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Literature DB >> 23142872

Systematic reconstruction of RNA functional motifs with high-throughput microfluidics.

Lance Martin¹, Matthias Meier, Shawn M Lyons, Rene V Sit, William F Marzluff, Stephen R Quake, Howard Y Chang.

Abstract

We present RNA-mechanically induced trapping of molecular interactions (RNA-MITOMI), a microfluidic platform that allows integrated synthesis and functional assays for programmable RNA libraries. The interaction of a comprehensive library of RNA mutants with stem-loop-binding protein precisely defined the RNA structural and sequence features that govern affinity. The functional motif reconstructed in a single experiment on our platform uncovers new binding specificities and enriches interpretation of phylogenetic data.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 23142872 PMCID： PMC3863600 DOI： 10.1038/nmeth.2225

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

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