Literature DB >> 23508172

Target validation using chemical probes.

Mark E Bunnage1, Eugene L Piatnitski Chekler, Lyn H Jones.   

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Year:  2013        PMID: 23508172     DOI: 10.1038/nchembio.1197

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN: 1552-4450            Impact factor:   15.040


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  30 in total

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4.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

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5.  The art of the chemical probe.

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6.  Getting pharmaceutical R&D back on target.

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Journal:  Chem Biol       Date:  2011-06-24

Review 8.  The subcellular distribution of small molecules: from pharmacokinetics to synthetic biology.

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9.  Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Authors:  Kay Ahn; Sarah E Smith; Marya B Liimatta; David Beidler; Nalini Sadagopan; David T Dudley; Tim Young; Paul Wren; Yanhua Zhang; Steven Swaney; Keri Van Becelaere; Jacqueline L Blankman; Daniel K Nomura; Shobha N Bhattachar; Cory Stiff; Tyzoon K Nomanbhoy; Eranthie Weerapana; Douglas S Johnson; Benjamin F Cravatt
Journal:  J Pharmacol Exp Ther       Date:  2011-04-19       Impact factor: 4.030

10.  Identification of a novel retinoid by small molecule screening with zebrafish embryos.

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  108 in total

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5.  Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.

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Review 6.  Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.

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7.  Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.

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8.  Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.

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9.  Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

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Journal:  ACS Med Chem Lett       Date:  2016-03-15       Impact factor: 4.345

10.  CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.

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Journal:  ACS Med Chem Lett       Date:  2016-06-10       Impact factor: 4.345

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