Literature DB >> 26752710

Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

Maria Moccia1, Mauro F A Adamo2, Michele Saviano1.   

Abstract

PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed.

Keywords:  PNA; antisense; backbone modification; chirality; miRNA

Mesh：

Substances：

Year:  2016        PMID： 26752710      PMCID： PMC5329900          DOI： 10.1080/1949095X.2015.1107176

Source DB:  PubMed          Journal:  Artif DNA PNA XNA        ISSN： 1949-095X


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