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Literature DB >> 18776658

Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.

Aaron J Peoples¹, Qibo Zhang, William P Millett, Mithra T Rothfeder, Brian C Pescatore, Anne A Madden, Losee L Ling, Charles M Moore.

Abstract

Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain. This producing strain was obtained using an in situ diffusion chamber that facilitates the cultivation of soil microorganisms. The structures of neocitreamicins I and II were elucidated using UV, MS, and NMR data, and found to be related to the polycyclic xanthone antibiotics of the citreamicin class. The neocitreamicins showed in vitro activity against Gram-positive bacteria including strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 18776658 PMCID： PMC2720590 DOI： 10.1038/ja.2008.62

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

7 in total

1. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment.

Authors: T Kaeberlein; K Lewis; S S Epstein
Journal: Science Date: 2002-05-10 Impact factor: 47.728

Review 2. Review and re-analysis of domain-specific 16S primers.

Authors: G C Baker; J J Smith; D A Cowan
Journal: J Microbiol Methods Date: 2003-12 Impact factor: 2.363

3. LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity.

Authors: W M Maiese; M P Lechevalier; H A Lechevalier; J Korshalla; J Goodman; M J Wildey; N Kuck; M Greenstein
Journal: J Antibiot (Tokyo) Date: 1989-06 Impact factor: 2.649

4. Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov.

Authors: S Omura; Y Iwai; K Hinotozawa; Y Takahashi; J Kato; A Nakagawa; A Hirano; H Shimizu; K Haneda
Journal: J Antibiot (Tokyo) Date: 1982-06 Impact factor: 2.649

5. Citreamicins, novel antibiotics from Micromonospora citrea: isolation, characterization, and structure determination.

Authors: G T Carter; J A Nietsche; D R Williams; D B Borders
Journal: J Antibiot (Tokyo) Date: 1990-05 Impact factor: 2.649

6. Actinoplanones A and B, new cytotoxic polycyclic xanthones from Actinoplanes sp.

Authors: K Kobayashi; C Nishino; J Ohya; S Sato; T Mikawa; Y Shiobara; M Kodama
Journal: J Antibiot (Tokyo) Date: 1988-04 Impact factor: 2.649

7. The effect of methylation inhibitors on citreamicin biosynthesis in Micromonospora citrea.

Authors: C J Pearce; G T Carter; J A Nietsche; D B Borders; M Greenstein; W M Maiese
Journal: J Antibiot (Tokyo) Date: 1991-11 Impact factor: 2.649

7 in total

9 in total

Review 1. A comprehensive review of glycosylated bacterial natural products.

Authors: Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal: Chem Soc Rev Date: 2015-11-07 Impact factor: 54.564

2. Genome-based analysis of the type II PKS biosynthesis pathway of xanthones in Streptomyces caelestis and their antifungal activity.

Authors: Ling-Li Liu; Hong-Fei Liu; Hua-Hua Gao; Zheng-Zhong Yang; Xiao-Lan Feng; Jin-Ming Gao; Jian-Bang Zhao
Journal: RSC Adv Date: 2019-11-15 Impact factor: 4.036

Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.

1. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment.

Review 2. Review and re-analysis of domain-specific 16S primers.

3. LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity.

4. Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov.

5. Citreamicins, novel antibiotics from Micromonospora citrea: isolation, characterization, and structure determination.

6. Actinoplanones A and B, new cytotoxic polycyclic xanthones from Actinoplanes sp.

7. The effect of methylation inhibitors on citreamicin biosynthesis in Micromonospora citrea.

Review 1. A comprehensive review of glycosylated bacterial natural products.

2. Genome-based analysis of the type II PKS biosynthesis pathway of xanthones in Streptomyces caelestis and their antifungal activity.

Review 3. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis.

Review 4. Concepts and Methods to Access Novel Antibiotics from Actinomycetes.

Review 5. Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Review 6. Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes.

7. Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis.

8. New capoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025.

Review 9. Bioactive Marine Xanthones: A Review.