OBJECTIVES: To determine whether shear wave elastography (SWE) would be useful in evaluating the presence of rejection or recurrent hepatitis for post-liver transplantation (LT) follow-up. METHODS: This retrospective study was approved by our Institutional Review Board and informed consent was waived. Two hundred sixteen liver recipients and 37 liver donors received SWE and concurrent liver biopsy. Of the liver recipients, 142 patients underwent SWE > 4 weeks after the LT (group 1) and 74 patients underwent SWE ≤ 4 weeks after the LT (group 2). Liver stiffness (LS) was compared among groups of donor, no rejection, acute rejection and recurrent hepatitis. RESULTS: In group 1, LS was higher in patients with rejection or hepatitis than in patients without rejection or indefinite rejection (12.29 ± 8.13 kPa vs. 6.33 ± 2.10 kPa, respectively, P < 0.001). In group 2, there was no difference in LS between patients with rejection (n = 8) and those without rejection (n = 61; P > 0.05). The liver recipients without rejection or hepatitis in both groups showed significantly higher LS than the liver donors (P < 0.001). CONCLUSIONS: SWE may be used as a non-invasive complementary tool to detect rejection or recurrent hepatitis at follow-up > 4 weeks after the LT. KEY POINTS: • Shear wave ultrasound elastography may be useful at follow-up after liver transplantation • Rejection or hepatitis can be predicted >4 weeks after liver transplantation • Normal liver grafts are stiffer than normal liver.
OBJECTIVES: To determine whether shear wave elastography (SWE) would be useful in evaluating the presence of rejection or recurrent hepatitis for post-liver transplantation (LT) follow-up. METHODS: This retrospective study was approved by our Institutional Review Board and informed consent was waived. Two hundred sixteen liver recipients and 37 liver donors received SWE and concurrent liver biopsy. Of the liver recipients, 142 patients underwent SWE > 4 weeks after the LT (group 1) and 74 patients underwent SWE ≤ 4 weeks after the LT (group 2). Liver stiffness (LS) was compared among groups of donor, no rejection, acute rejection and recurrent hepatitis. RESULTS: In group 1, LS was higher in patients with rejection or hepatitis than in patients without rejection or indefinite rejection (12.29 ± 8.13 kPa vs. 6.33 ± 2.10 kPa, respectively, P < 0.001). In group 2, there was no difference in LS between patients with rejection (n = 8) and those without rejection (n = 61; P > 0.05). The liver recipients without rejection or hepatitis in both groups showed significantly higher LS than the liver donors (P < 0.001). CONCLUSIONS: SWE may be used as a non-invasive complementary tool to detect rejection or recurrent hepatitis at follow-up > 4 weeks after the LT. KEY POINTS: • Shear wave ultrasound elastography may be useful at follow-up after liver transplantation • Rejection or hepatitis can be predicted >4 weeks after liver transplantation • Normal liver grafts are stiffer than normal liver.
Authors: Kausik Das; Rajib Sarkar; Sk Mahiuddin Ahmed; Asit R Mridha; Partha S Mukherjee; Kshaunish Das; Gopal K Dhali; Amal Santra; Abhijit Chowdhury Journal: Hepatology Date: 2011-12-29 Impact factor: 17.425
Authors: R Adam; M Reynes; M Johann; M Morino; I Astarcioglu; I Kafetzis; D Castaing; H Bismuth Journal: Transplant Proc Date: 1991-02 Impact factor: 1.066
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Authors: E J Gane; B C Portmann; N V Naoumov; H M Smith; J A Underhill; P T Donaldson; G Maertens; R Williams Journal: N Engl J Med Date: 1996-03-28 Impact factor: 91.245
Authors: Mickael Tanter; Jeremy Bercoff; Alexandra Athanasiou; Thomas Deffieux; Jean-Luc Gennisson; Gabriel Montaldo; Marie Muller; Anne Tardivon; Mathias Fink Journal: Ultrasound Med Biol Date: 2008-04-08 Impact factor: 2.998
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