Literature DB >> 2370872

Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

R Dikstein1, O Faktor, Y Shaul.   

Abstract

We used the enhancer-binding protein C/EBP as a model to study the nature and the complexity of interaction of an enhancer-binding protein with its target DNA. We found that bacterially expressed C/EBP binds the hepatitis B virus enhancer at multiple sites in a hierarchic and cooperative manner. At low concentrations, only the E element is occupied, but at higher concentrations, additional sites are filled including a site that binds EP, a crucial enhancer-activating protein. This pattern of C/EBP binding may explain the concentration-dependent effect of C/EBP on enhancer activity.

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Year:  1990        PMID： 2370872      PMCID： PMC361010          DOI： 10.1128/mcb.10.8.4427-4430.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  16 in total

1.  Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

Authors:  P F Johnson; W H Landschulz; B J Graves; S L McKnight
Journal:  Genes Dev       Date:  1987-04       Impact factor: 11.361

2.  A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

Authors:  H Singh; R Sen; D Baltimore; P A Sharp
Journal:  Nature       Date:  1986 Jan 9-15       Impact factor: 49.962

3.  A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli.

Authors:  O Faktor; S Budlovsky; R Ben-Levy; Y Shaul
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

4.  Functional organization of the hepatitis B virus enhancer.

Authors:  R Dikstein; O Faktor; R Ben-Levy; Y Shaul
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

5.  Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer.

Authors:  J Honigwachs; O Faktor; R Dikstein; Y Shaul; O Laub
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

6.  Isolation of a recombinant copy of the gene encoding C/EBP.

Authors:  W H Landschulz; P F Johnson; E Y Adashi; B J Graves; S L McKnight
Journal:  Genes Dev       Date:  1988-07       Impact factor: 11.361

7.  The human hepatitis B virus enhancer requires trans-acting cellular factor(s) for activity.

Authors:  S Jameel; A Siddiqui
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

8.  Identification of a promoter element located upstream from the hepatitis B virus X gene.

Authors:  M Treinin; O Laub
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

9.  A human hepatitis B viral enhancer element.

Authors:  Y Shaul; W J Rutter; O Laub
Journal:  EMBO J       Date:  1985-02       Impact factor: 11.598

10.  Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

Authors:  Y Shaul; R Ben-Levy
Journal:  EMBO J       Date:  1987-07       Impact factor: 11.598
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  18 in total

1.  CAAT/enhancer binding protein is able to bind to ATF/CRE elements.

Authors:  O Bakker; M G Parker
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971

2.  Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.

Authors:  M Zajac-Kaye; N Ben-Baruch; E Kastanos; F J Kaye; C Allegra
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

3.  Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.

Authors:  P N Gilles; G Fey; F V Chisari
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

4.  TIP60 Complex Inhibits Hepatitis B Virus Transcription.

Authors:  Hironori Nishitsuji; Saneyuki Ujino; Keisuke Harada; Kunitada Shimotohno
Journal:  J Virol       Date:  2018-02-26       Impact factor: 5.103

5.  Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor.

Authors:  A K Raney; H B Le; A McLachlan
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

6.  Functional analysis of a liver-specific enhancer of the hepatitis B virus.

Authors:  M A Trujillo; J Letovsky; H F Maguire; M Lopez-Cabrera; A Siddiqui
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

7.  Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleocapsid promoter.

Authors:  P Zhang; A K Raney; A McLachlan
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

8.  Transcriptional and posttranscriptional control of hepatitis B virus gene expression.

Authors:  Susan L Uprichard; Stefan F Wieland; Alana Althage; Francis V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-27       Impact factor: 11.205

9.  The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes.

Authors:  W Reinhold; L Emens; A Itkes; M Blake; I Ichinose; M Zajac-Kaye
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

10.  Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.

Authors:  A D Garcia; P Ostapchuk; P Hearing
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103
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