Literature DB >> 23180511

A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target.

Peter Faller1, Christelle Hureau.   

Abstract

Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer's disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23180511     DOI： 10.1002/chem.201202697

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  21 in total

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Authors:  Jessica Nasica-Labouze; Phuong H Nguyen; Fabio Sterpone; Olivia Berthoumieu; Nicolae-Viorel Buchete; Sébastien Coté; Alfonso De Simone; Andrew J Doig; Peter Faller; Angel Garcia; Alessandro Laio; Mai Suan Li; Simone Melchionna; Normand Mousseau; Yuguang Mu; Anant Paravastu; Samuela Pasquali; David J Rosenman; Birgit Strodel; Bogdan Tarus; John H Viles; Tong Zhang; Chunyu Wang; Philippe Derreumaux
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2.  L-edge spectroscopy of dilute, radiation-sensitive systems using a transition-edge-sensor array.

Authors:  Charles J Titus; Michael L Baker; Sang Jun Lee; Hsiao-Mei Cho; William B Doriese; Joseph W Fowler; Kelly Gaffney; Johnathon D Gard; Gene C Hilton; Chris Kenney; Jason Knight; Dale Li; Ronald Marks; Michael P Minitti; Kelsey M Morgan; Galen C O'Neil; Carl D Reintsema; Daniel R Schmidt; Dimosthenis Sokaras; Daniel S Swetz; Joel N Ullom; Tsu-Chien Weng; Christopher Williams; Betty A Young; Kent D Irwin; Edward I Solomon; Dennis Nordlund
Journal:  J Chem Phys       Date:  2017-12-07       Impact factor: 3.488

3.  Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species.

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Journal:  Chem Sci       Date:  2014-12-01       Impact factor: 9.825

4.  Aroylhydrazones constitute a promising class of 'metal-protein attenuating compounds' for the treatment of Alzheimer's disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone.

Authors:  Daphne S Cukierman; Elio Accardo; Rosana Garrido Gomes; Anna De Falco; Marco C Miotto; Maria Clara Ramalho Freitas; Mauricio Lanznaster; Claudio O Fernández; Nicolás A Rey
Journal:  J Biol Inorg Chem       Date:  2018-08-25       Impact factor: 3.358

5.  A Peroxynitrite Dicopper Complex: Formation via Cu-NO and Cu-O2 Intermediates and Reactivity via O-O Cleavage Chemistry.

Authors:  Rui Cao; Lee Taylor Elrod; Ryan L Lehane; Eunsuk Kim; Kenneth D Karlin
Journal:  J Am Chem Soc       Date:  2016-12-02       Impact factor: 15.419

6.  Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

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Journal:  ChemMedChem       Date:  2017-10-09       Impact factor: 3.466

7.  N4 -Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β1-16.

Authors:  Weixin Zhang; Yan Liu; Christelle Hureau; Anne Robert; Bernard Meunier
Journal:  Chemistry       Date:  2018-05-15       Impact factor: 5.236

8.  A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.

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Journal:  Chemistry       Date:  2017-11-09       Impact factor: 5.236

9.  Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.

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Journal:  Sci Rep       Date:  2015-09-09       Impact factor: 4.379

10.  Acute intracerebral treatment with amyloid-beta (1-42) alters the profile of neuronal oscillations that accompany LTP induction and results in impaired LTP in freely behaving rats.

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