Literature DB >> 9170295

Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.

M Chu1, I Truumees, R Mierzwa, J Terracciano, M Patel, D Loebenberg, J J Kaminski, P Das, M S Puar.   

Abstract

A novel antifungal agent, Sch 54445, was isolated from the fermentation broth of an Actinoplanes species. Sch 54445 was identified as a polycyclic xanthone related to the albofungin family of compounds on the basis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.

Entities:  

Mesh:

Substances:

Year:  1997        PMID: 9170295     DOI: 10.1021/np960737v

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  6 in total

1.  Great diversity of KSα sequences from bat-associated microbiota suggests novel sources of uncharacterized natural products.

Authors:  Paris S Salazar-Hamm; Jennifer J Marshall Hathaway; Ara S Winter; Nicole A Caimi; Debbie C Buecher; Ernest W Valdez; Diana E Northup
Journal:  FEMS Microbes       Date:  2022-04-18

2.  Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model.

Authors:  Rubin Yao; Lirong Ren; Shiyong Wang; Ming Zhang; Kaishun Yang
Journal:  Transl Neurosci       Date:  2021-03-17       Impact factor: 1.757

3.  A marine microbiome antifungal targets urgent-threat drug-resistant fungi.

Authors:  Fan Zhang; Miao Zhao; Doug R Braun; Spencer S Ericksen; Jeff S Piotrowski; Justin Nelson; Jian Peng; Gene E Ananiev; Shaurya Chanana; Kenneth Barns; Jen Fossen; Hiram Sanchez; Marc G Chevrette; Ilia A Guzei; Changgui Zhao; Le Guo; Weiping Tang; Cameron R Currie; Scott R Rajski; Anjon Audhya; David R Andes; Tim S Bugni
Journal:  Science       Date:  2020-11-20       Impact factor: 47.728

Review 4.  Polycyclic xanthone natural products: structure, biological activity and chemical synthesis.

Authors:  Dana K Winter; David L Sloman; John A Porco
Journal:  Nat Prod Rep       Date:  2013-01-21       Impact factor: 13.423

Review 5.  The Mechanistic Targets of Antifungal Agents: An Overview.

Authors:  Tryphon K Mazu; Barbara A Bricker; Hernan Flores-Rozas; Seth Y Ablordeppey
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

Review 6.  Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes.

Authors:  Hui-Qing Yu; Gang Li; Hong-Xiang Lou
Journal:  Front Microbiol       Date:  2022-07-13       Impact factor: 6.064

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.