BACKGROUND/AIMS: The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obese children with and without metabolic syndrome (MetS). METHODS: We recruited 25 Caucasian obese children with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. RESULTS: d-ROM level was significantly higher in obese children with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). CONCLUSIONS: This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age.
BACKGROUND/AIMS: The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obesechildren with and without metabolic syndrome (MetS). METHODS: We recruited 25 Caucasian obesechildren with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. RESULTS: d-ROM level was significantly higher in obesechildren with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). CONCLUSIONS: This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age.
Authors: George Paltoglou; Ioannis G Fatouros; George Valsamakis; Maria Schoina; Alexandra Avloniti; Athanasios Chatzinikolaou; Antonis Kambas; Dimitris Draganidis; Aimilia Mantzou; Maria Papagianni; Christina Kanaka-Gantenbein; George P Chrousos; George Mastorakos Journal: Pediatr Res Date: 2015-05-04 Impact factor: 3.756
Authors: María G Soto-Urquieta; Sergio López-Briones; Victoriano Pérez-Vázquez; Alfredo Saavedra-Molina; Gloria A González-Hernández; Joel Ramírez-Emiliano Journal: Biol Res Date: 2014-12-22 Impact factor: 5.612
Authors: Salem S Al-Rejaie; Abdulaziz M Aleisa; Mohamed M Sayed-Ahmed; Othman A Al-Shabanah; Hatem M Abuohashish; Mohammed M Ahmed; Khaled A Al-Hosaini; Mohamed M Hafez Journal: BMC Complement Altern Med Date: 2013-06-17 Impact factor: 3.659