George Paltoglou1, Ioannis G Fatouros2, George Valsamakis3, Maria Schoina2, Alexandra Avloniti2, Athanasios Chatzinikolaou2, Antonis Kambas2, Dimitris Draganidis2, Aimilia Mantzou4, Maria Papagianni5, Christina Kanaka-Gantenbein3, George P Chrousos3, George Mastorakos6. 1. 1] Endocrine Unit, Aretaieion Hospital, University of Athens Medical School, Athens, Greece [2] First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens Medical School, Athens, Greece. 2. School of Physical Education and Sports Sciences, Democritus University of Thrace, Komotini, Greece. 3. First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens Medical School, Athens, Greece. 4. Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, Athens, Greece. 5. Pediatric Endocrinology Unit, Third Department of Pediatrics, Hippokrateion General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece. 6. Endocrine Unit, Aretaieion Hospital, University of Athens Medical School, Athens, Greece.
Abstract
BACKGROUND: Oxidative stress is associated with obesity while the evidence for the role of GH in pro- and antioxidation is inconclusive. This study investigates the relationships between growth hormone (GH), pro- and antioxidation in relation to obesity and puberty before and after an acute bout of exercise. METHODS: In this case-control study, 76 healthy normal-weight and obese, prepubertal and pubertal boys underwent a blood sampling before and immediately after an aerobic exercise bout until exhaustion at 70% maximal oxygen consumption. Markers of prooxidation (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs)) and antioxidation (glutathione (GSH), oxidized glutathione disulfide (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPX), catalase, and total antioxidant capacity (TAC)) and hormones (GH, insulin-like growth factor (IGF)-1, IGF-BP-3, luteinizing hormone, follicle-stimulating hormone, and testosterone) were measured. RESULTS: Baseline and postexercise TBARS and PCs were greater, while baseline GSH, GSH/GSSG ratio, GPX, and TAC were lower in obese than that in normal-weight participants. In all participants, waist was the best negative and positive predictor for postexercise GPX and TBARS, respectively. Baseline TAC was greater in pubertal than that in pre-pubertal participants. In all participants, baseline GH was the best negative predictor for postexercise PCs. Significant positive linear correlation exists between the exercise-associated GH, and GSSG increases in pubertal normal-weight boys. CONCLUSIONS: Higher prooxidation and lower antioxidation were observed in obese boys, while antioxidation improves with puberty and postexercise, paralleling GH accentuated secretion.
BACKGROUND: Oxidative stress is associated with obesity while the evidence for the role of GH in pro- and antioxidation is inconclusive. This study investigates the relationships between growth hormone (GH), pro- and antioxidation in relation to obesity and puberty before and after an acute bout of exercise. METHODS: In this case-control study, 76 healthy normal-weight and obese, prepubertal and pubertal boys underwent a blood sampling before and immediately after an aerobic exercise bout until exhaustion at 70% maximal oxygen consumption. Markers of prooxidation (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs)) and antioxidation (glutathione (GSH), oxidized glutathione disulfide (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPX), catalase, and total antioxidant capacity (TAC)) and hormones (GH, insulin-like growth factor (IGF)-1, IGF-BP-3, luteinizing hormone, follicle-stimulating hormone, and testosterone) were measured. RESULTS: Baseline and postexercise TBARS and PCs were greater, while baseline GSH, GSH/GSSG ratio, GPX, and TAC were lower in obese than that in normal-weight participants. In all participants, waist was the best negative and positive predictor for postexercise GPX and TBARS, respectively. Baseline TAC was greater in pubertal than that in pre-pubertal participants. In all participants, baseline GH was the best negative predictor for postexercise PCs. Significant positive linear correlation exists between the exercise-associated GH, and GSSG increases in pubertal normal-weight boys. CONCLUSIONS: Higher prooxidation and lower antioxidation were observed in obeseboys, while antioxidation improves with puberty and postexercise, paralleling GH accentuated secretion.
Authors: E Cholez; V Debuysscher; J Bourgeais; C Boudot; J Leprince; F Tron; B Brassart; A Regnier; E Bissac; E Pecnard; F Gouilleux; K Lassoued; V Gouilleux-Gruart Journal: Leukemia Date: 2012-04-23 Impact factor: 11.528
Authors: George Paltoglou; Maria Schoina; George Valsamakis; Nicolaos Salakos; Alexandra Avloniti; Athanasios Chatzinikolaou; Alexandra Margeli; Chrysanthi Skevaki; Maria Papagianni; Christina Kanaka-Gantenbein; Ioannis Papassotiriou; George P Chrousos; Ioannis G Fatouros; George Mastorakos Journal: Endocrine Date: 2017-01-16 Impact factor: 3.633
Authors: George Paltoglou; Alexandra Avloniti; Athanasios Chatzinikolaou; Charikleia Stefanaki; Maria Papagianni; Ioannis Papassotiriou; Ioannis G Fatouros; George P Chrousos; Christina Kanaka-Gantenbein; George Mastorakos Journal: Endocrine Date: 2019-08-04 Impact factor: 3.633
Authors: Alexandra Avloniti; Athanasios Chatzinikolaou; Chariklia K Deli; Dimitris Vlachopoulos; Luis Gracia-Marco; Diamanda Leontsini; Dimitrios Draganidis; Athanasios Z Jamurtas; George Mastorakos; Ioannis G Fatouros Journal: Antioxidants (Basel) Date: 2017-01-17
Authors: Charikleia Stefanaki; Athanasios Michos; George Latsios; Dimitrios Tousoulis; Melpomeni Peppa; Paraskevi Zosi; Dario Boschiero; Flora Bacopoulou Journal: Int J Environ Res Public Health Date: 2020-04-14 Impact factor: 3.390