Literature DB >> 23283670

Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products.

Anna L Vagstad1, Adam G Newman, Philip A Storm, Katherine Belecki, Jason M Crawford, Craig A Townsend.   

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Year:  2013        PMID： 23283670      PMCID： PMC3810244          DOI： 10.1002/anie.201208550

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  18 in total

1.  Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".

Authors:  Jason M Crawford; Anna L Vagstad; Karen P Whitworth; Kenneth C Ehrlich; Craig A Townsend
Journal:  Chembiochem       Date:  2008-05-05       Impact factor: 3.164

2.  Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi.

Authors:  Suzanne M Ma; Jixun Zhan; Kenji Watanabe; Xinkai Xie; Wenjun Zhang; Clay C Wang; Yi Tang
Journal:  J Am Chem Soc       Date:  2007-08-14       Impact factor: 15.419

3.  Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans.

Authors:  I Fujii; A Watanabe; U Sankawa; Y Ebizuka
Journal:  Chem Biol       Date:  2001-02

4.  Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.

Authors:  R S Gokhale; D Hunziker; D E Cane; C Khosla
Journal:  Chem Biol       Date:  1999-02

5.  Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.

Authors:  Jason M Crawford; Blair C R Dancy; Eric A Hill; Daniel W Udwary; Craig A Townsend
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-27       Impact factor: 11.205

6.  Pannorin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor produced by Chrysosporium pannorum.

Authors:  H Ogawa; K Hasumi; K Sakai; S Murakawa; A Endo
Journal:  J Antibiot (Tokyo)       Date:  1991-07       Impact factor: 2.649

7.  Deconstruction of iterative multidomain polyketide synthase function.

Authors:  Jason M Crawford; Paul M Thomas; Jonathan R Scheerer; Anna L Vagstad; Neil L Kelleher; Craig A Townsend
Journal:  Science       Date:  2008-04-11       Impact factor: 47.728

8.  Fungal type I polyketide synthases.

Authors:  Russell J Cox; Thomas J Simpson
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

9.  Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.

Authors:  Anna L Vagstad; Eric A Hill; Jason W Labonte; Craig A Townsend
Journal:  Chem Biol       Date:  2012-12-21

10.  The crystal structure of a mammalian fatty acid synthase.

Authors:  Timm Maier; Marc Leibundgut; Nenad Ban
Journal:  Science       Date:  2008-09-05       Impact factor: 47.728
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  21 in total

Review 1.  Emerging evolutionary paradigms in antibiotic discovery.

Authors:  Marc G Chevrette; Cameron R Currie
Journal:  J Ind Microbiol Biotechnol       Date:  2018-09-29       Impact factor: 3.346

Review 2.  The architectures of iterative type I PKS and FAS.

Authors:  Dominik A Herbst; Craig A Townsend; Timm Maier
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

3.  Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

Authors:  Maria L Adrover-Castellano; Jennifer J Schmidt; David H Sherman
Journal:  ChemCatChem       Date:  2021-01-28       Impact factor: 5.686

4.  Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.

Authors:  Yuquan Xu; Tong Zhou; Shuwei Zhang; Patricia Espinosa-Artiles; Luoyi Wang; Wei Zhang; Min Lin; A A Leslie Gunatilaka; Jixun Zhan; István Molnár
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-21       Impact factor: 11.205

5.  Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.

Authors:  Yuquan Xu; Tong Zhou; Shuwei Zhang; Li-Jiang Xuan; Jixun Zhan; István Molnár
Journal:  J Am Chem Soc       Date:  2013-07-12       Impact factor: 15.419

6.  Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA.

Authors:  Callie R Huitt-Roehl; Eric A Hill; Martina M Adams; Anna L Vagstad; Jesse W Li; Craig A Townsend
Journal:  ACS Chem Biol       Date:  2015-03-10       Impact factor: 5.100

7.  Exploring Fungal Polyketide C-Methylation through Combinatorial Domain Swaps.

Authors:  Philip A Storm; Paramita Pal; Callie R Huitt-Roehl; Craig A Townsend
Journal:  ACS Chem Biol       Date:  2018-10-30       Impact factor: 5.100

8.  Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase.

Authors:  Shu-Shan Gao; Abing Duan; Wei Xu; Peiyuan Yu; Leibniz Hang; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2016-03-22       Impact factor: 15.419

9.  Rational reprogramming of fungal polyketide first-ring cyclization.

Authors:  Yuquan Xu; Tong Zhou; Zhengfu Zhou; Shiyou Su; Sue A Roberts; William R Montfort; Jia Zeng; Ming Chen; Wei Zhang; Min Lin; Jixun Zhan; István Molnár
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-18       Impact factor: 11.205

10.  The structural organization of substrate loading in iterative polyketide synthases.

Authors:  Dominik A Herbst; Callie R Huitt-Roehl; Roman P Jakob; Jacob M Kravetz; Philip A Storm; Jamie R Alley; Craig A Townsend; Timm Maier
Journal:  Nat Chem Biol       Date:  2018-04-02       Impact factor: 15.040
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