Literature DB >> 22673505

Tumor suppressor functions of FBW7 in cancer development and progression.

Zhiwei Wang1, Hiroyuki Inuzuka, Jiateng Zhong, Lixin Wan, Hidefumi Fukushima, Fazlul H Sarkar, Wenyi Wei.   

Abstract

FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7-knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22673505      PMCID： PMC3372850          DOI： 10.1016/j.febslet.2012.03.017

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  100 in total

1.  Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.

Authors:  Masayoshi Yada; Shigetsugu Hatakeyama; Takumi Kamura; Masaaki Nishiyama; Ryosuke Tsunematsu; Hiroyuki Imaki; Noriko Ishida; Fumihiko Okumura; Keiko Nakayama; Keiichi I Nakayama
Journal:  EMBO J       Date:  2004-04-22       Impact factor: 11.598

Review 2.  A continuum model for tumour suppression.

Authors:  Alice H Berger; Alfred G Knudson; Pier Paolo Pandolfi
Journal:  Nature       Date:  2011-08-10       Impact factor: 49.962

3.  The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.

Authors:  C Oberg; J Li; A Pauley; E Wolf; M Gurney; U Lendahl
Journal:  J Biol Chem       Date:  2001-07-18       Impact factor: 5.157

4.  SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.

Authors:  Mingjia Tan; Yongchao Zhao; Sun-Jung Kim; Margaret Liu; Lijun Jia; Thomas L Saunders; Yuan Zhu; Yi Sun
Journal:  Dev Cell       Date:  2011-11-23       Impact factor: 12.270

5.  Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

Authors:  Anders Sundqvist; Maria T Bengoechea-Alonso; Xin Ye; Vasyl Lukiyanchuk; Jianping Jin; J Wade Harper; Johan Ericsson
Journal:  Cell Metab       Date:  2005-06       Impact factor: 27.287

6.  Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.

Authors:  Jian-Hua Mao; Jesus Perez-Losada; Di Wu; Reyno Delrosario; Ryosuke Tsunematsu; Keiichi I Nakayama; Ken Brown; Sheila Bryson; Allan Balmain
Journal:  Nature       Date:  2004-12-09       Impact factor: 49.962

7.  Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.

Authors:  Mandayam O Nandan; Sengthong Chanchevalap; W Brian Dalton; Vincent W Yang
Journal:  FEBS Lett       Date:  2005-08-29       Impact factor: 4.124

8.  Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Authors:  Lei Fu; Young-Ae Kim; Xuerong Wang; Xiaoyun Wu; Ping Yue; Sagar Lonial; Fadlo R Khuri; Shi-Yong Sun
Journal:  Cancer Res       Date:  2009-11-17       Impact factor: 12.701

Review 9.  Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice.

Authors:  Ichiro Onoyama; Keiichi I Nakayama
Journal:  Cell Cycle       Date:  2008-11-05       Impact factor: 4.534

10.  CDC4/FBXW7 and the 'just enough' model of tumourigenesis.

Authors:  Hayley Davis; Ian Tomlinson
Journal:  J Pathol       Date:  2012-04-18       Impact factor: 7.996
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  88 in total

1.  miR-223/FBW7 axis regulates doxorubicin sensitivity through epithelial mesenchymal transition in non-small cell lung cancer.

Authors:  Renyuan Li; Shengjun Wu; Xin Chen; Hongfei Xu; Peng Teng; Weidong Li
Journal:  Am J Transl Res       Date:  2016-06-15       Impact factor: 4.060

2.  New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.

Authors:  John T Cunningham; Davide Ruggero
Journal:  Cancer Discov       Date:  2013-10       Impact factor: 39.397

3.  The canonical wnt signal restricts the glycogen synthase kinase 3/fbw7-dependent ubiquitination and degradation of eya1 phosphatase.

Authors:  Ye Sun; Xue Li
Journal:  Mol Cell Biol       Date:  2014-04-21       Impact factor: 4.272

4.  MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies.

Authors:  Ronit Vogt Sionov
Journal:  ISRN Hematol       Date:  2013-01-29

5.  FBXW7 is involved in Aurora B degradation.

Authors:  Chieh-Lin Teng; Yun-Chi Hsieh; Liem Phan; Jihyun Shin; Chris Gully; Guermarie Velazquez-Torres; Stephen Skerl; Sai-Ching J Yeung; Shih-Lan Hsu; Mong-Hong Lee
Journal:  Cell Cycle       Date:  2012-10-24       Impact factor: 4.534

6.  E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis.

Authors:  Zhenlu Chong; Chunjing Bao; Jia He; Tianxiao Chen; Lijia Zhong; Gaopeng Li; Huanle Li; Lutong Fang; Yinjing Song; Guoxiang Fu; Xuyan Yang; Lihua Lai; Yang Liu; Qingqing Wang
Journal:  Cell Mol Immunol       Date:  2018-10-01       Impact factor: 11.530

7.  Differential regulation of FBXW7 isoforms by various stress stimuli.

Authors:  Ronit Vogt Sionov; Efrat Netzer; Eitan Shaulian
Journal:  Cell Cycle       Date:  2013-09-24       Impact factor: 4.534

8.  mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.

Authors:  Junghui Koo; Ping Yue; Xingming Deng; Fadlo R Khuri; Shi-Yong Sun
Journal:  Mol Cell Biol       Date:  2015-04-27       Impact factor: 4.272

Review 9.  Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.

Authors:  Chuan-Ming Xie; Wenyi Wei; Yi Sun
Journal:  J Genet Genomics       Date:  2013-02-10       Impact factor: 4.275

Review 10.  Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.

Authors:  N C Correia; M-L Arcangeli; F Pflumio; J T Barata
Journal:  Leukemia       Date:  2016-06-13       Impact factor: 11.528
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