Peter Boavida1, Karen Lambot-Juhan2, Lil-Sofie Ording Müller3, Beatrice Damasio4, Laura Tanturri de Horatio5, Clara Malattia4, Catherine M Owens1,6, Karen Rosendahl7,8. 1. Department of Radiology, Great Ormond Street Hospital for Children, London, UK. 2. Department of Radiology, Hospital Necker Enfants Malades, Paris, France. 3. Department of Radiology, Oslo University Hospital, Oslo, Norway. 4. Department of Rheumatology, Ospedale Pediatrico Gaslini, Genoa, Italy. 5. Department of Radiology, Ospedale Pediatrico Bambino Gesu, Rome, Italy. 6. Institute of Child Health, UCL, London, UK. 7. Department of Radiology, Haukeland University Hospital, Jonas Lies vei 65, N-5021, Bergen, Norway. Karen.rosendahl@helse-bergen.no. 8. Department of Clinical Medicine, University of Bergen, Bergen, Norway. Karen.rosendahl@helse-bergen.no.
Abstract
BACKGROUND: Juvenile idiopathic arthritis (JIA) is characterized by synovial inflammation, with potential risk of developing progressive joint destruction. Personalized state-of-the-art treatment depends on valid markers for disease activity to monitor response; however, no such markers exist. OBJECTIVE: To evaluate the reliability of scoring of carpal bone erosions on MR in children with JIA using two semi-quantitative scoring systems. MATERIALS AND METHODS: A total of 1,236 carpal bones (91 MR wrist examinations) were scored twice by two independent pediatric musculoskeletal radiologists. Bony erosions were scored according to estimated bone volume loss using a 0-4 scale and a 0-10 scale. An aggregate erosion score comprising the sum total carpal bone volume loss was calculated for each examination. RESULTS: The 0-4 scoring system resulted in good intra-reader agreement and moderate to good inter-observer agreement in the assessment of individual bones. Fair and moderate agreement were achieved for inter-reader and intra-reader agreement, respectively, using the 0-10 scale. Intra- and particularly inter-reader aggregate score variability were much less favorable, with wide limits of agreement. CONCLUSION: Further analysis of erosive disease patterns compared with normal subjects is required, and to facilitate the development of an alternative means of quantifying disease.
BACKGROUND:Juvenile idiopathic arthritis (JIA) is characterized by synovial inflammation, with potential risk of developing progressive joint destruction. Personalized state-of-the-art treatment depends on valid markers for disease activity to monitor response; however, no such markers exist. OBJECTIVE: To evaluate the reliability of scoring of carpal bone erosions on MR in children with JIA using two semi-quantitative scoring systems. MATERIALS AND METHODS: A total of 1,236 carpal bones (91 MR wrist examinations) were scored twice by two independent pediatric musculoskeletal radiologists. Bony erosions were scored according to estimated bone volume loss using a 0-4 scale and a 0-10 scale. An aggregate erosion score comprising the sum total carpal bone volume loss was calculated for each examination. RESULTS: The 0-4 scoring system resulted in good intra-reader agreement and moderate to good inter-observer agreement in the assessment of individual bones. Fair and moderate agreement were achieved for inter-reader and intra-reader agreement, respectively, using the 0-10 scale. Intra- and particularly inter-reader aggregate score variability were much less favorable, with wide limits of agreement. CONCLUSION: Further analysis of erosive disease patterns compared with normal subjects is required, and to facilitate the development of an alternative means of quantifying disease.
Authors: Clara Malattia; Maria Beatrice Damasio; Angela Pistorio; Maka Ioseliani; Iris Vilca; Maura Valle; Nicolino Ruperto; Stefania Viola; Antonella Buoncompagni; Gian Michele Magnano; Angelo Ravelli; Paolo Tomà; Alberto Martini Journal: Ann Rheum Dis Date: 2010-11-24 Impact factor: 19.103
Authors: Clara Malattia; Maria B Damasio; Curzio Basso; Alessandro Verri; Francesca Magnaguagno; Stefania Viola; Marco Gattorno; Angelo Ravelli; Paolo Tomà; Alberto Martini Journal: Rheumatology (Oxford) Date: 2010-01 Impact factor: 7.580
Authors: Karen Lambot; Peter Boavida; Maria Beatrice Damasio; Laura Tanturri de Horatio; Marie Desgranges; Clara Malattia; Domenico Barbuti; Claudia Bracaglia; Lil-Sofie Ording Müller; Caroline Elie; Brigitte Bader-Meunier; Pierre Quartier; Karen Rosendahl; Francis Brunelle Journal: Pediatr Radiol Date: 2013-02-05
Authors: Marissa Lassere; Fiona McQueen; Mikkel Østergaard; Philip Conaghan; Ron Shnier; Charles Peterfy; Mette Klarlund; Paul Bird; Philip O'Connor; Neal Stewart; Paul Emery; Harry Genant; John Edmonds Journal: J Rheumatol Date: 2003-06 Impact factor: 4.666
Authors: Maria Beatrice Damasio; Clara Malattia; Laura Tanturri de Horatio; Chiara Mattiuz; Angela Pistorio; Claudia Bracaglia; Domenico Barbuti; Peter Boavida; Karen Lambot Juhan; Lil Sophie Mueller Ording; Karen Rosendahl; Alberto Martini; GianMichele Magnano; Paolo Tomà Journal: Pediatr Radiol Date: 2012-07-26
Authors: Jasper F M M Rieter; Laura Tanturri de Horatio; Charlotte M Nusman; Lil-Sofie Ording Müller; Robert Hemke; Derk F M Avenarius; Marion A J van Rossum; Clara Malattia; Mario Maas; Karen Rosendahl Journal: Pediatr Radiol Date: 2016-07-12
Authors: Derk Frederik Matthaus Avenarius; Charlotte Nusman; Clara Malattia; Laura Tanturri de Horatio; Karen Rosendahl; Mario Maas; Lil-Sofie Ording Müller Journal: Pediatr Radiol Date: 2018-05-08
Authors: Charlotte M Nusman; Laura Tanturri de Horatio; Robert Hemke; E Charlotte van Gulik; Lil-Sofie Ording Müller; Clara Malattia; Derk Avenarius; Paolo Toma; Johannes Roth; Nikolay Tzaribachev; Silvia Magni-Manzoni; Mario Maas; Andrea S Doria; Karen Rosendahl Journal: Pediatr Radiol Date: 2018-01-13