Literature DB >> 18529057

Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis.

Rong Kong1, Lan Pei Goh, Chong Wai Liew, Qin Shi Ho, Elavazhagan Murugan, Bin Li, Kai Tang, Zhao-Xun Liang.   

Abstract

We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the 10-membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of enediyne biosynthesis starts at the PKS stage.

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Year:  2008        PMID： 18529057     DOI： 10.1021/ja8019643

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  15 in total

1.  Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.

Authors:  Geoff P Horsman; Yihua Chen; Jon S Thorson; Ben Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

2.  Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

Authors:  Jeffrey D Rudolf; Xiaohui Yan; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2015-08-29       Impact factor: 3.346

3.  Rigidifying acyl carrier protein domain in iterative type I PKS CalE8 does not affect its function.

Authors:  Jackwee Lim; Huihua Sun; Jing-Song Fan; Iman Fahim Hameed; Julien Lescar; Zhao-Xun Liang; Daiwen Yang
Journal:  Biophys J       Date:  2012-09-05       Impact factor: 4.033

4.  Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.

Authors:  Douglas R Cohen; Craig A Townsend
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-24       Impact factor: 15.336

5.  Natural products version 2.0: connecting genes to molecules.

Authors:  Christopher T Walsh; Michael A Fischbach
Journal:  J Am Chem Soc       Date:  2010-03-03       Impact factor: 15.419

6.  Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2013-09-17       Impact factor: 15.419

7.  Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis.

Authors:  Masayo Kotaka; Rong Kong; Insaf Qureshi; Qin Shi Ho; Huihua Sun; Chong Wai Liew; Lan Pei Goh; Peter Cheung; Yuguang Mu; Julien Lescar; Zhao-Xun Liang
Journal:  J Biol Chem       Date:  2009-04-08       Impact factor: 5.157

8.  Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-08       Impact factor: 15.336

9.  Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures.

Authors:  Katherine Belecki; Jason M Crawford; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

10.  Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.

Authors:  Chong Wai Liew; Martina Nilsson; Ming Wei Chen; Huihua Sun; Tobias Cornvik; Zhao-Xun Liang; Julien Lescar
Journal:  J Biol Chem       Date:  2012-05-15       Impact factor: 5.157
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