crawford; Joram Piatigorsky
Journal: Mol Cell Biol Date: 2006-10-23 Impact factor: 4.272

6. Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

Authors: John S Lee; Qing Yu; Jordan T Shin; Eric Sebzda; Cara Bertozzi; Mei Chen; Patti Mericko; Matthias Stadtfeld; Diane Zhou; Lan Cheng; Thomas Graf; Calum A MacRae; John J Lepore; Cecilia W Lo; Mark L Kahn
Journal: Dev Cell Date: 2006-12 Impact factor: 12.270

7. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.

Authors: Eiji Warabi; Wakako Takabe; Takashi Minami; Kenji Inoue; Ken Itoh; Masayuki Yamamoto; Tetsuro Ishii; Tatsuhiko Kodama; Noriko Noguchi
Journal: Free Radic Biol Med Date: 2006-10-20 Impact factor: 7.376

8. Kruppel-like factor 2 regulates thymocyte and T-cell migration.

Authors: Corey M Carlson; Bart T Endrizzi; Jinghai Wu; Xiaojie Ding; Michael A Weinreich; Elizabeth R Walsh; Maqsood A Wani; Jerry B Lingrel; Kristin A Hogquist; Stephen C Jameson
Journal: Nature Date: 2006-07-20 Impact factor: 49.962

9. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells.

Authors: Yuhki Nakatake; Nobutaka Fukui; Yuko Iwamatsu; Shinji Masui; Kadue Takahashi; Rika Yagi; Kiyohito Yagi; Jun-Ichi Miyazaki; Ryo Matoba; Minoru S H Ko; Hitoshi Niwa
Journal: Mol Cell Biol Date: 2006-09-05 Impact factor: 4.272

10. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

45 in total

1. Regulation of Kruppel-like factor 2 (KLF2) in the pathogenesis of intracranial aneurysm induced by hemodynamics.

Authors: Xi Wu; Jian-Zhong Zhang; Peng-Fei Yang; Qing-Hai Huang; Jian-Min Liu
Journal: Am J Transl Res Date: 2017-12-15 Impact factor: 4.060

Review 2. The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.

Authors: Jessilyn Dunn; Rachel Simmons; Salim Thabet; Hanjoong Jo
Journal: Int J Biochem Cell Biol Date: 2015-05-13 Impact factor: 5.085

3. The FBW7-KLF2 axis regulates endothelial functions.

Authors: Yongchao Zhao; Yi Sun
Journal: Cell Res Date: 2013-04-09 Impact factor: 25.617

Review 4. Hemodynamics mediated epigenetic regulators in the pathogenesis of vascular diseases.

Authors: C L Karthika; S Ahalya; N Radhakrishnan; C C Kartha; S Sumi
Journal: Mol Cell Biochem Date: 2020-08-25 Impact factor: 3.396

Review 5. Krüpple-like factors in the central nervous system: novel mediators in stroke.

Authors: Ke-Jie Yin; Milton Hamblin; Yanbo Fan; Jifeng Zhang; Y Eugene Chen
Journal: Metab Brain Dis Date: 2013-12-15 Impact factor: 3.584

6. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.

Authors: Wei Wu; Han Xiao; Andrés Laguna-Fernandez; Guadalupe Villarreal; Kuei-Chun Wang; Greg G Geary; Yuzhi Zhang; Wei-Chi Wang; Hsien-Da Huang; Jing Zhou; Yi-Shuan Li; Shu Chien; Guillermo Garcia-Cardena; John Y-J Shyy
Journal: Circulation Date: 2011-07-18 Impact factor: 29.690