Yajuan Chen1, Jinsheng Zeng2, Xingrui Xie1, Zijun Wang1, Xiaoting Wang1, Zhijian Liang1. 1. Department of Neurology, The First Affiliated Hospital of Guangxi Medical University Nanning City, Guangxi Province 530021, P. R. China. 2. Department of Neurology and Stroke Centre, The First Affiliated Hospital, Sun Yat-Sen University No. 58 Zhongshan Road 2, Guangzhou, 510080, P. R. China.
Abstract
BACKGROUND: The increased incidence of cerebral infarction in patients with systemic cancer has been reported; however, the underline mechanisms remain unclear. Investigation regarding the clinical features of cerebral infarction in cancer patients could be helpful to understand its underlying pathogenesis. METHODS: A total of 537 patients were recruited and divided into three groups: 1) stroke and cancer group (SCG), defined as active cancer patients with acute cerebral infarction; 2) stroke group (SG), defined as acute cerebral infarction patients without cancer; and 3) Cancer group (CG), defined as active cancer patients without cerebral infarction. These patients were age and gender-matched among groups. RESULTS: 179 patients, including 128 male subjects (73.68%) were enrolled in each group. Compared to SG patients, more SCG patients lacked conventional vascular risk factors (CRFs), and had elevated plasma D-dimer, cancer antigen (CA) 125 and 199 levels with multiple lesions in multiple cerebral arterial territories. In addition, SCG patients were found to have poorer prognosis. Compared to CG patients, more SCG patients' cancer had metastasized. Multiple logistic regression analysis showed that the elevated plasma D-dimer, CA125 and CA199 levels may independently increase, but chemoradiotherapy decreased the risk of cerebral infarction in cancer patients. CONCLUSIONS: Our study demonstrated that the clinical features of acute cerebral infarction in most active cancer patients can be identified as multiple lesions in multiple cerebral arterial territories with elevated plasma D-dimer and the elevated levels of cancer antigens.
BACKGROUND: The increased incidence of cerebral infarction in patients with systemic cancer has been reported; however, the underline mechanisms remain unclear. Investigation regarding the clinical features of cerebral infarction in cancerpatients could be helpful to understand its underlying pathogenesis. METHODS: A total of 537 patients were recruited and divided into three groups: 1) stroke and cancer group (SCG), defined as active cancerpatients with acute cerebral infarction; 2) stroke group (SG), defined as acute cerebral infarctionpatients without cancer; and 3) Cancer group (CG), defined as active cancerpatients without cerebral infarction. These patients were age and gender-matched among groups. RESULTS: 179 patients, including 128 male subjects (73.68%) were enrolled in each group. Compared to SG patients, more SCG patients lacked conventional vascular risk factors (CRFs), and had elevated plasma D-dimer, cancer antigen (CA) 125 and 199 levels with multiple lesions in multiple cerebral arterial territories. In addition, SCG patients were found to have poorer prognosis. Compared to CG patients, more SCG patients' cancer had metastasized. Multiple logistic regression analysis showed that the elevated plasma D-dimer, CA125 and CA199 levels may independently increase, but chemoradiotherapy decreased the risk of cerebral infarction in cancerpatients. CONCLUSIONS: Our study demonstrated that the clinical features of acute cerebral infarction in most active cancerpatients can be identified as multiple lesions in multiple cerebral arterial territories with elevated plasma D-dimer and the elevated levels of cancer antigens.
Authors: Paul L den Exter; Judith Kooiman; Tom van der Hulle; Menno V Huisman Journal: Best Pract Res Clin Haematol Date: 2013-07-20 Impact factor: 3.020
Authors: Oh Young Bang; Jin Myoung Seok; Seon Gyeong Kim; Ji Man Hong; Hahn Young Kim; Jun Lee; Pil-Wook Chung; Kwang-Yeol Park; Gyeong-Moon Kim; Chin-Sang Chung; Kwang Ho Lee Journal: J Clin Neurol Date: 2011-06-28 Impact factor: 3.077