Literature DB >> 23334431

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis.

Dana K Winter1, David L Sloman, John A Porco.   

Abstract

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.

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Year:  2013        PMID： 23334431      PMCID： PMC3615431          DOI： 10.1039/c3np20122h

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  34 in total

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Authors:  W M Maiese; M P Lechevalier; H A Lechevalier; J Korshalla; J Goodman; M J Wildey; N Kuck; M Greenstein
Journal:  J Antibiot (Tokyo)       Date:  1989-06       Impact factor: 2.649

Review 2.  Xanthones from fungi, lichens, and bacteria: the natural products and their synthesis.

Authors:  Kye-Simeon Masters; Stefan Bräse
Journal:  Chem Rev       Date:  2012-05-22       Impact factor: 60.622

3.  Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin.

Authors:  Weike Zhang; Lu Wang; Lingxin Kong; Tao Wang; Yiwen Chu; Zixin Deng; Delin You
Journal:  Chem Biol       Date:  2012-03-23

4.  Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.

Authors:  M Chu; I Truumees; R Mierzwa; J Terracciano; M Patel; D Loebenberg; J J Kaminski; P Das; M S Puar
Journal:  J Nat Prod       Date:  1997-05       Impact factor: 4.050

5.  Total synthesis and absolute stereochemical assignment of kibdelone C.

Authors:  David L Sloman; Jeffrey W Bacon; John A Porco
Journal:  J Am Chem Soc       Date:  2011-06-15       Impact factor: 15.419

Review 6.  The NCI60 human tumour cell line anticancer drug screen.

Authors:  Robert H Shoemaker
Journal:  Nat Rev Cancer       Date:  2006-10       Impact factor: 60.716

7.  First stereoselective total synthesis of FD-594 aglycon.

Authors:  Ritsuki Masuo; Ken Ohmori; Lukas Hintermann; Saki Yoshida; Keisuke Suzuki
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

8.  Actinoplanones C, D, E, F and G, new cytotoxic polycyclic xanthones from Actinoplanes sp.

Authors:  K Kobayashi; C Nishino; J Ohya; S Sato; T Mikawa; Y Shiobara; M Kodama
Journal:  J Antibiot (Tokyo)       Date:  1988-06       Impact factor: 2.649

9.  Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.

Authors:  Aaron J Peoples; Qibo Zhang; William P Millett; Mithra T Rothfeder; Brian C Pescatore; Anne A Madden; Losee L Ling; Charles M Moore
Journal:  J Antibiot (Tokyo)       Date:  2008-07       Impact factor: 2.649

10.  Structure of cervinomycin, a novel xantone antibiotic active against anaerobe and mycoplasma.

Authors:  A Nakagawa; S Omura; K Kushida; H Shimizu; G Lukacs
Journal:  J Antibiot (Tokyo)       Date:  1987-03       Impact factor: 2.649
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  19 in total

1.  Total Synthesis of the Aglycone of IB-00208.

Authors:  Daniel Knueppel; Jingyue Yang; Bo Cheng; Douglas Mans; Stephen F Martin
Journal:  Tetrahedron       Date:  2015-09-02       Impact factor: 2.457

2.  Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1.

Authors:  Sifan Wu; Tingting Huang; Dan Xie; Jing Wo; Xiaozheng Wang; Zixin Deng; Shuangjun Lin
Journal:  J Antibiot (Tokyo)       Date:  2016-06-22       Impact factor: 2.649

3.  Bioguided isolation, characterization and media optimization for production of Lysolipins by actinomycete as antimicrobial compound against Xanthomonas citri subsp. citri.

Authors:  Júlia Pereira Rodrigues; Ana Paula Ferranti Peti; Fernanda Salés Figueiró; Izadora de Souza Rocha; Vinicius Ricardo Acquaro Junior; Tamires Garcia Silva; Itamar Soares de Melo; Franklin Behlau; Luiz Alberto Beraldo Moraes
Journal:  Mol Biol Rep       Date:  2018-10-11       Impact factor: 2.316

4.  Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue.

Authors:  Dana K Winter; Mary Ann Endoma-Arias; Tomas Hudlicky; John A Beutler; John A Porco
Journal:  J Org Chem       Date:  2013-07-23       Impact factor: 4.354

5.  Cervinomycins C1-4 with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980.

Authors:  Xiaowen Hu; Wei Sun; Shufen Li; LinLi Li; Liyan Yu; Hongyu Liu; Xuefu You; Bingya Jiang; Linzhuan Wu
Journal:  J Antibiot (Tokyo)       Date:  2020-07-03       Impact factor: 2.649

6.  Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.

Authors:  Janjira Rujirawanich; Soyeon Kim; Ai-Jun Ma; John R Butler; Yizhong Wang; Chao Wang; Michael Rosen; Bruce Posner; Deepak Nijhawan; Joseph M Ready
Journal:  J Am Chem Soc       Date:  2016-08-09       Impact factor: 15.419

7.  Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α.

Authors:  Yizhong Wang; Chao Wang; John R Butler; Joseph M Ready
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-22       Impact factor: 15.336

8.  Flavin Adenine Dinucleotide-Dependent Halogenase XanH and Engineering of Multifunctional Fusion Halogenases.

Authors:  Lingxin Kong; Qing Wang; Zixin Deng; Delin You
Journal:  Appl Environ Microbiol       Date:  2020-09-01       Impact factor: 4.792

9.  Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications.

Authors:  Daniel W Klosowski; J Caleb Hethcox; Daniel H Paull; Chao Fang; James R Donald; Christopher R Shugrue; Andrew D Pansick; Stephen F Martin
Journal:  J Org Chem       Date:  2018-05-22       Impact factor: 4.354

10.  Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer.

Authors:  Zhengxiang Xia; Zhongyan Tang
Journal:  ACS Omega       Date:  2021-04-14
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