OBJECTIVE: Genome-wide association studies (GWAS) have identified 11 loci that influence the risk of developing colorectal cancer (CRC). Given that these studies were conducted in European Caucasian populations, it is not clear whether the results are relevant for populations with different ethnicities. The aim of this study was to examine these associations in a southern Chinese population. METHODS: Eleven single-nucleotide polymorphisms (SNPs), rs12701937, rs16892766, rs7014346, rs6983267, rs719725, rs10795668, rs3802842, rs4444235, rs9929218, rs10411210, and rs961253, were genotyped in 229 CRC patients and 267 controls using the MassArray SNP genotyping system. RESULTS: Evidence of an association with CRC was found for four of the 11 loci. The strongest associations were with rs4444235 and rs961253, with significant odds ratios close to those reported in previous GWAS. Among these four loci, rs719725 and rs4444235 were significantly associated with female gender, rs3802842, rs961253, and rs4444235 with early disease onset, and rs3802842 with later disease onset. However, no associations with CRC risk were detected for six other loci (rs9929218, rs10411210, rs12701937, rs7014346, rs6983267, and rs10795668), and one SNP, rs16892766, was not polymorphic in any of the study participants. CONCLUSION: The rs4444235 and rs961253 loci are strongly associated with the risk of CRC in southern Chinese.
OBJECTIVE: Genome-wide association studies (GWAS) have identified 11 loci that influence the risk of developing colorectal cancer (CRC). Given that these studies were conducted in European Caucasian populations, it is not clear whether the results are relevant for populations with different ethnicities. The aim of this study was to examine these associations in a southern Chinese population. METHODS: Eleven single-nucleotide polymorphisms (SNPs), rs12701937, rs16892766, rs7014346, rs6983267, rs719725, rs10795668, rs3802842, rs4444235, rs9929218, rs10411210, and rs961253, were genotyped in 229 CRC patients and 267 controls using the MassArray SNP genotyping system. RESULTS: Evidence of an association with CRC was found for four of the 11 loci. The strongest associations were with rs4444235 and rs961253, with significant odds ratios close to those reported in previous GWAS. Among these four loci, rs719725 and rs4444235 were significantly associated with female gender, rs3802842, rs961253, and rs4444235 with early disease onset, and rs3802842 with later disease onset. However, no associations with CRC risk were detected for six other loci (rs9929218, rs10411210, rs12701937, rs7014346, rs6983267, and rs10795668), and one SNP, rs16892766, was not polymorphic in any of the study participants. CONCLUSION: The rs4444235 and rs961253 loci are strongly associated with the risk of CRC in southern Chinese.
Entities:
Keywords:
Association study; Chinese; Colorectal cancer; SNP
Authors: Juul T Wijnen; Richard M Brohet; Ronald van Eijk; Shanty Jagmohan-Changur; Anneke Middeldorp; Carli M Tops; Mario van Puijenbroek; Margreet G E M Ausems; Encarna Gómez García; Frederik J Hes; Nicoline Hoogerbrugge; Fred H Menko; Theo A M van Os; Rolf H Sijmons; Senno Verhoef; Anja Wagner; Fokko M Nagengast; Jan H Kleibeuker; Peter Devilee; Hans Morreau; David Goldgar; Ian P Tomlinson; Richard S Houlston; Tom van Wezel; Hans F A Vasen Journal: Gastroenterology Date: 2008-09-25 Impact factor: 22.682
Authors: Alan M Pittman; Emily Webb; Luis Carvajal-Carmona; Kimberley Howarth; Maria Chiara Di Bernardo; Peter Broderick; Sarah Spain; Axel Walther; Amy Price; Kate Sullivan; Philip Twiss; Sarah Fielding; Andrew Rowan; Emma Jaeger; Jayaram Vijayakrishnan; Ian Chandler; Steven Penegar; Mobshra Qureshi; Steven Lubbe; Enric Domingo; Zoe Kemp; Ella Barclay; Wendy Wood; Lynn Martin; Maggie Gorman; Huw Thomas; Julian Peto; Timothy Bishop; Richard Gray; Eamonn R Maher; Anneke Lucassen; David Kerr; Gareth R Evans; Tom van Wezel; Hans Morreau; Juul T Wijnen; John L Hopper; Melissa C Southey; Graham G Giles; Gianluca Severi; Sergi Castellví-Bel; Clara Ruiz-Ponte; Angel Carracedo; Antoni Castells; Asta Försti; Kari Hemminki; Pavel Vodicka; Alessio Naccarati; Lara Lipton; Judy W C Ho; K K Cheng; Pak C Sham; J Luk; Jose A G Agúndez; Jose M Ladero; Miguel de la Hoya; Trinidad Caldés; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri A Aaltonen; Jean-Baptiste Cazier; Ian P M Tomlinson; Richard S Houlston Journal: Hum Mol Genet Date: 2008-08-27 Impact factor: 6.150
Authors: Ian P M Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Kimberley Howarth; Alan M Pittman; Sarah Spain; Steven Lubbe; Axel Walther; Kate Sullivan; Emma Jaeger; Sarah Fielding; Andrew Rowan; Jayaram Vijayakrishnan; Enric Domingo; Ian Chandler; Zoe Kemp; Mobshra Qureshi; Susan M Farrington; Albert Tenesa; James G D Prendergast; Rebecca A Barnetson; Steven Penegar; Ella Barclay; Wendy Wood; Lynn Martin; Maggie Gorman; Huw Thomas; Julian Peto; D Timothy Bishop; Richard Gray; Eamonn R Maher; Anneke Lucassen; David Kerr; D Gareth R Evans; Clemens Schafmayer; Stephan Buch; Henry Völzke; Jochen Hampe; Stefan Schreiber; Ulrich John; Thibaud Koessler; Paul Pharoah; Tom van Wezel; Hans Morreau; Juul T Wijnen; John L Hopper; Melissa C Southey; Graham G Giles; Gianluca Severi; Sergi Castellví-Bel; Clara Ruiz-Ponte; Angel Carracedo; Antoni Castells; Asta Försti; Kari Hemminki; Pavel Vodicka; Alessio Naccarati; Lara Lipton; Judy W C Ho; K K Cheng; Pak C Sham; J Luk; Jose A G Agúndez; Jose M Ladero; Miguel de la Hoya; Trinidad Caldés; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri Aaltonen; Jean-Baptiste Cazier; Harry Campbell; Malcolm G Dunlop; Richard S Houlston Journal: Nat Genet Date: 2008-03-30 Impact factor: 38.330
Authors: Albert Tenesa; Susan M Farrington; James G D Prendergast; Mary E Porteous; Marion Walker; Naila Haq; Rebecca A Barnetson; Evropi Theodoratou; Roseanne Cetnarskyj; Nicola Cartwright; Colin Semple; Andrew J Clark; Fiona J L Reid; Lorna A Smith; Kostas Kavoussanakis; Thibaud Koessler; Paul D P Pharoah; Stephan Buch; Clemens Schafmayer; Jürgen Tepel; Stefan Schreiber; Henry Völzke; Carsten O Schmidt; Jochen Hampe; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Stefan Wilkening; Federico Canzian; Gabriel Capella; Victor Moreno; Ian J Deary; John M Starr; Ian P M Tomlinson; Zoe Kemp; Kimberley Howarth; Luis Carvajal-Carmona; Emily Webb; Peter Broderick; Jayaram Vijayakrishnan; Richard S Houlston; Gad Rennert; Dennis Ballinger; Laura Rozek; Stephen B Gruber; Koichi Matsuda; Tomohide Kidokoro; Yusuke Nakamura; Brent W Zanke; Celia M T Greenwood; Jagadish Rangrej; Rafal Kustra; Alexandre Montpetit; Thomas J Hudson; Steven Gallinger; Harry Campbell; Malcolm G Dunlop Journal: Nat Genet Date: 2008-03-30 Impact factor: 38.330
Authors: Sonia S Kupfer; Jeffrey R Anderson; Stanley Hooker; Andrew Skol; Rick A Kittles; Temitope O Keku; Robert S Sandler; Nathan A Ellis Journal: Gastroenterology Date: 2010-07-24 Impact factor: 22.682
Authors: Richard S Houlston; Emily Webb; Peter Broderick; Alan M Pittman; Maria Chiara Di Bernardo; Steven Lubbe; Ian Chandler; Jayaram Vijayakrishnan; Kate Sullivan; Steven Penegar; Luis Carvajal-Carmona; Kimberley Howarth; Emma Jaeger; Sarah L Spain; Axel Walther; Ella Barclay; Lynn Martin; Maggie Gorman; Enric Domingo; Ana S Teixeira; David Kerr; Jean-Baptiste Cazier; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri A Aaltonen; Ian P M Tomlinson; Susan M Farrington; Albert Tenesa; James G D Prendergast; Rebecca A Barnetson; Roseanne Cetnarskyj; Mary E Porteous; Paul D P Pharoah; Thibaud Koessler; Jochen Hampe; Stephan Buch; Clemens Schafmayer; Jurgen Tepel; Stefan Schreiber; Henry Völzke; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Brent W Zanke; Alexandre Montpetit; Thomas J Hudson; Steven Gallinger; Harry Campbell; Malcolm G Dunlop Journal: Nat Genet Date: 2008-11-16 Impact factor: 38.330
Authors: Ian Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Zoe Kemp; Sarah Spain; Steven Penegar; Ian Chandler; Maggie Gorman; Wendy Wood; Ella Barclay; Steven Lubbe; Lynn Martin; Gabrielle Sellick; Emma Jaeger; Richard Hubner; Ruth Wild; Andrew Rowan; Sarah Fielding; Kimberley Howarth; Andrew Silver; Wendy Atkin; Kenneth Muir; Richard Logan; David Kerr; Elaine Johnstone; Oliver Sieber; Richard Gray; Huw Thomas; Julian Peto; Jean-Baptiste Cazier; Richard Houlston Journal: Nat Genet Date: 2007-07-08 Impact factor: 38.330
Authors: J W Ho; S-c Choi; Y-f Lee; T C Hui; S S Cherny; M-M Garcia-Barceló; L Carvajal-Carmona; R Liu; S-h To; T-k Yau; C C Chung; C C Yau; S M Hui; P Y Lau; C-h Yuen; Y-w Wong; S Ho; S S Fung; I P Tomlinson; R S Houlston; K K Cheng; P C Sham Journal: Br J Cancer Date: 2010-12-21 Impact factor: 7.640
Authors: Hansong Wang; Christopher A Haiman; Terrilea Burnett; Barbara K Fortini; Laurence N Kolonel; Brian E Henderson; Lisa B Signorello; William J Blot; Temitope O Keku; Sonja I Berndt; Polly A Newcomb; Mala Pande; Christopher I Amos; Dee W West; Graham Casey; Robert S Sandler; Robert Haile; Daniel O Stram; Loïc Le Marchand Journal: Hum Mol Genet Date: 2013-07-12 Impact factor: 6.150