Literature DB >> 19198612

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

Jeanette Erdmann1, Anika Grosshennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K Wagner, Klaus Stark, Stephen M Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F Voight, Christopher J O'Donnell, Leena Peltonen, David S Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G Ball, Anthony J Balmforth, H-Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H Ouwehand, Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert.   

Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

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Year:  2009        PMID： 19198612      PMCID： PMC2695543          DOI： 10.1038/ng.307

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

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2.  A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Authors:  Anna Helgadottir; Gudmar Thorleifsson; Andrei Manolescu; Solveig Gretarsdottir; Thorarinn Blondal; Aslaug Jonasdottir; Adalbjorg Jonasdottir; Asgeir Sigurdsson; Adam Baker; Arnar Palsson; Gisli Masson; Daniel F Gudbjartsson; Kristinn P Magnusson; Karl Andersen; Allan I Levey; Valgerdur M Backman; Sigurborg Matthiasdottir; Thorbjorg Jonsdottir; Stefan Palsson; Helga Einarsdottir; Steinunn Gunnarsdottir; Arnaldur Gylfason; Viola Vaccarino; W Craig Hooper; Muredach P Reilly; Christopher B Granger; Harland Austin; Daniel J Rader; Svati H Shah; Arshed A Quyyumi; Jeffrey R Gulcher; Gudmundur Thorgeirsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Science       Date:  2007-05-03       Impact factor: 47.728

3.  No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.

Authors: 
Journal:  Circulation       Date:  2003-03-04       Impact factor: 29.690

4.  A common allele on chromosome 9 associated with coronary heart disease.

Authors:  Ruth McPherson; Alexander Pertsemlidis; Nihan Kavaslar; Alexandre Stewart; Robert Roberts; David R Cox; David A Hinds; Len A Pennacchio; Anne Tybjaerg-Hansen; Aaron R Folsom; Eric Boerwinkle; Helen H Hobbs; Jonathan C Cohen
Journal:  Science       Date:  2007-05-03       Impact factor: 47.728

5.  The fine-scale structure of recombination rate variation in the human genome.

Authors:  Gilean A T McVean; Simon R Myers; Sarah Hunt; Panos Deloukas; David R Bentley; Peter Donnelly
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6.  Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.

Authors:  Heribert Schunkert; Anika Götz; Peter Braund; Ralph McGinnis; David-Alexandre Tregouet; Massimo Mangino; Patrick Linsel-Nitschke; Francois Cambien; Christian Hengstenberg; Klaus Stark; Stefan Blankenberg; Laurence Tiret; Pierre Ducimetiere; Andrew Keniry; Mohammed J R Ghori; Stefan Schreiber; Nour Eddine El Mokhtari; Alistair S Hall; Richard J Dixon; Alison H Goodall; Henrike Liptau; Helen Pollard; Daniel F Schwarz; Ludwig A Hothorn; H-Erich Wichmann; Inke R König; Marcus Fischer; Christa Meisinger; Willem Ouwehand; Panos Deloukas; John R Thompson; Jeanette Erdmann; Andreas Ziegler; Nilesh J Samani
Journal:  Circulation       Date:  2008-03-24       Impact factor: 29.690

7.  Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.

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8.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
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9.  Genomewide association analysis of coronary artery disease.

Authors:  Nilesh J Samani; Jeanette Erdmann; Alistair S Hall; Christian Hengstenberg; Massimo Mangino; Bjoern Mayer; Richard J Dixon; Thomas Meitinger; Peter Braund; H-Erich Wichmann; Jennifer H Barrett; Inke R König; Suzanne E Stevens; Silke Szymczak; David-Alexandre Tregouet; Mark M Iles; Friedrich Pahlke; Helen Pollard; Wolfgang Lieb; Francois Cambien; Marcus Fischer; Willem Ouwehand; Stefan Blankenberg; Anthony J Balmforth; Andrea Baessler; Stephen G Ball; Tim M Strom; Ingrid Braenne; Christian Gieger; Panos Deloukas; Martin D Tobin; Andreas Ziegler; John R Thompson; Heribert Schunkert
Journal:  N Engl J Med       Date:  2007-07-18       Impact factor: 91.245

10.  Common variants at 30 loci contribute to polygenic dyslipidemia.

Authors:  Sekar Kathiresan; Cristen J Willer; Gina M Peloso; Serkalem Demissie; Kiran Musunuru; Eric E Schadt; Lee Kaplan; Derrick Bennett; Yun Li; Toshiko Tanaka; Benjamin F Voight; Lori L Bonnycastle; Anne U Jackson; Gabriel Crawford; Aarti Surti; Candace Guiducci; Noel P Burtt; Sarah Parish; Robert Clarke; Diana Zelenika; Kari A Kubalanza; Mario A Morken; Laura J Scott; Heather M Stringham; Pilar Galan; Amy J Swift; Johanna Kuusisto; Richard N Bergman; Jouko Sundvall; Markku Laakso; Luigi Ferrucci; Paul Scheet; Serena Sanna; Manuela Uda; Qiong Yang; Kathryn L Lunetta; Josée Dupuis; Paul I W de Bakker; Christopher J O'Donnell; John C Chambers; Jaspal S Kooner; Serge Hercberg; Pierre Meneton; Edward G Lakatta; Angelo Scuteri; David Schlessinger; Jaakko Tuomilehto; Francis S Collins; Leif Groop; David Altshuler; Rory Collins; G Mark Lathrop; Olle Melander; Veikko Salomaa; Leena Peltonen; Marju Orho-Melander; Jose M Ordovas; Michael Boehnke; Gonçalo R Abecasis; Karen L Mohlke; L Adrienne Cupples
Journal:  Nat Genet       Date:  2008-12-07       Impact factor: 38.330
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  201 in total

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Journal:  Circ Cardiovasc Genet       Date:  2010-10-05

2.  Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

Authors:  Christopher J O'Donnell; Maryam Kavousi; Albert V Smith; Sharon L R Kardia; Mary F Feitosa; Shih-Jen Hwang; Yan V Sun; Michael A Province; Thor Aspelund; Abbas Dehghan; Udo Hoffmann; Lawrence F Bielak; Qunyuan Zhang; Gudny Eiriksdottir; Cornelia M van Duijn; Caroline S Fox; Mariza de Andrade; Aldi T Kraja; Sigurdur Sigurdsson; Suzette E Elias-Smale; Joanne M Murabito; Lenore J Launer; Aad van der Lugt; Sekar Kathiresan; Gabriel P Krestin; David M Herrington; Timothy D Howard; Yongmei Liu; Wendy Post; Braxton D Mitchell; Jeffrey R O'Connell; Haiqing Shen; Alan R Shuldiner; David Altshuler; Roberto Elosua; Veikko Salomaa; Stephen M Schwartz; David S Siscovick; Benjamin F Voight; Joshua C Bis; Nicole L Glazer; Bruce M Psaty; Eric Boerwinkle; Gerardo Heiss; Stefan Blankenberg; Tanja Zeller; Philipp S Wild; Renate B Schnabel; Arne Schillert; Andreas Ziegler; Thomas F Münzel; Charles C White; Jerome I Rotter; Michael Nalls; Matthijs Oudkerk; Andrew D Johnson; Anne B Newman; Andre G Uitterlinden; Joseph M Massaro; Julie Cunningham; Tamara B Harris; Albert Hofman; Patricia A Peyser; Ingrid B Borecki; L Adrienne Cupples; Vilmundur Gudnason; Jacqueline C M Witteman
Journal:  Circulation       Date:  2011-12-05       Impact factor: 29.690

3.  Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.

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4.  Cohort Profile: the international childhood cardiovascular cohort (i3C) consortium.

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Journal:  Int J Epidemiol       Date:  2012-03-20       Impact factor: 7.196

Review 5.  Emerging clinical applications in cardiovascular pharmacogenomics.

Authors:  Samir B Damani; Eric J Topol
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6.  The 'Whole Genome Age'

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7.  Role of genomics in cardiovascular medicine.

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Journal:  World J Cardiol       Date:  2010-12-26

8.  Identifying disease polymorphisms from case-control genetic association data.

Authors:  L Park
Journal:  Genetica       Date:  2010-10-14       Impact factor: 1.082

9.  Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies.

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Journal:  Circ Cardiovasc Genet       Date:  2010-08-21

Review 10.  Genetic causes of myocardial infarction: new insights from genome-wide association studies.

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