Literature DB >> 23042574

Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.

Katherine Belecki1, Craig A Townsend.   

Abstract

A light in the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioesterase) were identified and gave some insight into the elusive early steps of calicheamicin biosynthesis. Fermentation in either the light or dark resulted in different proportions of a new octaketide and led to an updated mechanistic proposal.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23042574      PMCID： PMC3487408          DOI： 10.1002/anie.201206462

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  16 in total

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3.  A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.

Authors:  Jian Zhang; Steven G Van Lanen; Jianhua Ju; Wen Liu; Pieter C Dorrestein; Wenli Li; Neil L Kelleher; Ben Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-25       Impact factor: 11.205

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5.  Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.

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Authors:  Ronald L Christensen; Elizabeth A Barney; Richard D Broene; Mary Grace I Galinato; Harry A Frank
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7.  Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis.

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Journal:  J Am Chem Soc       Date:  2008-06-05       Impact factor: 15.419

8.  Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

Authors:  Steven G Van Lanen; Tae-Jin Oh; Wen Liu; Evelyn Wendt-Pienkowski; Ben Shen
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9.  Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures.

Authors:  Katherine Belecki; Jason M Crawford; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

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Authors:  Qunjie Gao; Jon S Thorson
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2.  Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.

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Journal:  Angew Chem Int Ed Engl       Date:  2018-03-24       Impact factor: 15.336

3.  Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.

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Journal:  J Am Chem Soc       Date:  2013-09-17       Impact factor: 15.419

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Review 5.  Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.

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Journal:  Appl Microbiol Biotechnol       Date:  2015-11-09       Impact factor: 4.813

6.  Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.

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Journal:  J Antibiot (Tokyo)       Date:  2016-07-13       Impact factor: 2.649

7.  A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis.

Authors:  Douglas R Cohen; Craig A Townsend
Journal:  Nat Chem       Date:  2017-11-20       Impact factor: 24.427

8.  Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19.

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Journal:  ACS Chem Biol       Date:  2014-08-13       Impact factor: 5.100
  8 in total

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