Literature DB >> 23192436

Acute upper gastrointestinal bleeding in the elderly: aetiology, diagnosis and treatment.

Asma Ahmed1, Adrian J Stanley.   

Abstract

Acute upper gastrointestinal bleeding (UGIB) is a common, potentially life threatening medical emergency. It is associated with higher rates of hospitalization, morbidity and mortality in the elderly when compared with younger patients, most likely due to higher prevalence of multiple comorbidities. Age is an independent risk factor for mortality in UGIB, with Helicobacter pylori infection and the use of non-steroidal anti-inflammatory agents and anticoagulants being the most prevalent causal risk factors. These patients require early risk assessment, resuscitation and an attempt to identify and treat the bleeding source. In the majority, this involves early endoscopy and endotherapy as required to achieve haemostasis, with radiological intervention or surgery needed in the minority with ongoing severe bleeding. In this article, we discuss UGIB in the elderly, focusing on aetiology, risk factors and management.

Entities:  

Mesh:

Year:  2012        PMID: 23192436     DOI: 10.1007/s40266-012-0020-5

Source DB:  PubMed          Journal:  Drugs Aging        ISSN: 1170-229X            Impact factor:   3.923


  46 in total

1.  Anemia and ischemia: myocardial injury in patients with gastrointestinal bleeding.

Authors:  Fabio Bellotto; Stefano Fagiuoli; Andrea Pavei; Shawn A Gregory; Arianna Cati; Elisabetta Silverj; Mario Plebani; Martina Zaninotto; Tommaso Mancuso; Sabino Iliceto
Journal:  Am J Med       Date:  2005-05       Impact factor: 4.965

2.  Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.

Authors:  Kam-Chuen Lai; Kent-Man Chu; Wai-Mo Hui; Benjamin Chun-Yu Wong; Wai-Ka Hung; Ching-Kong Loo; Wayne Hsing-Ching Hu; Annie On-On Chan; Ka-Fai Kwok; Tang-Tat Fung; John Wong; Shiu-Kum Lam
Journal:  Clin Gastroenterol Hepatol       Date:  2006-06-22       Impact factor: 11.382

3.  Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis.

Authors:  Jia Qing Huang; Subbaramiah Sridhar; Richard H Hunt
Journal:  Lancet       Date:  2002-01-05       Impact factor: 79.321

4.  Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.

Authors:  Francis K L Chan; Jessica Y L Ching; Lawrence C T Hung; Vincent W S Wong; Vincent K S Leung; Nelson N S Kung; Aric J Hui; Justin C Y Wu; Wai K Leung; Vivian W Y Lee; Kenneth K C Lee; Yuk T Lee; James Y W Lau; Ka F To; Henry L Y Chan; S C Sydney Chung; Joseph J Y Sung
Journal:  N Engl J Med       Date:  2005-01-20       Impact factor: 91.245

5.  Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.

Authors:  J Y Lau; J J Sung; K K Lee; M Y Yung; S K Wong; J C Wu; F K Chan; E K Ng; J H You; C W Lee; A C Chan; S C Chung
Journal:  N Engl J Med       Date:  2000-08-03       Impact factor: 91.245

6.  Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis.

Authors:  Angel Lanas; Ping Wu; Jennie Medin; Edward J Mills
Journal:  Clin Gastroenterol Hepatol       Date:  2011-06-06       Impact factor: 11.382

Review 7.  Systematic review: the presenting international normalised ratio (INR) as a predictor of outcome in patients with upper nonvariceal gastrointestinal bleeding.

Authors:  A Shingina; A N Barkun; A Razzaghi; M Martel; M Bardou; I Gralnek
Journal:  Aliment Pharmacol Ther       Date:  2011-03-08       Impact factor: 8.171

8.  International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding.

Authors:  Alan N Barkun; Marc Bardou; Ernst J Kuipers; Joseph Sung; Richard H Hunt; Myriam Martel; Paul Sinclair
Journal:  Ann Intern Med       Date:  2010-01-19       Impact factor: 25.391

9.  Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation.

Authors:  A J Stanley; D Ashley; H R Dalton; C Mowat; D R Gaya; E Thompson; U Warshow; M Groome; A Cahill; G Benson; O Blatchford; W Murray
Journal:  Lancet       Date:  2008-12-16       Impact factor: 79.321

10.  Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases.

Authors:  Joseph J Y Sung; Kelvin K F Tsoi; Terry K W Ma; Man-Yee Yung; James Y W Lau; Philip W Y Chiu
Journal:  Am J Gastroenterol       Date:  2009-09-15       Impact factor: 10.864

View more
  7 in total

1.  Resuming Anticoagulation Following Hospitalization for Gastrointestinal Bleeding Is Associated with Reduced Thromboembolic Events and Improved Mortality: Results from a Systematic Review and Meta-Analysis.

Authors:  Natalie Tapaskar; Alice Pang; Debra A Werner; Neil Sengupta
Journal:  Dig Dis Sci       Date:  2020-04-11       Impact factor: 3.199

Review 2.  Increased susceptibility of aging gastric mucosa to injury: the mechanisms and clinical implications.

Authors:  Andrzej S Tarnawski; Amrita Ahluwalia; Michael K Jones
Journal:  World J Gastroenterol       Date:  2014-04-28       Impact factor: 5.742

Review 3.  Role of interventional radiology in the management of acute gastrointestinal bleeding.

Authors:  Raja S Ramaswamy; Hyung Won Choi; Hans C Mouser; Kazim H Narsinh; Kevin C McCammack; Tharintorn Treesit; Thomas B Kinney
Journal:  World J Radiol       Date:  2014-04-28

4.  Is tramadol associated to bleeding peptic ulcer? A nationwide case-control study in hospitalized Swedish patients.

Authors:  Hans Järnbert-Pettersson; Marine L Andersson; Katarina Bilén; Olle Broström; Jonatan D Lindh; Buster Mannheimer
Journal:  PLoS One       Date:  2019-04-17       Impact factor: 3.240

5.  Older age and diclofenac are associated with increased risk of upper gastrointestinal bleeding in gout patients.

Authors:  Wan Syamimee Wan Ghazali; Wan Mohd Khairul Bin Wan Zainudin; Nurul Khaiza Yahya; Asmahan Mohamed Ismail; Kah Keng Wong
Journal:  PeerJ       Date:  2021-05-20       Impact factor: 2.984

6.  Factors Associated with Outcome in Patients with Acute Upper Gastrointestinal Bleeding in a Tertiary Referral Center in Northern Iran.

Authors:  Fatemeh Baradaran; Alireza Norouzi; Samaneh Tavassoli; Abdolvahab Baradaran; Gholamreza Roshandel
Journal:  Middle East J Dig Dis       Date:  2016-07

7.  Do NSAIDs and ASA Cause More Upper Gastrointestinal Bleeding in Elderly than Adults?

Authors:  Hakan Kocoglu; Basak Oguz; Hakan Dogan; Yildiz Okuturlar; Mehmet Hursitoglu; Ozlem Harmankaya; Yuksel Altuntas; Abdulbaki Kumbasar
Journal:  Gastroenterol Res Pract       Date:  2016-01-05       Impact factor: 2.260

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.