Literature DB >> 23040829

Finite element static displacement optimization of 20-100 kHz flexural transducers for fully portable ultrasound applicator.

Christopher R Bawiec1, Youhan Sunny, An T Nguyen, Joshua A Samuels, Michael S Weingarten, Leonid A Zubkov, Peter A Lewin.   

Abstract

This paper focuses on the development of a finite-element model and subsequent stationary analysis performed to optimize individual flexural piezoelectric elements for operation in the frequency range of 20-100kHz. These elements form the basic building blocks of a viable, un-tethered, and portable ultrasound applicator that can produce intensities on the order of 100mW/cm(2) spatial-peak temporal-peak (I(SPTP)) with minimum (on the order of 15V) excitation voltage. The ultrasound applicator can be constructed with different numbers of individual transducer elements and different geometries such that its footprint or active area is adjustable. The primary motivation behind this research was to develop a tether-free, battery operated, fully portable ultrasound applicator for therapeutic applications such as wound healing and non-invasive transdermal delivery of both naked and encapsulated drugs. It is shown that careful selection of the components determining applicator architecture allows the displacement amplitude to be maximized for a specific frequency of operation. The work described here used the finite-element analysis software COMSOL to identify the geometry and material properties that permit the applicator's design to be optimized. By minimizing the excitation voltage required to achieve the desired output (100mW/cm(2)I(SPTP)) the power source (rechargeable Li-Polymer batteries) size may be reduced permitting both the electronics and ultrasound applicator to fit in a wearable housing.
Copyright © 2012. Published by Elsevier B.V.

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Year:  2012        PMID: 23040829      PMCID: PMC3568635          DOI: 10.1016/j.ultras.2012.09.005

Source DB:  PubMed          Journal:  Ultrasonics        ISSN: 0041-624X            Impact factor:   2.890


  16 in total

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Authors:  Ahmet Tezel; Samir Mitragotri
Journal:  Biophys J       Date:  2003-12       Impact factor: 4.033

2.  Current status of the use of modalities in wound care: electrical stimulation and ultrasound therapy.

Authors:  William J Ennis; Claudia Lee; Malgorzata Plummer; Patricio Meneses
Journal:  Plast Reconstr Surg       Date:  2011-01       Impact factor: 4.730

3.  Bubble growth within the skin by rectified diffusion might play a significant role in sonophoresis.

Authors:  Ilana Lavon; Nili Grossman; Joseph Kost; Eitan Kimmel; Giora Enden
Journal:  J Control Release       Date:  2006-11-06       Impact factor: 9.776

4.  Fabrication and evaluation of a single-element Bi0.5Na0.5TiO3-based ultrasonic transducer.

Authors:  M Mehdi Hejazi; Bahram Jadidian; Ahmad Safari
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2012-08       Impact factor: 2.725

Review 5.  Low-frequency sonophoresis: current status and future prospects.

Authors:  Makoto Ogura; Sumit Paliwal; Samir Mitragotri
Journal:  Adv Drug Deliv Rev       Date:  2008-04-03       Impact factor: 15.470

Review 6.  Liposomes in ultrasonic drug and gene delivery.

Authors:  Shao-Ling Huang
Journal:  Adv Drug Deliv Rev       Date:  2008-04-03       Impact factor: 15.470

7.  Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects.

Authors:  Boris Krasovitski; Victor Frenkel; Shy Shoham; Eitan Kimmel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-07       Impact factor: 11.205

Review 8.  Overview of therapeutic ultrasound applications and safety considerations.

Authors:  Douglas L Miller; Nadine B Smith; Michael R Bailey; Gregory J Czarnota; Kullervo Hynynen; Inder Raj S Makin
Journal:  J Ultrasound Med       Date:  2012-04       Impact factor: 2.153

9.  Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy.

Authors:  Ahmet Tezel; Ashley Sens; Samir Mitragotri
Journal:  J Pharm Sci       Date:  2002-02       Impact factor: 3.534

10.  Ultrasound mediated transdermal insulin delivery in pigs using a lightweight transducer.

Authors:  E J Park; Jacob Werner; Nadine Barrie Smith
Journal:  Pharm Res       Date:  2007-04-19       Impact factor: 4.580

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  8 in total

1.  Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs.

Authors:  Carl M Schoellhammer; Sharanya Srinivasan; Ross Barman; Stacy H Mo; Baris E Polat; Robert Langer; Daniel Blankschtein
Journal:  J Control Release       Date:  2015-02-04       Impact factor: 9.776

Review 2.  Skin permeabilization for transdermal drug delivery: recent advances and future prospects.

Authors:  Carl M Schoellhammer; Daniel Blankschtein; Robert Langer
Journal:  Expert Opin Drug Deliv       Date:  2014-01-07       Impact factor: 6.648

Review 3.  Of microneedles and ultrasound: Physical modes of gastrointestinal macromolecule delivery.

Authors:  Carl M Schoellhammer; Robert Langer; Giovanni Traverso
Journal:  Tissue Barriers       Date:  2016-02-11

Review 4.  Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures.

Authors:  Ali Aghazadeh-Habashi; Yang Yang; Kathy Tang; Raimar Lőbenberg; Michael R Doschak
Journal:  Drug Deliv Transl Res       Date:  2015-12       Impact factor: 4.617

Review 5.  Ultrasound-enhanced transdermal delivery: recent advances and future challenges.

Authors:  Matthias A Oberli; Carl M Schoellhammer; Robert Langer; Daniel Blankschtein
Journal:  Ther Deliv       Date:  2014-07

6.  Ultrasound-mediated gastrointestinal drug delivery.

Authors:  Carl M Schoellhammer; Avi Schroeder; Ruby Maa; Gregory Yves Lauwers; Albert Swiston; Michael Zervas; Ross Barman; Angela M DiCiccio; William R Brugge; Daniel G Anderson; Daniel Blankschtein; Robert Langer; Giovanni Traverso
Journal:  Sci Transl Med       Date:  2015-10-21       Impact factor: 17.956

7.  Particle Swarm Optimization Algorithm-Based Design Method for Ultrasonic Transducers.

Authors:  Dongdong Chen; Jianxin Zhao; Chunlong Fei; Di Li; Yuanbo Zhu; Zhaoxi Li; Rong Guo; Lifei Lou; Wei Feng; Yintang Yang
Journal:  Micromachines (Basel)       Date:  2020-07-23       Impact factor: 2.891

8.  On the Shaping of a Short Signal at the Output of the Receiving Piezoelectric Transducer in the Radiation-Reception System.

Authors:  Boris Ee; Roman Konovalov; Sergey Konovalov; Andrey Kuz'menko; Valery Tsaplev
Journal:  Materials (Basel)       Date:  2018-06-08       Impact factor: 3.623

  8 in total

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