Agata A Exner1, Gerald M Saidel. 1. Case Western Reserve University, Department of Radiology, 11100 Euclid Avenue, Cleveland, OH 44106-5056, USA. Agata.Exner@Case.edu
Abstract
BACKGROUND: Drug-eluting polymer implants present a compelling parenteral route of administration for cancer chemotherapy. With potential for minimally invasive, image-guided placement and highly localized drug release, these delivery systems are playing an increasingly important role in cancer management. This is particularly true as the use of labile proteins and other bioactive molecules is likely to increase in the upcoming years. OBJECTIVE: In this review, we present the current trends in the application of Pre-formed and in situ-forming systems as drug-eluting implants for cancer chemotherapy. METHODS: We outline the clinically available options as well as up-and-coming technologies and their advantages and challenges. We also describe ongoing related innovations with image-guided drug delivery, mathematical modeling of implanted delivery systems and implanted drug delivery in combination with other therapies. RESULTS/ CONCLUSION: Whether used alone or combined with other minimally invasive procedures, drug-eluting polymeric implants will play a significant role in the future of cancer management.
BACKGROUND: Drug-eluting polymer implants present a compelling parenteral route of administration for cancer chemotherapy. With potential for minimally invasive, image-guided placement and highly localized drug release, these delivery systems are playing an increasingly important role in cancer management. This is particularly true as the use of labile proteins and other bioactive molecules is likely to increase in the upcoming years. OBJECTIVE: In this review, we present the current trends in the application of Pre-formed and in situ-forming systems as drug-eluting implants for cancer chemotherapy. METHODS: We outline the clinically available options as well as up-and-coming technologies and their advantages and challenges. We also describe ongoing related innovations with image-guided drug delivery, mathematical modeling of implanted delivery systems and implanted drug delivery in combination with other therapies. RESULTS/ CONCLUSION: Whether used alone or combined with other minimally invasive procedures, drug-eluting polymeric implants will play a significant role in the future of cancer management.
Authors: Kelsey A Hopkins; Nicole Vike; Xin Li; Jacqueline Kennedy; Emma Simmons; Joseph Rispoli; Luis Solorio Journal: J Control Release Date: 2019-07-16 Impact factor: 9.776
Authors: Luis Solorio; Alexander M Olear; Haoyan Zhou; Ashlei C Beiswenger; Agata A Exner Journal: Drug Deliv Transl Res Date: 2012-02-01 Impact factor: 4.617
Authors: Luis Solorio; Brett M Babin; Ravi B Patel; Justyna Mach; Nami Azar; Agata A Exner Journal: J Control Release Date: 2010-01-11 Impact factor: 9.776