| Literature DB >> 29633334 |
Babak B Navi1,2,3, Costantino Iadecola1,2.
Abstract
Currently 1 in 10 patients with ischemic stroke have comorbid cancer, and this frequency is expected to increase with continued advances in cancer therapeutics prolonging median survival. Well known for its association with venous thrombosis, cancer has recently emerged as a significant risk factor for arterial thromboembolism, including stroke; however, the underlying mechanisms are uncertain. In addition, the optimal strategies to prevent and acutely treat stroke in cancer patients are yet to be established. This review summarizes the current evidence on ischemic stroke risk, biomarkers, pathophysiology, treatments, and prognosis in cancer patients, emphasizing knowledge gaps and the potential strategies to address them. Ann Neurol 2018;83:873-883.Entities:
Mesh:
Year: 2018 PMID: 29633334 PMCID: PMC6021225 DOI: 10.1002/ana.25227
Source DB: PubMed Journal: Ann Neurol ISSN: 0364-5134 Impact factor: 10.422