| Literature DB >> 17259976 |
Herman J Pel1, Johannes H de Winde, David B Archer, Paul S Dyer, Gerald Hofmann, Peter J Schaap, Geoffrey Turner, Ronald P de Vries, Richard Albang, Kaj Albermann, Mikael R Andersen, Jannick D Bendtsen, Jacques A E Benen, Marco van den Berg, Stefaan Breestraat, Mark X Caddick, Roland Contreras, Michael Cornell, Pedro M Coutinho, Etienne G J Danchin, Alfons J M Debets, Peter Dekker, Piet W M van Dijck, Alard van Dijk, Lubbert Dijkhuizen, Arnold J M Driessen, Christophe d'Enfert, Steven Geysens, Coenie Goosen, Gert S P Groot, Piet W J de Groot, Thomas Guillemette, Bernard Henrissat, Marga Herweijer, Johannes P T W van den Hombergh, Cees A M J J van den Hondel, Rene T J M van der Heijden, Rachel M van der Kaaij, Frans M Klis, Harrie J Kools, Christian P Kubicek, Patricia A van Kuyk, Jürgen Lauber, Xin Lu, Marc J E C van der Maarel, Rogier Meulenberg, Hildegard Menke, Martin A Mortimer, Jens Nielsen, Stephen G Oliver, Maurien Olsthoorn, Karoly Pal, Noël N M E van Peij, Arthur F J Ram, Ursula Rinas, Johannes A Roubos, Cees M J Sagt, Monika Schmoll, Jibin Sun, David Ussery, Janos Varga, Wouter Vervecken, Peter J J van de Vondervoort, Holger Wedler, Han A B Wösten, An-Ping Zeng, Albert J J van Ooyen, Jaap Visser, Hein Stam.
Abstract
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.Entities:
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Year: 2007 PMID： 17259976 DOI： 10.1038/nbt1282
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908