BACKGROUND: Cancer, by conferring a hypercoagulable state, may lead to an ischemic stroke. Relatively little is known about the prevalence and evolution of cancer among stroke patients over the last decade. METHODS: We used the Nationwide Inpatient Sample to identify discharges with any InternationalClassification of Diseases, Ninth Revision, diagnosis code for cancer and ischemic stroke from 1997 to 2006. We then calculated age-adjusted yearly acute ischemic stroke hospitalization rates among adult populations with and without cancer. RESULTS: Prevalence of cancer among hospitalized stroke patients increased from 1997 to 2006 (N = 31,075 [9.1% of all ischemic stroke hospitalizations] to 34,138 [10.6%], P < .0001). The most common types of cancer among hospitalized stroke patients in 1997 and 2006 were prostate (21% versus 19%), breast (19% versus 19%), gastrointestinal (16% versus 13%), and colorectal (13% versus 13%). Over the decade there was a significant decrease in the prevalence of stroke hospitalizations (slope -3.02, 95% confidence interval -3.69 to -2.34), but not among cancer patients (slope 1.35, 95% confidence interval -0.88 to 3.58). CONCLUSION: About 1 in 10 hospitalized ischemic stroke patients in the United States has comorbid cancer, and there has been a slight rise in this rate over the last decade. This is likely due to enhanced survival from better cancer treatments, but further study is warranted.
BACKGROUND:Cancer, by conferring a hypercoagulable state, may lead to an ischemic stroke. Relatively little is known about the prevalence and evolution of cancer among strokepatients over the last decade. METHODS: We used the Nationwide Inpatient Sample to identify discharges with any InternationalClassification of Diseases, Ninth Revision, diagnosis code for cancer and ischemic stroke from 1997 to 2006. We then calculated age-adjusted yearly acute ischemic stroke hospitalization rates among adult populations with and without cancer. RESULTS: Prevalence of cancer among hospitalized strokepatients increased from 1997 to 2006 (N = 31,075 [9.1% of all ischemic stroke hospitalizations] to 34,138 [10.6%], P < .0001). The most common types of cancer among hospitalized strokepatients in 1997 and 2006 were prostate (21% versus 19%), breast (19% versus 19%), gastrointestinal (16% versus 13%), and colorectal (13% versus 13%). Over the decade there was a significant decrease in the prevalence of stroke hospitalizations (slope -3.02, 95% confidence interval -3.69 to -2.34), but not among cancerpatients (slope 1.35, 95% confidence interval -0.88 to 3.58). CONCLUSION: About 1 in 10 hospitalized ischemic strokepatients in the United States has comorbid cancer, and there has been a slight rise in this rate over the last decade. This is likely due to enhanced survival from better cancer treatments, but further study is warranted.
Authors: Santosh B Murthy; Aditi Shastri; Alexander E Merkler; Daniel F Hanley; Wendy C Ziai; Matthew E Fink; Costantino Iadecola; Hooman Kamel; Babak B Navi Journal: J Stroke Cerebrovasc Dis Date: 2016-08-25 Impact factor: 2.136
Authors: Babak B Navi; Scott E Kasner; Mitchell S V Elkind; Mary Cushman; Oh Young Bang; Lisa M DeAngelis Journal: Stroke Date: 2021-01-28 Impact factor: 7.914
Authors: Babak B Navi; Carla P Sherman; Richard Genova; Ryna Mathias; Kelsey N Lansdale; Natalie M LeMoss; Julia Wolfe; Anna Skakodub; Hooman Kamel; Scott T Tagawa; Ashish Saxena; Allyson J Ocean; Gerald A Soff; Maria T DeSancho; Costantino Iadecola; Mitchell S V Elkind; Ellinor Peerschke; Cenai Zhang; Lisa M DeAngelis Journal: Ann Neurol Date: 2021-06-03 Impact factor: 11.274