PURPOSE: Respiratory motion makes hepatic ablation using high intensity focused ultrasound (HIFO) challenging. Previous HIFU liver treatment had required apnea induced during general anesthesia. We describe and test a system that allows treatment of the liver in the presence of breathing motion. METHODS: Mapping a signal from an external respiratory bellow to treatment locations within the liver allows the ultrasound transducer to be steered in real time to the target location. Using a moving phantom, three metrics were used to compare static, steered, and unsteered sonications: the area of sonications once a temperature rise of 15°C was achieved, the energy deposition required to reach that temperature, and the average rate of temperature rise during the first 10 s of sonication. Steered HIFU in vivo ablations of the porcine liver were also performed and compared to breath-hold ablations. RESULTS: For the last phantom metric, all groups were found to be statistically significantly different (P ≤ 0.003). However, in the other two metrics, the static and unsteered sonications were not statistically different (P > 0.9999). Steered in vivo HIFU ablations were not statistically significantly different from ablations during breath-holding. CONCLUSIONS: A system for performing HIFU steering during ablation of the liver with breathing motion is presented and shown to achieve results equivalent to ablation performed with breath-holding.
PURPOSE: Respiratory motion makes hepatic ablation using high intensity focused ultrasound (HIFO) challenging. Previous HIFU liver treatment had required apnea induced during general anesthesia. We describe and test a system that allows treatment of the liver in the presence of breathing motion. METHODS: Mapping a signal from an external respiratory bellow to treatment locations within the liver allows the ultrasound transducer to be steered in real time to the target location. Using a moving phantom, three metrics were used to compare static, steered, and unsteered sonications: the area of sonications once a temperature rise of 15°C was achieved, the energy deposition required to reach that temperature, and the average rate of temperature rise during the first 10 s of sonication. Steered HIFU in vivo ablations of the porcine liver were also performed and compared to breath-hold ablations. RESULTS: For the last phantom metric, all groups were found to be statistically significantly different (P ≤ 0.003). However, in the other two metrics, the static and unsteered sonications were not statistically different (P > 0.9999). Steered in vivo HIFU ablations were not statistically significantly different from ablations during breath-holding. CONCLUSIONS: A system for performing HIFU steering during ablation of the liver with breathing motion is presented and shown to achieve results equivalent to ablation performed with breath-holding.
Authors: Vincent Auboiroux; Lorena Petrusca; Magalie Viallon; Thomas Goget; Christoph D Becker; Rares Salomir Journal: Phys Med Biol Date: 2012-04-20 Impact factor: 3.609
Authors: C Tanner; Y Zur; K French; G Samei; J Strehlow; G Sat; H McLeod; G Houston; S Kozerke; G Székely; A Melzer; T Preusser Journal: Int J Comput Assist Radiol Surg Date: 2016-04-12 Impact factor: 2.924
Authors: Johanna M M van Breugel; Joost W Wijlemans; Hermanus H B Vaessen; Martijn de Greef; Chrit T W Moonen; Maurice A A J van den Bosch; Mario G Ries Journal: J Ther Ultrasound Date: 2016-07-29
Authors: Michael Schwenke; Jan Strehlow; Daniel Demedts; Sabrina Haase; Diego Barrios Romero; Sven Rothlübbers; Caroline von Dresky; Stephan Zidowitz; Joachim Georgii; Senay Mihcin; Mario Bezzi; Christine Tanner; Giora Sat; Yoav Levy; Jürgen Jenne; Matthias Günther; Andreas Melzer; Tobias Preusser Journal: J Ther Ultrasound Date: 2017-07-24