OBJECTIVE: Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single-nucleotide polymorphisms (SNPs). Because the frequency of CAD is increased among patients with rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs is increased in RA patients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD. METHODS: Coronary artery calcification (CAC) as detected by computed tomography was used as a measure of CAD in 561 patients with RA. One hundred SNPs associated with CAD in the general population were genotyped or imputed, and their relationship to CAC was established through multiple regression analysis for individual SNPs and a genetic risk score representing their cumulative effect. RESULTS: Ninety-one CAD-related SNPs were genotyped successfully; of these, 81 exhibited no association with CAC (Agatston units) or different CAC categorizations, either individually or collectively, in the genetic risk score. Only rs579459 (ABO) and rs17676451 (HAL) had a consistent positive association between genotype and CAC, with a significant increase in the frequency of the effect allele in both homozygous and heterozygous genotype distributions. Five were variably negatively associated. Furthermore, a positive association between the Disease Activity Score in 28 joints and CAC was observed, and after adjustment for traditional cardiovascular risk factors, it was not modified by correcting for the CAD-related SNP genetic risk score. CONCLUSION: The increased risk of CAC in patients with RA does not appear to operate primarily through established genetically regulated atherogenic mechanisms that are preponderant in the general population.
OBJECTIVE:Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single-nucleotide polymorphisms (SNPs). Because the frequency of CAD is increased among patients with rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs is increased in RApatients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD. METHODS:Coronary artery calcification (CAC) as detected by computed tomography was used as a measure of CAD in 561 patients with RA. One hundred SNPs associated with CAD in the general population were genotyped or imputed, and their relationship to CAC was established through multiple regression analysis for individual SNPs and a genetic risk score representing their cumulative effect. RESULTS: Ninety-one CAD-related SNPs were genotyped successfully; of these, 81 exhibited no association with CAC (Agatston units) or different CAC categorizations, either individually or collectively, in the genetic risk score. Only rs579459 (ABO) and rs17676451 (HAL) had a consistent positive association between genotype and CAC, with a significant increase in the frequency of the effect allele in both homozygous and heterozygous genotype distributions. Five were variably negatively associated. Furthermore, a positive association between the Disease Activity Score in 28 joints and CAC was observed, and after adjustment for traditional cardiovascular risk factors, it was not modified by correcting for the CAD-related SNP genetic risk score. CONCLUSION: The increased risk of CAC in patients with RA does not appear to operate primarily through established genetically regulated atherogenic mechanisms that are preponderant in the general population.
Authors: Philip Greenland; Robert O Bonow; Bruce H Brundage; Matthew J Budoff; Mark J Eisenberg; Scott M Grundy; Michael S Lauer; Wendy S Post; Paolo Raggi; Rita F Redberg; George P Rodgers; Leslee J Shaw; Allen J Taylor; William S Weintraub; Robert A Harrington; Jonathan Abrams; Jeffrey L Anderson; Eric R Bates; Cindy L Grines; Mark A Hlatky; Robert C Lichtenberg; Jonathan R Lindner; Gerald M Pohost; Richard S Schofield; Samuel J Shubrooks; James H Stein; Cynthia M Tracy; Robert A Vogel; Deborah J Wesley Journal: Circulation Date: 2007-01-12 Impact factor: 29.690
Authors: J Jeffrey Carr; Jennifer Clark Nelson; Nathan D Wong; Michael McNitt-Gray; Yadon Arad; David R Jacobs; Stephan Sidney; Diane E Bild; O Dale Williams; Robert C Detrano Journal: Radiology Date: 2005-01 Impact factor: 11.105
Authors: Jessica van Setten; Ivana Išgum; Sonali Pechlivanis; Vinicius Tragante; Pim A de Jong; Joanna Smolonska; Mathieu Platteel; Per Hoffmann; Matthijs Oudkerk; Harry J de Koning; Markus M Nöthen; Susanne Moebus; Raimund Erbel; Karl-Heinz Jöckel; Max A Viergever; Willem P Th M Mali; Paul I W de Bakker Journal: Circ Cardiovasc Genet Date: 2015-01-10
Authors: Benjamin F Voight; Hyun Min Kang; Jun Ding; Cameron D Palmer; Carlo Sidore; Peter S Chines; Noël P Burtt; Christian Fuchsberger; Yanming Li; Jeanette Erdmann; Timothy M Frayling; Iris M Heid; Anne U Jackson; Toby Johnson; Tuomas O Kilpeläinen; Cecilia M Lindgren; Andrew P Morris; Inga Prokopenko; Joshua C Randall; Richa Saxena; Nicole Soranzo; Elizabeth K Speliotes; Tanya M Teslovich; Eleanor Wheeler; Jared Maguire; Melissa Parkin; Simon Potter; N William Rayner; Neil Robertson; Kathleen Stirrups; Wendy Winckler; Serena Sanna; Antonella Mulas; Ramaiah Nagaraja; Francesco Cucca; Inês Barroso; Panos Deloukas; Ruth J F Loos; Sekar Kathiresan; Patricia B Munroe; Christopher Newton-Cheh; Arne Pfeufer; Nilesh J Samani; Heribert Schunkert; Joel N Hirschhorn; David Altshuler; Mark I McCarthy; Gonçalo R Abecasis; Michael Boehnke Journal: PLoS Genet Date: 2012-08-02 Impact factor: 5.917
Authors: Jon T Giles; Moyses Szklo; Wendy Post; Michelle Petri; Roger S Blumenthal; Gordon Lam; Allan C Gelber; Robert Detrano; William W Scott; Richard A Kronmal; Joan M Bathon Journal: Arthritis Res Ther Date: 2009-03-10 Impact factor: 5.156
Authors: Bogdan Batko; Karol Urbański; Jerzy Świerkot; Piotr Wiland; Filip Raciborski; Mariusz Jędrzejewski; Mateusz Koziej; Marta Cześnikiewicz-Guzik; Tomasz J Guzik; Marcin Stajszczyk Journal: Clin Rheumatol Date: 2019-05-10 Impact factor: 2.980
Authors: Bartłomiej Kisiel; Robert Kruszewski; Aleksandra Juszkiewicz; Anna Raczkiewicz; Artur Bachta; Krzysztof Kłos; Krzysztof Duda; Artur Maliborski; Konrad Szymański; Rafał Płoski; Marek Saracyn; Stanisław Niemczyk; Katarzyna Kisiel; Małgorzata Tłustochowicz; Witold Tłustochowicz Journal: Rheumatol Int Date: 2018-10-29 Impact factor: 2.631
Authors: Raquel López-Mejías; Alfonso Corrales; Esther Vicente; Montserrat Robustillo-Villarino; Carlos González-Juanatey; Javier Llorca; Fernanda Genre; Sara Remuzgo-Martínez; Trinidad Dierssen-Sotos; José A Miranda-Filloy; Marco A Ramírez Huaranga; Trinitario Pina; Ricardo Blanco; Juan J Alegre-Sancho; Enrique Raya; Verónica Mijares; Begoña Ubilla; Iván Ferraz-Amaro; Carmen Gómez-Vaquero; Alejandro Balsa; Francisco J López-Longo; Patricia Carreira; Isidoro González-Álvaro; J Gonzalo Ocejo-Vinyals; Luis Rodríguez-Rodríguez; Benjamín Fernández-Gutiérrez; Santos Castañeda; Javier Martín; Miguel A González-Gay Journal: Sci Rep Date: 2017-01-06 Impact factor: 4.379