| Literature DB >> 23202125 |
Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, John R Thompson, Erik Ingelsson, Danish Saleheen, Jeanette Erdmann, Benjamin A Goldstein, Kathleen Stirrups, Inke R König, Jean-Baptiste Cazier, Asa Johansson, Alistair S Hall, Jong-Young Lee, Cristen J Willer, John C Chambers, Tõnu Esko, Lasse Folkersen, Anuj Goel, Elin Grundberg, Aki S Havulinna, Weang K Ho, Jemma C Hopewell, Niclas Eriksson, Marcus E Kleber, Kati Kristiansson, Per Lundmark, Leo-Pekka Lyytikäinen, Suzanne Rafelt, Dmitry Shungin, Rona J Strawbridge, Gudmar Thorleifsson, Emmi Tikkanen, Natalie Van Zuydam, Benjamin F Voight, Lindsay L Waite, Weihua Zhang, Andreas Ziegler, Devin Absher, David Altshuler, Anthony J Balmforth, Inês Barroso, Peter S Braund, Christof Burgdorf, Simone Claudi-Boehm, David Cox, Maria Dimitriou, Ron Do, Alex S F Doney, NourEddine El Mokhtari, Per Eriksson, Krista Fischer, Pierre Fontanillas, Anders Franco-Cereceda, Bruna Gigante, Leif Groop, Stefan Gustafsson, Jörg Hager, Göran Hallmans, Bok-Ghee Han, Sarah E Hunt, Hyun M Kang, Thomas Illig, Thorsten Kessler, Joshua W Knowles, Genovefa Kolovou, Johanna Kuusisto, Claudia Langenberg, Cordelia Langford, Karin Leander, Marja-Liisa Lokki, Anders Lundmark, Mark I McCarthy, Christa Meisinger, Olle Melander, Evelin Mihailov, Seraya Maouche, Andrew D Morris, Martina Müller-Nurasyid, Kjell Nikus, John F Peden, N William Rayner, Asif Rasheed, Silke Rosinger, Diana Rubin, Moritz P Rumpf, Arne Schäfer, Mohan Sivananthan, Ci Song, Alexandre F R Stewart, Sian-Tsung Tan, Gudmundur Thorgeirsson, C Ellen van der Schoot, Peter J Wagner, George A Wells, Philipp S Wild, Tsun-Po Yang, Philippe Amouyel, Dominique Arveiler, Hanneke Basart, Michael Boehnke, Eric Boerwinkle, Paolo Brambilla, Francois Cambien, Adrienne L Cupples, Ulf de Faire, Abbas Dehghan, Patrick Diemert, Stephen E Epstein, Alun Evans, Marco M Ferrario, Jean Ferrières, Dominique Gauguier, Alan S Go, Alison H Goodall, Villi Gudnason, Stanley L Hazen, Hilma Holm, Carlos Iribarren, Yangsoo Jang, Mika Kähönen, Frank Kee, Hyo-Soo Kim, Norman Klopp, Wolfgang Koenig, Wolfgang Kratzer, Kari Kuulasmaa, Markku Laakso, Reijo Laaksonen, Ji-Young Lee, Lars Lind, Willem H Ouwehand, Sarah Parish, Jeong E Park, Nancy L Pedersen, Annette Peters, Thomas Quertermous, Daniel J Rader, Veikko Salomaa, Eric Schadt, Svati H Shah, Juha Sinisalo, Klaus Stark, Kari Stefansson, David-Alexandre Trégouët, Jarmo Virtamo, Lars Wallentin, Nicholas Wareham, Martina E Zimmermann, Markku S Nieminen, Christian Hengstenberg, Manjinder S Sandhu, Tomi Pastinen, Ann-Christine Syvänen, G Kees Hovingh, George Dedoussis, Paul W Franks, Terho Lehtimäki, Andres Metspalu, Pierre A Zalloua, Agneta Siegbahn, Stefan Schreiber, Samuli Ripatti, Stefan S Blankenberg, Markus Perola, Robert Clarke, Bernhard O Boehm, Christopher O'Donnell, Muredach P Reilly, Winfried März, Rory Collins, Sekar Kathiresan, Anders Hamsten, Jaspal S Kooner, Unnur Thorsteinsdottir, John Danesh, Colin N A Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert, Nilesh J Samani.
Abstract
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.Entities:
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Year: 2012 PMID： 23202125 PMCID： PMC3679547 DOI： 10.1038/ng.2480
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330