Literature DB >> 23108075

Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.

Adam G Newman1, Anna L Vagstad, Katherine Belecki, Jonathan R Scheerer, Craig A Townsend.   

Abstract

The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.

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Year:  2012        PMID： 23108075      PMCID： PMC3505724          DOI： 10.1039/c2cc36010a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  21 in total

1.  Protein secondary structure prediction based on position-specific scoring matrices.

Authors:  D T Jones
Journal:  J Mol Biol       Date:  1999-09-17       Impact factor: 5.469

2.  The Photoactivated Cercospora Toxin Cercosporin: Contributions to Plant Disease and Fundamental Biology.

Authors:  Margaret E Daub; Marilyn Ehrenshaft
Journal:  Annu Rev Phytopathol       Date:  2000-09       Impact factor: 13.078

3.  A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

Authors:  Daniel W Udwary; Matthew Merski; Craig A Townsend
Journal:  J Mol Biol       Date:  2002-10-25       Impact factor: 5.469

4.  Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".

Authors:  Jason M Crawford; Anna L Vagstad; Karen P Whitworth; Kenneth C Ehrlich; Craig A Townsend
Journal:  Chembiochem       Date:  2008-05-05       Impact factor: 3.164

5.  Triacetic acid lactone, a derailment product of fatty acid biosynthesis.

Authors:  M Yalpani; K Willecke; F Lynen
Journal:  Eur J Biochem       Date:  1969-04

6.  Changes in tobacco cell membrane composition and structure caused by cercosporin.

Authors:  M E Daub; S P Briggs
Journal:  Plant Physiol       Date:  1983-04       Impact factor: 8.340

7.  Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.

Authors:  Anna L Vagstad; Stefanie B Bumpus; Katherine Belecki; Neil L Kelleher; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2012-04-09       Impact factor: 15.419

8.  Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.

Authors:  Antonio C Ruzzini; Subhangi Ghosh; Geoff P Horsman; Leonard J Foster; Jeffrey T Bolin; Lindsay D Eltis
Journal:  J Am Chem Soc       Date:  2012-03-05       Impact factor: 15.419

9.  The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae.

Authors:  Mathias Choquer; Katherine L Dekkers; Hui-Qin Chen; Lihua Cao; Peter P Ueng; Margaret E Daub; Kuang-Ren Chung
Journal:  Mol Plant Microbe Interact       Date:  2005-05       Impact factor: 4.171

10.  Kinetic analysis of the malonyl coenzyme A decarboxylation and the condensation reaction of fatty acid synthesis. Application to the study of malonyl coenzyme A inactivated chicken liver fatty acid synthetase.

Authors:  K R Srinivasan; S Kumar
Journal:  Biochemistry       Date:  1981-06-09       Impact factor: 3.162
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  16 in total

1.  Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.

Authors:  Aaron A Koch; Jennifer J Schmidt; Andrew N Lowell; Douglas A Hansen; Katherine M Coburn; Joseph A Chemler; David H Sherman
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2.  LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

Authors:  Wei Xu; Yit-Heng Chooi; Jin W Choi; Shuang Li; John C Vederas; Nancy A Da Silva; Yi Tang
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3.  Docking analysis of hexanoic acid and quercetin with seven domains of polyketide synthase A provided insight into quercetin-mediated aflatoxin biosynthesis inhibition in Aspergillus flavus.

Authors:  Shraddha Tiwari; Sonia K Shishodia; Jata Shankar
Journal:  3 Biotech       Date:  2019-03-25       Impact factor: 2.406

4.  Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

Authors:  Maria L Adrover-Castellano; Jennifer J Schmidt; David H Sherman
Journal:  ChemCatChem       Date:  2021-01-28       Impact factor: 5.686

5.  Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.

Authors:  Yuquan Xu; Tong Zhou; Shuwei Zhang; Li-Jiang Xuan; Jixun Zhan; István Molnár
Journal:  J Am Chem Soc       Date:  2013-07-12       Impact factor: 15.419

6.  Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

Authors:  Chen Wang; Xiaojing Wang; Liwen Zhang; Qun Yue; Qingpei Liu; Ya-Ming Xu; A A Leslie Gunatilaka; Xiaoyi Wei; Yuquan Xu; István Molnár
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

7.  Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase.

Authors:  Shu-Shan Gao; Abing Duan; Wei Xu; Peiyuan Yu; Leibniz Hang; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2016-03-22       Impact factor: 15.419

8.  Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products.

Authors:  Anna L Vagstad; Adam G Newman; Philip A Storm; Katherine Belecki; Jason M Crawford; Craig A Townsend
Journal:  Angew Chem Int Ed Engl       Date:  2013-01-02       Impact factor: 15.336

9.  Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cercospora nicotianae.

Authors:  Adam G Newman; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2016-03-16       Impact factor: 15.419

10.  The structural organization of substrate loading in iterative polyketide synthases.

Authors:  Dominik A Herbst; Callie R Huitt-Roehl; Roman P Jakob; Jacob M Kravetz; Philip A Storm; Jamie R Alley; Craig A Townsend; Timm Maier
Journal:  Nat Chem Biol       Date:  2018-04-02       Impact factor: 15.040
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