Literature DB >> 23430588

Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats.

Gemma Arjó1, Manuel Portero, Carme Piñol, Juan Viñas, Xavier Matias-Guiu, Teresa Capell, Andrew Bartholomaeus, Wayne Parrott, Paul Christou.   

Abstract

A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (Roundup™) and a Roundup-tolerant genetically modified variety of maize, concluding that both the herbicide and the maize varieties are toxic. Here we discuss the many errors and inaccuracies in the published article resulting in highly misleading conclusions, whose publication in the scientific literature and in the wider media has caused damage to the credibility of science and researchers in the field. We and many others have criticized the study, and in particular the manner in which the experiments were planned, implemented, analyzed, interpreted and communicated. The study appeared to sweep aside all known benchmarks of scientific good practice and, more importantly, to ignore the minimal standards of scientific and ethical conduct in particular concerning the humane treatment of experimental animals.

Entities:  

Mesh:

Substances:

Year:  2013        PMID: 23430588     DOI: 10.1007/s11248-013-9692-9

Source DB:  PubMed          Journal:  Transgenic Res        ISSN: 0962-8819            Impact factor:   2.788


  25 in total

Review 1.  Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review.

Authors:  Chelsea Snell; Aude Bernheim; Jean-Baptiste Bergé; Marcel Kuntz; Gérard Pascal; Alain Paris; Agnès E Ricroch
Journal:  Food Chem Toxicol       Date:  2011-12-03       Impact factor: 6.023

2.  Can -omics inform a food safety assessment?

Authors:  Bruce M Chassy
Journal:  Regul Toxicol Pharmacol       Date:  2010-05-23       Impact factor: 3.271

3.  Spontaneous endocrine tumors in Sprague-Dawley rats.

Authors:  H Suzuki; U Mohr; G Kimmerle
Journal:  J Cancer Res Clin Oncol       Date:  1979-10       Impact factor: 4.553

4.  Chronic toxicity and carcinogenicity of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat.

Authors:  A Otabe; T Fujieda; T Masuyama
Journal:  Food Chem Toxicol       Date:  2011-11       Impact factor: 6.023

5.  (1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system.

Authors:  Aalim M Weljie; Alla Bondareva; Ping Zang; Frank R Jirik
Journal:  J Biomol NMR       Date:  2011-03-04       Impact factor: 2.835

6.  Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats.

Authors:  Susan A MacKenzie; Ian Lamb; Jean Schmidt; Lora Deege; Michael J Morrisey; Marc Harper; Raymond J Layton; Lee M Prochaska; Craig Sanders; Mary Locke; Joel L Mattsson; Angel Fuentes; Bryan Delaney
Journal:  Food Chem Toxicol       Date:  2006-10-04       Impact factor: 6.023

7.  A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats.

Authors:  Xiao Yun He; Mao Zhi Tang; Yun Bo Luo; Xin Li; Si Shuo Cao; Jing Juan Yu; Bryan Delaney; Kun Lun Huang
Journal:  Food Chem Toxicol       Date:  2008-12-06       Impact factor: 6.023

8.  Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms.

Authors:  K P Keenan; K A Soper; P F Smith; G C Ballam; R L Clark
Journal:  Toxicol Pathol       Date:  1995 May-Jun       Impact factor: 1.902

Review 9.  Nutritionally enhanced crops and food security: scientific achievements versus political expediency.

Authors:  Gemma Farre; Richard M Twyman; Changfu Zhu; Teresa Capell; Paul Christou
Journal:  Curr Opin Biotechnol       Date:  2010-11-29       Impact factor: 9.740

10.  Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity.

Authors:  Gemma Arjó; Teresa Capell; Xavier Matias-Guiu; Changfu Zhu; Paul Christou; Carme Piñol
Journal:  Plant Biotechnol J       Date:  2012-08-29       Impact factor: 9.803

View more
  16 in total

1.  A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague-Dawley rats.

Authors:  Huan Song; Xiaoyun He; Shiying Zou; Teng Zhang; Yunbo Luo; Kunlun Huang; Zhen Zhu; Wentao Xu
Journal:  Transgenic Res       Date:  2014-11-01       Impact factor: 2.788

Review 2.  EFSA's scientific activities and achievements on the risk assessment of genetically modified organisms (GMOs) during its first decade of existence: looking back and ahead.

Authors:  Yann Devos; Jaime Aguilera; Zoltán Diveki; Ana Gomes; Yi Liu; Claudia Paoletti; Patrick du Jardin; Lieve Herman; Joe N Perry; Elisabeth Waigmann
Journal:  Transgenic Res       Date:  2013-08-21       Impact factor: 2.788

3.  Towards a more open debate about values in decision-making on agricultural biotechnology.

Authors:  Yann Devos; Olivier Sanvido; Joyce Tait; Alan Raybould
Journal:  Transgenic Res       Date:  2013-09-13       Impact factor: 2.788

Review 4.  New GMO regulations for old: Determining a new future for EU crop biotechnology.

Authors:  John Davison; Klaus Ammann
Journal:  GM Crops Food       Date:  2017-01-02       Impact factor: 3.074

Review 5.  The impact of Genetically Modified (GM) crops in modern agriculture: A review.

Authors:  Ruchir Raman
Journal:  GM Crops Food       Date:  2017-10-02       Impact factor: 3.074

6.  Retracting Inconclusive Research: Lessons from the Séralini GM Maize Feeding Study.

Authors:  David B Resnik
Journal:  J Agric Environ Ethics       Date:  2015-08       Impact factor: 1.727

Review 7.  The food and environmental safety of Bt crops.

Authors:  Michael S Koch; Jason M Ward; Steven L Levine; James A Baum; John L Vicini; Bruce G Hammond
Journal:  Front Plant Sci       Date:  2015-04-29       Impact factor: 5.753

8.  Inconclusive findings: now you see them, now you don't!

Authors:  Christopher J Portier; Lynn R Goldman; Bernard D Goldstein
Journal:  Environ Health Perspect       Date:  2014-02       Impact factor: 9.031

Review 9.  The use of whole food animal studies in the safety assessment of genetically modified crops: limitations and recommendations.

Authors:  Andrew Bartholomaeus; Wayne Parrott; Genevieve Bondy; Kate Walker
Journal:  Crit Rev Toxicol       Date:  2013-11       Impact factor: 5.635

10.  GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations.

Authors:  Alison L Van Eenennaam
Journal:  J Anim Sci Biotechnol       Date:  2013-09-25
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.