Literature DB >> 23435377

Bioavailability of phytochemicals and its enhancement by drug delivery systems.

Farrukh Aqil1, Radha Munagala1, Jeyaprakash Jeyabalan1, Manicka V Vadhanam2.   

Abstract

Issues of poor oral bioavailability of cancer chemopreventives have hindered progress in cancer prevention. Novel delivery systems that modulate the pharmacokinetics of existing drugs, such as nanoparticles, cyclodextrins, niosomes, liposomes and implants, could be used to enhance the delivery of chemopreventive agents to target sites. The development of new approaches in prevention and treatment of cancer could encompass new delivery systems for approved and newly investigated compounds. In this review, we discuss some of the delivery approaches that have already made an impact by either delivering a drug to target tissue or increasing its bioavailability by many fold.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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Year:  2013        PMID： 23435377      PMCID： PMC3815990          DOI： 10.1016/j.canlet.2013.02.032

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  135 in total

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Journal:  Curr Drug Metab       Date:  2010-10       Impact factor: 3.731

Review 4.  Drug-eluting polymer implants in cancer therapy.

Authors:  Agata A Exner; Gerald M Saidel
Journal:  Expert Opin Drug Deliv       Date:  2008-07       Impact factor: 6.648

5.  Effects of niosomal cisplatin and combination of the same with theophylline and with activated macrophages in murine B16F10 melanoma model.

Authors:  R P Gude; M G Jadhav; S G A Rao; A G Jagtap
Journal:  Cancer Biother Radiopharm       Date:  2002-04       Impact factor: 3.099

6.  Formulation and in vitro-in vivo evaluation of black raspberry extract-loaded PLGA/PLA injectable millicylindrical implants for sustained delivery of chemopreventive anthocyanins.

Authors:  Kashappa Goud H Desai; Karl F Olsen; Susan R Mallery; Gary D Stoner; Steven P Schwendeman
Journal:  Pharm Res       Date:  2010-02-11       Impact factor: 4.200

7.  Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.

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8.  Mannosylated niosomes as adjuvant-carrier system for oral genetic immunization against hepatitis B.

Authors:  Sanyog Jain; Paramjit Singh; Vivek Mishra; S P Vyas
Journal:  Immunol Lett       Date:  2005-04-25       Impact factor: 3.685

Review 9.  Itraconazole in cyclodextrin solution.

Authors:  D A Stevens
Journal:  Pharmacotherapy       Date:  1999-05       Impact factor: 4.705

Review 10.  Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery.

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Journal:  Nanomedicine       Date:  2009-05-15       Impact factor: 5.307
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Journal:  Biophys Rev       Date:  2015-10-10

Review 3.  Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease.

Authors:  Ning Zhao; Fang-Fang Guo; Ke-Qin Xie; Tao Zeng
Journal:  Cell Mol Life Sci       Date:  2018-06-11       Impact factor: 9.261

Review 4.  A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer.

Authors:  Atousa Haghi; Haniye Azimi; Roja Rahimi
Journal:  J Gastrointest Cancer       Date:  2017-12

Review 5.  Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials.

Authors:  Girish B Maru; Rasika R Hudlikar; Gaurav Kumar; Khushboo Gandhi; Manoj B Mahimkar
Journal:  World J Biol Chem       Date:  2016-02-26

Review 6.  Phytochemicals: Current strategies for treating breast cancer.

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Journal:  Oncol Lett       Date:  2018-03-20       Impact factor: 2.967

Review 7.  Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

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Journal:  Molecules       Date:  2020-11-14       Impact factor: 4.411

8.  Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.

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9.  Amelioration of Pterostilbene Antiproliferative, Proapoptotic, and Oxidant Potentials in Human Breast Cancer MCF7 Cells Using Zein Nanocomposites.

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Review 10.  Diet-derived small molecules (nutraceuticals) inhibit cellular proliferation by interfering with key oncogenic pathways: an overview of experimental evidence in cancer chemoprevention.

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