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Literature DB >> 23358219

The burden of faulty proofreading in colon cancer.

Abstract

Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23358219 DOI： 10.1038/ng.2540

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

9 in total

1. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.

Authors: Ranga N Venkatesan; Jessica J Hsu; Nicole A Lawrence; Bradley D Preston; Lawrence A Loeb
Journal: J Biol Chem Date: 2005-12-12 Impact factor: 5.157

Review 2. Molecular genetics of colorectal cancer.

Authors: Eric R Fearon
Journal: Annu Rev Pathol Date: 2011 Impact factor: 23.472

3. Recurrent R-spondin fusions in colon cancer.

Authors: Somasekar Seshagiri; Eric W Stawiski; Steffen Durinck; Zora Modrusan; Elaine E Storm; Caitlin B Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S Jaiswal; Joseph Guillory; Connie Ha; Gerrit J P Dijkgraaf; Jeremy Stinson; Florian Gnad; Melanie A Huntley; Jeremiah D Degenhardt; Peter M Haverty; Richard Bourgon; Weiru Wang; Hartmut Koeppen; Robert Gentleman; Timothy K Starr; Zemin Zhang; David A Largaespada; Thomas D Wu; Frederic J de Sauvage
Journal: Nature Date: 2012-08-30 Impact factor: 49.962

4. Global cancer statistics.

Authors: Ahmedin Jemal; Freddie Bray; Melissa M Center; Jacques Ferlay; Elizabeth Ward; David Forman
Journal: CA Cancer J Clin Date: 2011-02-04 Impact factor: 508.702

Review 5. DNA replication fidelity and cancer.

Authors: Bradley D Preston; Tina M Albertson; Alan J Herr
Journal: Semin Cancer Biol Date: 2010-10-15 Impact factor: 15.707

6. Inheritance of Colorectal Cancer.

Authors: Randall Burt
Journal: Drug Discov Today Dis Mech Date: 2007

7. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.

Authors: Tina M Albertson; Masanori Ogawa; James M Bugni; Laura E Hays; Yang Chen; Yanping Wang; Piper M Treuting; John A Heddle; Robert E Goldsby; Bradley D Preston
Journal: Proc Natl Acad Sci U S A Date: 2009-09-24 Impact factor: 11.205

8. Comprehensive molecular characterization of human colon and rectal cancer.

Authors:
Journal: Nature Date: 2012-07-18 Impact factor: 49.962

9. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Authors: Claire Palles; Jean-Baptiste Cazier; Kimberley M Howarth; Enric Domingo; Angela M Jones; Peter Broderick; Zoe Kemp; Sarah L Spain; Estrella Guarino; Estrella Guarino Almeida; Israel Salguero; Amy Sherborne; Daniel Chubb; Luis G Carvajal-Carmona; Yusanne Ma; Kulvinder Kaur; Sara Dobbins; Ella Barclay; Maggie Gorman; Lynn Martin; Michal B Kovac; Sean Humphray; Anneke Lucassen; Christopher C Holmes; David Bentley; Peter Donnelly; Jenny Taylor; Christos Petridis; Rebecca Roylance; Elinor J Sawyer; David J Kerr; Susan Clark; Jonathan Grimes; Stephen E Kearsey; Huw J W Thomas; Gilean McVean; Richard S Houlston; Ian Tomlinson
Journal: Nat Genet Date: 2012-12-23 Impact factor: 38.330

9 in total

15 in total

Review 1. Genetic architecture of colorectal cancer.

Authors: Ulrike Peters; Stephanie Bien; Niha Zubair
Journal: Gut Date: 2015-07-17 Impact factor: 23.059

2. Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.

Authors: Tony M Mertz; Sushma Sharma; Andrei Chabes; Polina V Shcherbakova
Journal: Proc Natl Acad Sci U S A Date: 2015-03-31 Impact factor: 11.205

3. Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient.

Authors: Kiyoshi Yamaguchi; Eigo Shimizu; Rui Yamaguchi; Seiya Imoto; Mitsuhiro Komura; Seira Hatakeyama; Rei Noguchi; Kiyoko Takane; Tsuneo Ikenoue; Yoshimasa Gohda; Hideaki Yano; Satoru Miyano; Yoichi Furukawa
Journal: J Hum Genet Date: 2019-05-14 Impact factor: 3.172

Review 4. Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.

Authors: Stephanie R Barbari; Polina V Shcherbakova
Journal: DNA Repair (Amst) Date: 2017-06-09

Review 5. New genes emerging for colorectal cancer predisposition.

Authors: Clara Esteban-Jurado; Pilar Garre; Maria Vila; Juan José Lozano; Anna Pristoupilova; Sergi Beltrán; Anna Abulí; Jenifer Muñoz; Francesc Balaguer; Teresa Ocaña; Antoni Castells; Josep M Piqué; Angel Carracedo; Clara Ruiz-Ponte; Xavier Bessa; Montserrat Andreu; Luis Bujanda; Trinidad Caldés; Sergi Castellví-Bel
Journal: World J Gastroenterol Date: 2014-02-28 Impact factor: 5.742

Review 6. Sphingolipids in colon cancer.

Authors: Mónica García-Barros; Nicolas Coant; Jean-Philip Truman; Ashley J Snider; Yusuf A Hannun
Journal: Biochim Biophys Acta Date: 2013-09-21

Review 7. When Genome Maintenance Goes Badly Awry.

Authors: Elizabeth M Kass; Mary Ellen Moynahan; Maria Jasin
Journal: Mol Cell Date: 2016-06-02 Impact factor: 17.970

8. Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.

Authors: Fadwa A Elsayed; C Marleen Kets; Dina Ruano; Brendy van den Akker; Arjen R Mensenkamp; Melanie Schrumpf; Maartje Nielsen; Juul T Wijnen; Carli M Tops; Marjolijn J Ligtenberg; Hans F A Vasen; Frederik J Hes; Hans Morreau; Tom van Wezel
Journal: Eur J Hum Genet Date: 2014-11-05 Impact factor: 4.246

Review 9. Clinical application of genetics in management of colorectal cancer.

Authors: Eun Ran Kim; Young-Ho Kim
Journal: Intest Res Date: 2014-07-25

Review 10. Replicative DNA polymerase mutations in cancer.

Authors: Ellen Heitzer; Ian Tomlinson
Journal: Curr Opin Genet Dev Date: 2014-02-26 Impact factor: 5.578