BACKGROUND: Bony depressions at the wrist resembling erosions are frequently seen on MRI in healthy children. The accuracy of MRI in detecting early bony destruction is therefore questionable. We compared findings on MRI of the wrist in healthy children and those with juvenile idiopathic arthritis (JIA) to investigate markers for true disease. MATERIALS AND METHODS: We compared the number and localisation of bony depressions at the wrist in 85 healthy children and 68 children with JIA, ages 5-15 years. The size of the wrist was assessed from a radiograph of the wrist performed on the same day as the MRI. RESULTS: No significant difference in the number of bony depressions in the carpal bones was seen between healthy children and children with JIA at any age. Depressions are found in similar locations in the two groups, except for a few sites, where bony depressions were seen exclusively in the JIA group, particularly at the CMC joints. The wrist was significantly smaller in children with JIA (P < 0.001). CONCLUSIONS: Using adult scoring systems and standard MR sequences in the assessment of bone destruction in children may lead to overstaging or understaging of disease. At present, standard MRI sequences cannot easily be used for assessment of early signs of erosions in children.
BACKGROUND:Bony depressions at the wrist resembling erosions are frequently seen on MRI in healthy children. The accuracy of MRI in detecting early bony destruction is therefore questionable. We compared findings on MRI of the wrist in healthy children and those with juvenile idiopathic arthritis (JIA) to investigate markers for true disease. MATERIALS AND METHODS: We compared the number and localisation of bony depressions at the wrist in 85 healthy children and 68 children with JIA, ages 5-15 years. The size of the wrist was assessed from a radiograph of the wrist performed on the same day as the MRI. RESULTS: No significant difference in the number of bony depressions in the carpal bones was seen between healthy children and children with JIA at any age. Depressions are found in similar locations in the two groups, except for a few sites, where bony depressions were seen exclusively in the JIA group, particularly at the CMC joints. The wrist was significantly smaller in children with JIA (P < 0.001). CONCLUSIONS: Using adult scoring systems and standard MR sequences in the assessment of bone destruction in children may lead to overstaging or understaging of disease. At present, standard MRI sequences cannot easily be used for assessment of early signs of erosions in children.
Authors: Clara Malattia; Maria Beatrice Damasio; Angela Pistorio; Maka Ioseliani; Iris Vilca; Maura Valle; Nicolino Ruperto; Stefania Viola; Antonella Buoncompagni; Gian Michele Magnano; Angelo Ravelli; Paolo Tomà; Alberto Martini Journal: Ann Rheum Dis Date: 2010-11-24 Impact factor: 19.103
Authors: M Østergaard; J Edmonds; F McQueen; C Peterfy; M Lassere; B Ejbjerg; P Bird; P Emery; H Genant; P Conaghan Journal: Ann Rheum Dis Date: 2005-02 Impact factor: 19.103
Authors: Nicolino Ruperto; Daniel J Lovell; Ruben Cuttica; Nick Wilkinson; Patricia Woo; Graciela Espada; Carine Wouters; Earl D Silverman; Zsolt Balogh; Michael Henrickson; Maria-Teresa Apaz; Eileen Baildam; Anders Fasth; Valeria Gerloni; Pekka Lahdenne; Anne-Marie Prieur; Angelo Ravelli; Rotraud K Saurenmann; Maria Luz Gamir; Nico Wulffraat; Laszlo Marodi; Ross E Petty; Rik Joos; Francesco Zulian; Deborah McCurdy; Barry L Myones; Kalman Nagy; Peter Reuman; Ilona Szer; Suzanne Travers; Anna Beutler; Greg Keenan; Jason Clark; Sudha Visvanathan; Adedigbo Fasanmade; Aparna Raychaudhuri; Alan Mendelsohn; Alberto Martini; Edward H Giannini Journal: Arthritis Rheum Date: 2007-09
Authors: Anouk M Barendregt; E Charlotte van Gulik; Paul F C Groot; Koert M Dolman; J Merlijn van den Berg; Amara Nassar-Sheikh Rashid; Dieneke Schonenberg-Meinema; Cristina Lavini; Karen Rosendahl; Robert Hemke; Taco W Kuijpers; Mario Maas; Charlotte M Nusman Journal: Pediatr Radiol Date: 2019-02-01
Authors: Derk Frederik Matthaus Avenarius; Charlotte Nusman; Clara Malattia; Laura Tanturri de Horatio; Karen Rosendahl; Mario Maas; Lil-Sofie Ording Müller Journal: Pediatr Radiol Date: 2018-05-08