| Literature DB >> 23834060 |
Dana K Winter1, Mary Ann Endoma-Arias, Tomas Hudlicky, John A Beutler, John A Porco.
Abstract
The total synthesis of kibdelone A has been accomplished via In(III)-catalyzed arylation of a heterocyclic quinone monoketal and iodine-mediated oxidative photochemical electrocyclization for construction of the ABCD ring moiety. Enzymatic dihydroxylation of methyl 2-halobenzoate substrates was employed for synthesis of activated 2-halo-cyclohexene F-ring fragments. A one pot oxa-Michael/Friedel-Crafts process allowed access to the first simplified DEF ring analogues of the kibdelones.Entities:
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Year: 2013 PMID： 23834060 PMCID： PMC3773511 DOI： 10.1021/jo401169z
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354