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Literature DB >> 2319654

A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli.

O Faktor¹, S Budlovsky, R Ben-Levy, Y Shaul.

Abstract

The hepatitis B virus enhancer can be dissected into multiple functional elements, one of which is the E element. We show here that the E element binds multiple nuclear proteins that are essential for its enhancer activity. These findings, together with the ability of this element to respond to at least two different viral transactivators, suggest that the E element is an enhancer modulator capable of binding different factors and responding to multiple stimuli.

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Year: 1990 PMID： 2319654 PMCID： PMC249331

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

13 in total

Review 1. The molecular biology of the hepatitis B viruses.

Authors: D Ganem; H E Varmus
Journal: Annu Rev Biochem Date: 1987 Impact factor: 23.643

Review 2. Fos and Jun: the AP-1 connection.

Authors: T Curran; B R Franza
Journal: Cell Date: 1988-11-04 Impact factor: 41.582

3. The SV40 enhancer contains two distinct levels of organization.

Authors: B Ondek; L Gloss; W Herr
Journal: Nature Date: 1988-05-05 Impact factor: 49.962

4. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

Authors: P Angel; M Imagawa; R Chiu; B Stein; R J Imbra; H J Rahmsdorf; C Jonat; P Herrlich; M Karin
Journal: Cell Date: 1987-06-19 Impact factor: 41.582

5. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.

Authors: W Lee; P Mitchell; R Tjian
Journal: Cell Date: 1987-06-19 Impact factor: 41.582

6. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.

Authors: M R Montminy; L M Bilezikjian
Journal: Nature Date: 1987 Jul 9-15 Impact factor: 49.962

7. A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

Authors: R H Costa; D R Grayson; K G Xanthopoulos; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1988-06 Impact factor: 11.205

8. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

Authors: E H Birkenmeier; B Gwynn; S Howard; J Jerry; J I Gordon; W H Landschulz; S L McKnight
Journal: Genes Dev Date: 1989-08 Impact factor: 11.361

9. A human hepatitis B viral enhancer element.

Authors: Y Shaul; W J Rutter; O Laub
Journal: EMBO J Date: 1985-02 Impact factor: 11.598

10. Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

Authors: Y Shaul; R Ben-Levy
Journal: EMBO J Date: 1987-07 Impact factor: 11.598

19 in total

1. Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.

Authors: S Barnabas; O M Andrisani
Journal: J Virol Date: 2000-01 Impact factor: 5.103

A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli.

Review 1. The molecular biology of the hepatitis B viruses.

Review 2. Fos and Jun: the AP-1 connection.

3. The SV40 enhancer contains two distinct levels of organization.

4. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

5. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.

6. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.

7. A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

8. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

9. A human hepatitis B viral enhancer element.

10. Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

1. Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.

2. Mutational analysis of enhancer domains responsive to trans-activation by the X gene of human hepatitis B virus.

3. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.

4. Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

5. Functional organization of the hepatitis B virus enhancer.

6. In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.

7. A transcription initiation site for the hepatitis B virus X gene is directed by the promoter-binding protein.

8. The X protein of hepatitis B virus coactivates potent activation domains.

9. TIP60 Complex Inhibits Hepatitis B Virus Transcription.

10. Functional analysis of a liver-specific enhancer of the hepatitis B virus.