Literature DB >> 12781177

Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.

Siham El Fangour1, Laurence Balas, Jean-Claude Rossi, Andrey Fedenyuk, Natalia Gretskaya, Mikhail Bobrov, Vladimir Bezuglov, Cecilia J Hillard, Thierry Durand.   

Abstract

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.

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Year:  2003        PMID: 12781177     DOI: 10.1016/s0960-894x(03)00348-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Further advances in the synthesis of endocannabinoid-related ligands.

Authors:  Anu Mahadevan; Raj K Razdan
Journal:  AAPS J       Date:  2005-10-05       Impact factor: 4.009

2.  Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters.

Authors:  Kyle M Whitten; Alexandros Makriyannis; Subramanian K Vadivel
Journal:  Tetrahedron Lett       Date:  2012-08-18       Impact factor: 2.415

Review 3.  Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown.

Authors:  Patricia H Reggio
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

  3 in total

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