Kourtney G Gardner1, Tebeb Gebretsadik2, Terryl J Hartman3, Maria J Rosa4, Frances A Tylavsky5, Margaret A Adgent6, Paul E Moore7, Mehmet Kocak5, Nicole R Bush8, Robert L Davis9, Kaja Z Lewinn10, Rosalind J Wright11, Kecia N Carroll12. 1. Division of Allergy, Immunology, and Pulmonology, Vanderbilt University Medical Center, Nashville, Tenn; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn. 2. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tenn. 3. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga. 4. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY; Institute of Exposomic Research, Icahn School of Medicine at Mount Sinai, New York City, NY. 5. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tenn. 6. Division of General Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn. 7. Division of Allergy, Immunology, and Pulmonology, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn. 8. Department of Psychiatry, University of California, San Francisco, Calif; Department of Pediatrics, University of California, San Francisco, Calif. 9. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tenn. 10. Department of Psychiatry, University of California, San Francisco, Calif. 11. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, NY; Institute of Exposomic Research, Icahn School of Medicine at Mount Sinai, New York City, NY. 12. Division of General Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address: Kecia.Carroll@vumc.org.
Abstract
BACKGROUND: Atopic dermatitis is a common childhood disease, potentially influenced by prenatal nutritional exposures such as polyunsaturated fatty acids (PUFAs). OBJECTIVE: In a racially diverse cohort, we hypothesized that childhood atopic dermatitis would be associated with higher prenatal omega-6 (n-6) and lower omega-3 (n-3) PUFAs. METHODS: We included mother-child dyads, births 2006 to 2011, enrolled in the University of Tennessee Health Sciences Center Conditions Affecting Neurocognitive Development in Early Childhood cohort. Primary exposures included second trimester plasma n-3 and n-6 PUFA status and the ratio of the two (n-6:n-3). We assessed child current atopic dermatitis symptoms in the previous 12 months at age approximately 4 to 6 years. We investigated the association between PUFA exposures and atopic dermatitis using multivariable logistic regression, adjusting for potential confounders. We assessed for effect modification by maternal prenatal smoking, atopic disease history, and child sex. RESULTS: Among 1131 women, 67% were African American and 42% had an atopic disease history; 17% of children had atopic dermatitis. Higher prenatal n-6 PUFAs were associated with increased relative odds of child atopic dermatitis (adjusted odds ratio: 1.25; confidence interval: 1.01-1.54 per interquartile range difference), and interaction models demonstrated that this association was seen in dyads in which the women had a history of atopic disease. Neither prenatal n-3 PUFAs nor n-6:n-3 were associated with child atopic dermatitis. CONCLUSION: In this racially diverse cohort, higher second trimester n-6 PUFAs were associated with atopic dermatitis in children of women with atopy. PUFAs may represent a modifiable risk factor for atopic dermatitis, particularly in individuals with a familial predisposition.
BACKGROUND:Atopic dermatitis is a common childhood disease, potentially influenced by prenatal nutritional exposures such as polyunsaturated fatty acids (PUFAs). OBJECTIVE: In a racially diverse cohort, we hypothesized that childhood atopic dermatitis would be associated with higher prenatal omega-6 (n-6) and lower omega-3 (n-3) PUFAs. METHODS: We included mother-child dyads, births 2006 to 2011, enrolled in the University of Tennessee Health Sciences Center Conditions Affecting Neurocognitive Development in Early Childhood cohort. Primary exposures included second trimester plasma n-3 and n-6 PUFA status and the ratio of the two (n-6:n-3). We assessed child current atopic dermatitis symptoms in the previous 12 months at age approximately 4 to 6 years. We investigated the association between PUFA exposures and atopic dermatitis using multivariable logistic regression, adjusting for potential confounders. We assessed for effect modification by maternal prenatal smoking, atopic disease history, and child sex. RESULTS: Among 1131 women, 67% were African American and 42% had an atopic disease history; 17% of children hadatopic dermatitis. Higher prenatal n-6 PUFAs were associated with increased relative odds of childatopic dermatitis (adjusted odds ratio: 1.25; confidence interval: 1.01-1.54 per interquartile range difference), and interaction models demonstrated that this association was seen in dyads in which the women had a history of atopic disease. Neither prenatal n-3 PUFAs nor n-6:n-3 were associated with childatopic dermatitis. CONCLUSION: In this racially diverse cohort, higher second trimester n-6 PUFAs were associated with atopic dermatitis in children of women with atopy. PUFAs may represent a modifiable risk factor for atopic dermatitis, particularly in individuals with a familial predisposition.
Authors: Lefkothea-Stella Kremmyda; Maria Vlachava; Paul S Noakes; Norma D Diaper; Elizabeth A Miles; Philip C Calder Journal: Clin Rev Allergy Immunol Date: 2011-08 Impact factor: 8.667
Authors: Frederick B Palmer; Kanwaljeet J S Anand; J Carolyn Graff; Laura E Murphy; Yanhua Qu; Eszter Völgyi; Cynthia R Rovnaghi; Angela Moore; Quynh T Tran; Frances A Tylavsky Journal: J Pediatr Date: 2013-09-24 Impact factor: 4.406
Authors: S M Willers; G Devereux; L C A Craig; G McNeill; A H Wijga; W Abou El-Magd; S W Turner; P J Helms; A Seaton Journal: Thorax Date: 2007-03-27 Impact factor: 9.139
Authors: Stefanie Sausenthaler; Sibylle Koletzko; Beate Schaaf; Irina Lehmann; Michael Borte; Olf Herbarth; Andrea von Berg; H-Erich Wichmann; Joachim Heinrich Journal: Am J Clin Nutr Date: 2007-02 Impact factor: 7.045
Authors: Frances A Tylavsky; Mehmet Kocak; Laura E Murphy; J Carolyn Graff; Frederick B Palmer; Eszter Völgyi; Alicia M Diaz-Thomas; Robert J Ferry Journal: Nutrients Date: 2015-12-02 Impact factor: 5.717
Authors: Camilla C Senter; Nicole R Bush; Christine T Loftus; Adam A Szpiro; Annette L Fitzpatrick; Kecia N Carroll; Kaja Z LeWinn; W Alex Mason; Sheela Sathyanarayana; Oluwatobiloba A Akingbade; Catherine J Karr Journal: Int J Environ Res Public Health Date: 2021-09-15 Impact factor: 4.614
Authors: Matthias V Kopp; Cathleen Muche-Borowski; Michael Abou-Dakn; Birgit Ahrens; Kirsten Beyer; Katharina Blümchen; Petra Bubel; Adam Chaker; Monika Cremer; Regina Ensenauer; Michael Gerstlauer; Uwe Gieler; Inga-Marie Hübner; Fritz Horak; Ludger Klimek; Berthold V Koletzko; Sybille Koletzko; Susanne Lau; Thomas Lob-Corzilius; Katja Nemat; Eva M J Peters; Antonio Pizzulli; Imke Reese; Claudia Rolinck-Werninghaus; Elien Rouw; Bianca Schaub; Sebastian Schmidt; Jens-Oliver Steiß; Anne Kathrin Striegel; Zsolt Szépfalusi; Dietmar Schlembach; Thomas Spindler; Christian Taube; Valérie Trendelenburg; Regina Treudler; Ulrich Umpfenbach; Christian Vogelberg; Martin Wagenmann; Anke Weißenborn; Thomas Werfel; Margitta Worm; Helmut Sitter; Eckard Hamelmann Journal: Allergol Select Date: 2022-03-04