Literature DB >> 23080337

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.

Eva van Rooij1, Eric N Olson.   

Abstract

In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.

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Year:  2012        PMID： 23080337      PMCID： PMC6813819          DOI： 10.1038/nrd3864

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  107 in total

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2.  Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

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3.  Transient regenerative potential of the neonatal mouse heart.

Authors:  Enzo R Porrello; Ahmed I Mahmoud; Emma Simpson; Joseph A Hill; James A Richardson; Eric N Olson; Hesham A Sadek
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4.  Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure.

Authors:  Rusty L Montgomery; Thomas G Hullinger; Hillary M Semus; Brent A Dickinson; Anita G Seto; Joshua M Lynch; Christianna Stack; Paul A Latimer; Eric N Olson; Eva van Rooij
Journal:  Circulation       Date:  2011-09-06       Impact factor: 29.690

5.  miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes.

Authors:  Li Qian; Linda W Van Laake; Yu Huang; Siyuan Liu; Michael F Wendland; Deepak Srivastava
Journal:  J Exp Med       Date:  2011-03-07       Impact factor: 14.307

6.  MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation.

Authors:  Ulf Andersson Ørom; Finn Cilius Nielsen; Anders H Lund
Journal:  Mol Cell       Date:  2008-05-23       Impact factor: 17.970

7.  Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

Authors:  Carmela Zincarelli; Stephen Soltys; Giuseppe Rengo; Joseph E Rabinowitz
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8.  Mediator MED23 links insulin signaling to the adipogenesis transcription cascade.

Authors:  Wei Wang; Lu Huang; Yan Huang; Jing-wen Yin; Arnold J Berk; Jeffrey M Friedman; Gang Wang
Journal:  Dev Cell       Date:  2009-05       Impact factor: 12.270

9.  Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.

Authors:  Janaiah Kota; Raghu R Chivukula; Kathryn A O'Donnell; Erik A Wentzel; Chrystal L Montgomery; Hun-Way Hwang; Tsung-Cheng Chang; Perumal Vivekanandan; Michael Torbenson; K Reed Clark; Jerry R Mendell; Joshua T Mendell
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

10.  A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

Authors:  Eva van Rooij; Daniel Quiat; Brett A Johnson; Lillian B Sutherland; Xiaoxia Qi; James A Richardson; Robert J Kelm; Eric N Olson
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  254 in total

1.  MicroRNA-21 inhibits platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration through targeting activator protein-1.

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Review 2.  Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

Authors:  Maria Moccia; Mauro F A Adamo; Michele Saviano
Journal:  Artif DNA PNA XNA       Date:  2016-01-11

Review 3.  The non-coding road towards cardiac regeneration.

Authors:  James E Hudson; Enzo R Porrello
Journal:  J Cardiovasc Transl Res       Date:  2013-12       Impact factor: 4.132

Review 4.  Image-guided therapies for myocardial repair: concepts and practical implementation.

Authors:  Frank M Bengel; Richard T George; Karl H Schuleri; Albert C Lardo; Kai C Wollert
Journal:  Eur Heart J Cardiovasc Imaging       Date:  2013-05-29       Impact factor: 6.875

Review 5.  Managing microRNAs with vector-encoded decoy-type inhibitors.

Authors:  Rasmus O Bak; Anne Kruse Hollensen; Jacob Giehm Mikkelsen
Journal:  Mol Ther       Date:  2013-06-11       Impact factor: 11.454

Review 6.  MicroRNAs and other non-coding RNAs as targets for anticancer drug development.

Authors:  Hui Ling; Muller Fabbri; George A Calin
Journal:  Nat Rev Drug Discov       Date:  2013-11       Impact factor: 84.694

7.  MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma.

Authors:  Chenggang Wang; Ren Ren; Haolin Hu; Changjun Tan; Miao Han; Xiaolin Wang; Yun Zheng
Journal:  Chin J Cancer Res       Date:  2014-02       Impact factor: 5.087

8.  Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.

Authors:  Denuja Karunakaran; A Brianne Thrush; My-Anh Nguyen; Laura Richards; Michele Geoffrion; Ragunath Singaravelu; Eleni Ramphos; Prakriti Shangari; Mireille Ouimet; John P Pezacki; Kathryn J Moore; Ljubica Perisic; Lars Maegdefessel; Ulf Hedin; Mary-Ellen Harper; Katey J Rayner
Journal:  Circ Res       Date:  2015-05-22       Impact factor: 17.367

9.  Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.

Authors:  Chan Woo Kim; Sandeep Kumar; Dong Ju Son; In-Hwan Jang; Kathy K Griendling; Hanjoong Jo
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-05-08       Impact factor: 8.311

10.  Circulating Plasma Extracellular Vesicles from Septic Mice Induce Inflammation via MicroRNA- and TLR7-Dependent Mechanisms.

Authors:  Jinjin Xu; Yan Feng; Anjana Jeyaram; Steven M Jay; Lin Zou; Wei Chao
Journal:  J Immunol       Date:  2018-10-24       Impact factor: 5.422
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