BACKGROUND/ OBJECTIVES: Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life. METHODS: In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires. RESULTS: Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean- or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total- or lean-fish consumption was not. CONCLUSIONS: During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms.
BACKGROUND/ OBJECTIVES: Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life. METHODS: In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires. RESULTS: Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean- or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total- or lean-fish consumption was not. CONCLUSIONS: During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms.
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Authors: Kourtney G Gardner; Tebeb Gebretsadik; Terryl J Hartman; Maria J Rosa; Frances A Tylavsky; Margaret A Adgent; Paul E Moore; Mehmet Kocak; Nicole R Bush; Robert L Davis; Kaja Z Lewinn; Rosalind J Wright; Kecia N Carroll Journal: J Allergy Clin Immunol Pract Date: 2019-10-15
Authors: Evelyn Xiu Ling Loo; Lynn Ong; Anne Goh; Ai-Ru Chia; Oon Hoe Teoh; Marjorelee T Colega; Yiong Huak Chan; Seang Mei Saw; Kenneth Kwek; Peter D Gluckman; Keith M Godfrey; Hugo Van Bever; Bee Wah Lee; Yap Seng Chong; Mary Foong-Fong Chong; Lynette Pei-Chi Shek Journal: Int Arch Allergy Immunol Date: 2017-06-28 Impact factor: 2.749
Authors: Hui Xing Lau; Sarah El-Heis; Qai Ven Yap; Yiong Huak Chan; Cheryl Pei Ting Tan; Neerja Karnani; Karen Mei Ling Tan; Elizabeth Huiwen Tham; Anne Eng Neo Goh; Oon Hoe Teoh; Kok Hian Tan; Johan Gunnar Eriksson; Yap Seng Chong; Mary Foong-Fong Chong; Hugo Van Bever; Bee Wah Lee; Lynette P Shek; Keith M Godfrey; Evelyn Xiu Ling Loo Journal: Clin Exp Allergy Date: 2021-06-24 Impact factor: 5.018