Literature DB >> 33202681

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Wamidh H Talib1, Izzeddin Alsalahat2, Safa Daoud2, Reem Fawaz Abutayeh2, Asma Ismail Mahmod1.   

Abstract

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basic and clinical research on developing alternative anticancer therapies.

Entities:  

Keywords:  alternative anticancer therapies; curcumin; natural products; plant extracts; thymoquinon

Mesh：

Substances：

Year:  2020        PMID： 33202681      PMCID： PMC7696819          DOI： 10.3390/molecules25225319

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  629 in total

1.  3,4',5-trans-Trimethoxystilbene; a natural analogue of resveratrol with enhanced anticancer potency.

Authors:  Fahad S Aldawsari; Carlos A Velázquez-Martínez
Journal:  Invest New Drugs       Date:  2015-02-28       Impact factor: 3.850

2.  A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma.

Authors:  Aminah Jatoi; Neil Ellison; Patrick A Burch; Jeff A Sloan; Shaker R Dakhil; Paul Novotny; Winston Tan; Tom R Fitch; Kendrith M Rowland; Charles Y F Young; Patrick J Flynn
Journal:  Cancer       Date:  2003-03-15       Impact factor: 6.860

3.  A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach.

Authors:  E Choan; Roanne Segal; Derek Jonker; Shawn Malone; Neil Reaume; Libni Eapen; Victor Gallant
Journal:  Urol Oncol       Date:  2005 Mar-Apr       Impact factor: 3.498

4.  Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.

Authors:  K Eckert; E Grabowska; R Stange; U Schneider; K Eschmann; H R Maurer
Journal:  Oncol Rep       Date:  1999 Nov-Dec       Impact factor: 3.906

5.  Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.

Authors:  Jan Hüsch; Janine Bohnet; Gert Fricker; Carsten Skarke; Christian Artaria; Giovanni Appendino; Manfred Schubert-Zsilavecz; Mona Abdel-Tawab
Journal:  Fitoterapia       Date:  2012-10-23       Impact factor: 2.882

6.  Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery of luteolin: An in vivo/in vitro evaluation.

Authors:  Jinli Li; Xudong Cheng; Yan Chen; Weiming He; Li Ni; Peihua Xiong; Minggang Wei
Journal:  Int J Pharm       Date:  2016-08-18       Impact factor: 5.875

7.  Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells.

Authors:  Hong Sheng; Toru Ogawa; Yoshimi Niwano; Keiichi Sasaki; Katsuro Tachibana
Journal:  J Oral Pathol Med       Date:  2018-02-19       Impact factor: 4.253

Review 8.  Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer.

Authors:  Nor Isnida Ismail; Iekhsan Othman; Faridah Abas; Nordin H Lajis; Rakesh Naidu
Journal:  Int J Mol Sci       Date:  2019-05-17       Impact factor: 5.923

9.  Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment.

Authors:  Qian Yu; Minda Zhang; Qidi Ying; Xin Xie; Shuwen Yue; Bending Tong; Qing Wei; Zhaoshi Bai; Lingman Ma
Journal:  Cell Death Dis       Date:  2019-03-04       Impact factor: 8.469

10.  Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings.

Authors:  Qiyi Feng; Yanping Liu; Jian Huang; Ke Chen; Jinxing Huang; Kai Xiao
Journal:  Sci Rep       Date:  2018-02-01       Impact factor: 4.379
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  12 in total

1.  Bioactive small-molecule constituents of Lao plants.

Authors:  Yulin Ren; Bethany G Elkington; Joshua M Henkin; Kongmany Sydara; A Douglas Kinghorn; Djaja D Soejarto
Journal:  J Med Plant Res       Date:  2021-12-31

2.  Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication.

Authors:  Carlo Genovese; Adriana Garozzo; Floriana D'Angeli; Giuseppe Antonio Malfa; Francesco Bellia; Barbara Tomasello; Daria Nicolosi; Roberta Malaguarnera; Simone Ronsisvalle; Fiorella Guadagni; Rosaria Acquaviva
Journal:  Cells       Date:  2022-05-19       Impact factor: 7.666

3.  Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells.

Authors:  Prabhu Ramamoorthy; Prasad Dandawate; Roy A Jensen; Shrikant Anant
Journal:  Biomedicines       Date:  2021-04-28

4.  In vitro performance of free and encapsulated bromelain.

Authors:  Janaína Artem Ataide; Letícia Caramori Cefali; Mariana Cecchetto Figueiredo; Lúcia Elaine de Oliveira Braga; Ana Lúcia Tasca Gois Ruiz; Mary Ann Foglio; Laura Oliveira-Nascimento; Priscila Gava Mazzola
Journal:  Sci Rep       Date:  2021-05-13       Impact factor: 4.379

Review 5.  Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer.

Authors:  Xuening Pang; Xiaoyi Zhang; Yuhuan Jiang; Quanzhong Su; Qun Li; Zichao Li
Journal:  Biomolecules       Date:  2021-01-21

Review 6.  Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention.

Authors:  Arif Jamal Siddiqui; Sadaf Jahan; Ritu Singh; Juhi Saxena; Syed Amir Ashraf; Andleeb Khan; Ranjay Kumar Choudhary; Santhanaraj Balakrishnan; Riadh Badraoui; Fevzi Bardakci; Mohd Adnan
Journal:  Biomed Res Int       Date:  2022-03-02       Impact factor: 3.411

7.  Geiparvarin Inhibits OS Metastasis through Upregulation of ANGPTL4 Expression by Inhibiting miRNA-3912-3p Expression.

Authors:  Fuling Jiang; Guang-Jie Wang; Ping Huang; Shu Chen; He Xiao; Liang Zhang; Hua Zou
Journal:  Evid Based Complement Alternat Med       Date:  2022-04-12       Impact factor: 2.650

8.  Ultrasonic-Assisted Extraction of Flavonoids from Juglans mandshurica Maxim.: Artificial Intelligence-Based Optimization, Kinetics Estimation, and Antioxidant Potential.

Authors:  Guodong Chu; Rui Liang; Chenmeng Wan; Jing Yang; Jing Li; Ruinan Wang; Linna Du; Ruixin Lin
Journal:  Molecules       Date:  2022-07-28       Impact factor: 4.927

9.  Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo.

Authors:  Huixia Fan; Xiaopeng Hao; Yuan Gao; Jian Yang; Aojun Liu; Yarui Su; Yong Xia
Journal:  Front Pharmacol       Date:  2022-07-22       Impact factor: 5.988

Review 10.  The Anti-Leukemic Activity of Natural Compounds.

Authors:  Coralia Cotoraci; Alina Ciceu; Alciona Sasu; Eftimie Miutescu; Anca Hermenean
Journal:  Molecules       Date:  2021-05-05       Impact factor: 4.411
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