Literature DB >> 23175586

Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters.

Kyle M Whitten1, Alexandros Makriyannis, Subramanian K Vadivel.   

Abstract

Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2-24 hrs with yields ranging from 41-98%.

Entities:  

Year:  2012        PMID： 23175586      PMCID： PMC3500964          DOI： 10.1016/j.tetlet.2012.08.042

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  16 in total

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Review 6.  Fatty acid amide signaling molecules.

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8.  Enzymatic synthesis of C-terminal arylamides of amino acids and peptides.

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Journal:  J Org Chem       Date:  2009-08-07       Impact factor: 4.354

9.  (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.

Authors:  V Abadji; S Lin; G Taha; G Griffin; L A Stevenson; R G Pertwee; A Makriyannis
Journal:  J Med Chem       Date:  1994-06-10       Impact factor: 7.446

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Journal:  Molecules       Date:  2022-06-04       Impact factor: 4.927

2.  Effect of the acyl-group length on the chemoselectivity of the lipase-catalyzed acylation of propranolol-a computational study.

Authors:  Markus Doerr; Alexander Romero; Martha C Daza
Journal:  J Mol Model       Date:  2021-06-11       Impact factor: 1.810

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