Literature DB >> 23065610

The chemical identification and analysis of Aspergillus nidulans secondary metabolites.

James F Sanchez1, Clay C C Wang.   

Abstract

Filamentous fungi have long been recognized to be a rich source of secondary metabolites with potential medicinal applications. The recent genomic sequencing of several Aspergillus species has revealed that many secondary metabolite gene clusters are apparently silent under standard laboratory conditions. Several successful approaches have been utilized to upregulate these genes and unearth the corresponding natural products. A straightforward, reliable method to purify and characterize new metabolites therefore should be useful. Details are provided herein on the cultivation of Aspergillus nidulans and the LC/MS analysis of the metabolic profile. Following is an explanation of silica gel chromatography, HPLC, and preparative TLC. Finally, the NMR characterization of previously unknown A. nidulans metabolites is detailed.

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Year:  2012        PMID： 23065610      PMCID： PMC3754429          DOI： 10.1007/978-1-62703-122-6_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

Authors:  J Kennedy; K Auclair; S G Kendrew; C Park; J C Vederas; C R Hutchinson
Journal:  Science       Date:  1999-05-21       Impact factor: 47.728

2.  Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.

Authors:  James F Sanchez; Yi-Ming Chiang; Edyta Szewczyk; Ashley D Davidson; Manmeet Ahuja; C Elizabeth Oakley; Jin Woo Bok; Nancy Keller; Berl R Oakley; Clay C C Wang
Journal:  Mol Biosyst       Date:  2009-12-16

3.  Chromatin-level regulation of biosynthetic gene clusters.

Authors:  Jin Woo Bok; Yi-Ming Chiang; Edyta Szewczyk; Yazmid Reyes-Dominguez; Ashley D Davidson; James F Sanchez; Hsien-Chun Lo; Kenji Watanabe; Joseph Strauss; Berl R Oakley; Clay C C Wang; Nancy P Keller
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

4.  Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus.

Authors:  G A Payne; G J Nystrom; D Bhatnagar; T E Cleveland; C P Woloshuk
Journal:  Appl Environ Microbiol       Date:  1993-01       Impact factor: 4.792

5.  Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans.

Authors:  Edyta Szewczyk; Yi-Ming Chiang; C Elizabeth Oakley; Ashley D Davidson; Clay C C Wang; Berl R Oakley
Journal:  Appl Environ Microbiol       Date:  2008-10-31       Impact factor: 4.792

6.  A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans.

Authors:  Yi-Ming Chiang; Edyta Szewczyk; Ashley D Davidson; Nancy Keller; Berl R Oakley; Clay C C Wang
Journal:  J Am Chem Soc       Date:  2009-03-04       Impact factor: 15.419

7.  Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88.

Authors:  Herman J Pel; Johannes H de Winde; David B Archer; Paul S Dyer; Gerald Hofmann; Peter J Schaap; Geoffrey Turner; Ronald P de Vries; Richard Albang; Kaj Albermann; Mikael R Andersen; Jannick D Bendtsen; Jacques A E Benen; Marco van den Berg; Stefaan Breestraat; Mark X Caddick; Roland Contreras; Michael Cornell; Pedro M Coutinho; Etienne G J Danchin; Alfons J M Debets; Peter Dekker; Piet W M van Dijck; Alard van Dijk; Lubbert Dijkhuizen; Arnold J M Driessen; Christophe d'Enfert; Steven Geysens; Coenie Goosen; Gert S P Groot; Piet W J de Groot; Thomas Guillemette; Bernard Henrissat; Marga Herweijer; Johannes P T W van den Hombergh; Cees A M J J van den Hondel; Rene T J M van der Heijden; Rachel M van der Kaaij; Frans M Klis; Harrie J Kools; Christian P Kubicek; Patricia A van Kuyk; Jürgen Lauber; Xin Lu; Marc J E C van der Maarel; Rogier Meulenberg; Hildegard Menke; Martin A Mortimer; Jens Nielsen; Stephen G Oliver; Maurien Olsthoorn; Karoly Pal; Noël N M E van Peij; Arthur F J Ram; Ursula Rinas; Johannes A Roubos; Cees M J Sagt; Monika Schmoll; Jibin Sun; David Ussery; Janos Varga; Wouter Vervecken; Peter J J van de Vondervoort; Holger Wedler; Han A B Wösten; An-Ping Zeng; Albert J J van Ooyen; Jaap Visser; Hein Stam
Journal:  Nat Biotechnol       Date:  2007-01-28       Impact factor: 54.908

8.  Genome sequencing and analysis of Aspergillus oryzae.

Authors:  Masayuki Machida; Kiyoshi Asai; Motoaki Sano; Toshihiro Tanaka; Toshitaka Kumagai; Goro Terai; Ken-Ichi Kusumoto; Toshihide Arima; Osamu Akita; Yutaka Kashiwagi; Keietsu Abe; Katsuya Gomi; Hiroyuki Horiuchi; Katsuhiko Kitamoto; Tetsuo Kobayashi; Michio Takeuchi; David W Denning; James E Galagan; William C Nierman; Jiujiang Yu; David B Archer; Joan W Bennett; Deepak Bhatnagar; Thomas E Cleveland; Natalie D Fedorova; Osamu Gotoh; Hiroshi Horikawa; Akira Hosoyama; Masayuki Ichinomiya; Rie Igarashi; Kazuhiro Iwashita; Praveen Rao Juvvadi; Masashi Kato; Yumiko Kato; Taishin Kin; Akira Kokubun; Hiroshi Maeda; Noriko Maeyama; Jun-ichi Maruyama; Hideki Nagasaki; Tasuku Nakajima; Ken Oda; Kinya Okada; Ian Paulsen; Kazutoshi Sakamoto; Toshihiko Sawano; Mikio Takahashi; Kumiko Takase; Yasunobu Terabayashi; Jennifer R Wortman; Osamu Yamada; Youhei Yamagata; Hideharu Anazawa; Yoji Hata; Yoshinao Koide; Takashi Komori; Yasuji Koyama; Toshitaka Minetoki; Sivasundaram Suharnan; Akimitsu Tanaka; Katsumi Isono; Satoru Kuhara; Naotake Ogasawara; Hisashi Kikuchi
Journal:  Nature       Date:  2005-12-22       Impact factor: 49.962

9.  Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.

Authors:  William C Nierman; Arnab Pain; Michael J Anderson; Jennifer R Wortman; H Stanley Kim; Javier Arroyo; Matthew Berriman; Keietsu Abe; David B Archer; Clara Bermejo; Joan Bennett; Paul Bowyer; Dan Chen; Matthew Collins; Richard Coulsen; Robert Davies; Paul S Dyer; Mark Farman; Nadia Fedorova; Natalie Fedorova; Tamara V Feldblyum; Reinhard Fischer; Nigel Fosker; Audrey Fraser; Jose L García; Maria J García; Arlette Goble; Gustavo H Goldman; Katsuya Gomi; Sam Griffith-Jones; Ryan Gwilliam; Brian Haas; Hubertus Haas; David Harris; H Horiuchi; Jiaqi Huang; Sean Humphray; Javier Jiménez; Nancy Keller; Hoda Khouri; Katsuhiko Kitamoto; Tetsuo Kobayashi; Sven Konzack; Resham Kulkarni; Toshitaka Kumagai; Anne Lafon; Anne Lafton; Jean-Paul Latgé; Weixi Li; Angela Lord; Charles Lu; William H Majoros; Gregory S May; Bruce L Miller; Yasmin Mohamoud; Maria Molina; Michel Monod; Isabelle Mouyna; Stephanie Mulligan; Lee Murphy; Susan O'Neil; Ian Paulsen; Miguel A Peñalva; Mihaela Pertea; Claire Price; Bethan L Pritchard; Michael A Quail; Ester Rabbinowitsch; Neil Rawlins; Marie-Adele Rajandream; Utz Reichard; Hubert Renauld; Geoffrey D Robson; Santiago Rodriguez de Córdoba; Jose M Rodríguez-Peña; Catherine M Ronning; Simon Rutter; Steven L Salzberg; Miguel Sanchez; Juan C Sánchez-Ferrero; David Saunders; Kathy Seeger; Rob Squares; Steven Squares; Michio Takeuchi; Fredj Tekaia; Geoffrey Turner; Carlos R Vazquez de Aldana; Janice Weidman; Owen White; John Woodward; Jae-Hyuk Yu; Claire Fraser; James E Galagan; Kiyoshi Asai; Masayuki Machida; Neil Hall; Bart Barrell; David W Denning
Journal:  Nature       Date:  2005-12-22       Impact factor: 49.962

10.  Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Authors:  James E Galagan; Sarah E Calvo; Christina Cuomo; Li-Jun Ma; Jennifer R Wortman; Serafim Batzoglou; Su-In Lee; Meray Baştürkmen; Christina C Spevak; John Clutterbuck; Vladimir Kapitonov; Jerzy Jurka; Claudio Scazzocchio; Mark Farman; Jonathan Butler; Seth Purcell; Steve Harris; Gerhard H Braus; Oliver Draht; Silke Busch; Christophe D'Enfert; Christiane Bouchier; Gustavo H Goldman; Deborah Bell-Pedersen; Sam Griffiths-Jones; John H Doonan; Jaehyuk Yu; Kay Vienken; Arnab Pain; Michael Freitag; Eric U Selker; David B Archer; Miguel A Peñalva; Berl R Oakley; Michelle Momany; Toshihiro Tanaka; Toshitaka Kumagai; Kiyoshi Asai; Masayuki Machida; William C Nierman; David W Denning; Mark Caddick; Michael Hynes; Mathieu Paoletti; Reinhard Fischer; Bruce Miller; Paul Dyer; Matthew S Sachs; Stephen A Osmani; Bruce W Birren
Journal:  Nature       Date:  2005-12-22       Impact factor: 49.962
  10 in total
  4 in total

1.  Rice-induced secondary metabolite gene expression in Aspergillus nidulans.

Authors:  Christopher J Lacriola; Shaun P Falk; Bernard Weisblum
Journal:  J Ind Microbiol Biotechnol       Date:  2020-11-18       Impact factor: 3.346

2.  Transcriptional Control of the Production of Aspergillus fumigatus Conidia-Borne Secondary Metabolite Fumiquinazoline C Important for Phagocytosis Protection.

Authors:  Marina Campos Rocha; João Henrique Tadini Marilhano Fabri; Lilian Pereira Silva; Célio Fernando Figueiredo Angolini; Maria Célia Bertolini; Anderson Ferreira da Cunha; Vito Valiante; Gustavo Henrique Goldman; Taicia Pacheco Fill; Iran Malavazi
Journal:  Genetics       Date:  2021-05-17       Impact factor: 4.402

3.  Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks.

Authors:  P Schäpe; M J Kwon; B Baumann; B Gutschmann; S Jung; S Lenz; B Nitsche; N Paege; T Schütze; T C Cairns; V Meyer
Journal:  Nucleic Acids Res       Date:  2019-01-25       Impact factor: 16.971

Review 4.  Systems Biology Approaches for Host-Fungal Interactions: An Expanding Multi-Omics Frontier.

Authors:  Luka Culibrk; Carys A Croft; Scott J Tebbutt
Journal:  OMICS       Date:  2016-02-17
  4 in total

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